Development of a new polymer network system carrier of essential oils

Chiriac, Aurica P.; Stoleru, Elena; Roșca, Irina; Serban, Alexandru Mihail; Niţă, Loredana E.; Rusu, Alina Gabriela; Ghilan, Alina; Macsim, Ana‐Maria; Mititelu-Tarțău, Liliana

doi:10.1016/j.biopha.2022.112919

Cited by 12 publications

(15 citation statements)

References 17 publications

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“…In one of the mentioned references [ 9 ], the ethylene brassylate homopolymer was synthesised in bulk or solution with benzyl alcohol and various organic compounds as initiation systems, and the study highlighted the interdependence between the molecular mass of the polymer and the catalysts used. Our group investigated the polymerisation of EB with squaric acid (SA) at various rates, and the newly synthesised co-polymacrolactone systems presented increased functionality that opened new opportunities for the application of these compounds [ 20 , 21 ]. SA, a strong acid due to its polar units, is capable of chemical processes, can form intermolecular hydrogen bonds, and, furthermore, can develop polymeric networks with various applications, including medicinal chemistry [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…The use of PEBSA as a biopolymer-based functional structure in a new chemical system also contributes to the diversification of its range of uses. In addition, by using PEBSA, which has already demonstrated its biocompatibility in vivo [ 21 ], in creating a new structure by encapsulating a suitable specific compound, its versatility is highlighted again.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

Chiriac¹,

Ghilan²,

Șerban³

et al. 2022

Antioxidants

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The study presents the achievement of a new assembly with antioxidant behaviour based on a copolymacrolactone structure that encapsulates erythritol (Eryt). Poly(ethylene brassylate-co-squaric acid) (PEBSA) was synthesised in environmentally friendly conditions, respectively, through a process in suspension in water by opening the cycle of ethylene brassylate macrolactone, followed by condensation with squaric acid. The compound synthesised in suspension was characterised by comparison with the polymer obtained by polymerisation in solution. The investigations revealed that, with the exception of the molecular masses, the compounds generated by the two synthetic procedures present similar properties, including good thermal stability, with a Tpeak of 456 °C, and the capacity for network formation. In addition, the investigation by dynamic light scattering techniques evidenced a mean diameter for PEBSA particles of around 596 nm and a zeta potential of −25 mV, which attests to their stability. The bio-based copolymacrolactone was used as a matrix for erythritol encapsulation. The new PEBSA–Eryt compound presented an increased sorption/desorption process, compared with the PEBSA matrix, and a crystalline morphology confirmed by X-ray diffraction analysis. The bioactive compound was also characterised in terms of its biocompatibility and antioxidant behaviour.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

Chiriac¹,

Ghilan²,

Șerban³

et al. 2022

Antioxidants

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“…Moreover, the reducing in intensity of C=O stretching vibration (~1700 cm −1 ) and C–O stretching vibration bands (~1280 cm −1 ) corresponding to PEBSA, settle the above statement. Other bands identified in spectra are: 2925, 2856 and 1460 cm −1 assigned to C–H asymmetric, symmetric and bending vibration; peaks found between 1096 and 1105 cm −1 correspond to asymmetric C–O–C bridge stretching vibration; and C=C bending vibration from squaric acid units identified at 920 and 848 cm −1 [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

“…Our group reported recently the synthesis of poly(ethylene brassylate-co-squaric acid) (PEBSA) performed by ethylene brassylate macrolactone ring-opening and copolycondensing with squaric acid [ 11 ]. In previous studies, our group paid particular attention to this copolymeracrolactone system with different ratios between comonomers [ 11 , 12 , 13 ]. PEBSA, which presents special properties, such as the possibility to create networks, biodegradability and good thermal stability, is also capable of incorporating essential oils—namely thymol (Thy) and carvacrol (CC).…”

Section: Introductionmentioning

confidence: 99%

New Cryogels Based on Poly(vinyl alcohol) and a Copolymacrolactone System: I-Synthesis and Characterization

