Development of a new simple spectroscopic determination coupled acid-motivated delivery system based on fluorescence turn-off MSNs@MPA-ZnS QDs for infection

Mandani, Sudabe; Rezaei, Behzad; Ensafi, Ali A.; Rahimmalek, Mehdi

doi:10.1016/j.micromeso.2021.110971

Cited by 11 publications

(11 citation statements)

References 37 publications

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“…An EDC/NHS chemistry was selected to complete the modification, which is a mild method for surface modification under room temperature [ 44 ]. Usually, EDC/NHS chemistry is employed for protein combination through carboxyl–amidogen bonding [ 44 ]. In this work.…”

Section: Methodsmentioning

confidence: 99%

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Primary Amine Functionalized Carbon Dots for Dead and Alive Bacterial Imaging

et al. 2023

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Small molecular dyes are commonly used for bacterial imaging, but they still meet a bottleneck of biological toxicity and fluorescence photobleaching. Carbon dots have shown high potential for bio-imaging due to their low cost and negligible toxicity and anti-photobleaching. However, there is still large space to enhance the quantum yield of the carbon quantum dots and to clarify their mechanisms of bacterial imaging. Using carbon dots for dyeing alive bacteria is difficult because of the thick density and complicated structure of bacterial cell walls. In this work, both dead or alive bacterial cell imaging can be achieved using the primary amine functionalized carbon dots based on their small size, excellent quantum yield and primary amine functional groups. Four types of carbon quantum dots were prepared and estimated for the bacterial imaging. It was found that the spermine as one of precursors can obviously enhance the quantum yield of carbon dots, which showed a high quantum yield of 66.46% and high fluorescence bleaching-resistance (70% can be maintained upon 3-h-irradiation). Furthermore, a mild modifying method was employed to bound ethylenediamine on the surface of the spermine–carbon dots, which is favorable for staining not only the dead bacterial cells but also the alive ones. Investigations of physical structure and chemical groups indicated the existence of primary amine groups on the surface of spermine–carbon quantum dots (which own a much higher quantum yield) which can stain alive bacterial cells visibly. The imaging mechanism was studied in detail, which provides a preliminary reference for exploring efficient and environment-friendly carbon dots for bacterial imaging.

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Section: Methodsmentioning

confidence: 99%

“…Then, 1 mL ethylenediamine was added. Subsequently, pH value was adjusted to around 10.6 [ 44 ]. After incubation for 2 h under 37 °C, the solution was dialyzed to reach the modified CD (we named them NH 2 –CD) or the modified spCD (we named them NH 2 –spCD) suspension.…”

Section: Methodsmentioning

confidence: 99%

Primary Amine Functionalized Carbon Dots for Dead and Alive Bacterial Imaging

et al. 2023

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“…Given the absence of heavy metals in the structure, ZnS QDs have a long emission lifespan, improved water solubility, and low toxicity, which allows them to be widely used in biological systems. A pH- triggered QDs drug delivery system, described by Mandani et al , was proposed for the antimicrobial application of gentamicin 176 . In this study, MSNs (mesoporous silica nanoparticles) were chosen as gentamicin carriers, and MPA-ZnS QDs were used to encapsulate the nanopores and prevent the premature release of the drug.…”

Section: Quantum Dotsmentioning

confidence: 99%

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

Jiang¹,

Ding²,

Liu³

2023

Theranostics

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Pathogenic bacterial infections represent an ever-growing crisis, now significantly threatening life expectancy across the worldwide population and thus novel approaches to tackle this issue are urgently needed. The application of nanotechnology in recent years has opened up new horizons in the selective or specific delivery of drugs or imaging agents to infectious sites. In particular, the development of nanoparticles for both delivery of active substances and imaging of infection sites is now gathering much interest. Although still in its infancy, the field of antibacterial nanomedicines provides exciting new possibilities to combat multi-resistant bacterial infections and shows great promise for personalized medicine in antibacterial stewardship. This review examines nanoparticle-based formulations used for therapeutic delivery, pathogen tracking in diagnosis, and combined “theranostic” approaches to more effectively treating bacterial infections.

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“…However, strongly acidic media are not recommended as the X-ZnS QDs can be dissociated and the interaction between X ligands and ZnS QDs can be wrecked, leading to a decrease in the stability of QDs [12,28,49]. Therefore, pH = 5.6 has been chosen for the formation of the X-ZnS QDs/TC complex through hydrogen bond and the detection of TC by fluorescence quenching.…”

Section: Optimal Conditions For the Enhanced Fluorescence Detection O...mentioning

confidence: 99%

ZnS quantum dots as fluorescence sensor for quantitative detection of tetracycline

et al. 2022

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Development of a new simple spectroscopic determination coupled acid-motivated delivery system based on fluorescence turn-off MSNs@MPA-ZnS QDs for infection

Cited by 11 publications

References 37 publications

Primary Amine Functionalized Carbon Dots for Dead and Alive Bacterial Imaging

Primary Amine Functionalized Carbon Dots for Dead and Alive Bacterial Imaging

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

ZnS quantum dots as fluorescence sensor for quantitative detection of tetracycline

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