Crețu¹,

Niţă²,

Șerban³

et al. 2022

Nanomaterials

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Physical cryogels were obtained using the successive freeze–thaw technique of poly(vinyl alcohol) (PVA)/poly(ethylene brassylate-co-squaric acid) (PEBSA) solutions. The cryogel systems were prepared by using two different molecular weights of PVA and PEBSA with three different ratios between the ethylene brassylate (EB) and squaric acid (SA) comonomers. The presence of interactions, the thermal properties and the morphology were investigated using Fourier Transform Infrared Spectroscopy (FT-IR), thermogravimetry (TGA and DTG) and scanning electron microscopy (SEM), respectively. The influence of the composition on the degree of swelling in a physiological environment was demonstrated. The study highlighted improvements in terms of new network flexibility due to the intermolecular chains interactions brought by the introduction of PEBSA in the cryogel structure. We also concluded that the presence of PEBSA in the PVA/PEBSA cryogel network improved the loading capacity of the new system with specific hydrophobic agents, for example essential oils, which (due to their antimicrobial character) can lead to the use of new systems obtained for various applications.

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“…One such compound is 3,4-dihydroxy-3-cyclobutene-1,2-dione, known as squaric acid (SA) [ 38 ]. It has a cyclic structure and was utilized as an effective crosslinker for MNPs coated with chitosan/collagen [ 19 ], and collagen/elastin hydrogels [ 39 ] or in preparing a copolymacrolactone for essential oil encapsulation [ 40 , 41 ]. The influence of SA on the cytotoxicity of collagen/elastin hydrogels was assessed, revealing that SA can be regarded as a safe option [ 39 ] to replace the readily available reagents as GA for enzyme immobilization on amino-functionalized MNPs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Comparative Studies of Glucose Oxidase Immobilized on Fe3O4 Magnetic Nanoparticles Using Different Coupling Agents

Rusu¹,

Chiriac²,

Niţă³

et al. 2022

Nanomaterials

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Squaric acid (SA) is a compound with potential to crosslink biomacromolecules. Although SA has become over the last years a well-known crosslinking agent as a result of its good biocompatibility, glutaraldehyde (GA), a compound with proven cytotoxicity is still one of the most used crosslinkers to develop nanomaterials. In this regard, the novelty of the present study consists in determining whether it may be possible to substitute GA with a new bifunctional and biocompatible compound, such as SA, in the process of enzyme immobilization on the surface of magnetic nanoparticles (MNPs). Thus, a direct comparison between SA- and GA-functionalized magnetic nanoparticles was realized in terms of physico-chemical properties and ability to immobilize catalytic enzymes. The optimal conditions of the synthesis of the two types of GOx-immobilized MNPs were described, thus emphasizing the difference between the two reagents. Scanning Electron Microscopy and Dynamic Light Scattering were used for size, shape and colloidal stability characterization of the pristine MNPs and of those coupled with GOx. Binding of GOx to MNPs by using GA or SA was confirmed by FT-IR spectroscopy. The stability of the immobilized and free enzyme was investigated by measuring the enzymatic activity. The study confirmed that the resulting activity of the immobilized enzyme and the optimization of enzyme immobilization depended on the type of reagent used and duration of the process. The catalytic performance of immobilized enzyme was tested, revealing that the long-term colloidal stability of SA-functionalized MNPs was superior to those prepared with GA. In conclusion, the SA-functionalized bioconjugates have a better potential as compared to the GA-modified nanosystems to be regarded as catalytic nanodevices for biomedical purposes such as biosensors.

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Development of a new polymer network system carrier of essential oils

Cited by 12 publications

References 17 publications

Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

Preparation of an Antioxidant Assembly Based on a Copolymacrolactone Structure and Erythritol following an Eco-Friendly Strategy

New Cryogels Based on Poly(vinyl alcohol) and a Copolymacrolactone System: I-Synthesis and Characterization

Synthesis and Comparative Studies of Glucose Oxidase Immobilized on Fe3O4 Magnetic Nanoparticles Using Different Coupling Agents

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