Development of a New Miticide, Hexythiazox

The economic importance of acaricides in the control of phytophagous mites and an update on recent acaricide mode of action research

“…1). They are particularly valuable because of their excellent eco-toxicological profile, broad spectrum activity and long residual control [63,76,77]. More recently the oxazoline compound etoxazole was introduced as an acaricide [78] (Table 2), and the IRAC group 10 compounds still make up 9% of the market in 2013.…”

Synthesis and Activity of Novel Acaricidal/Insecticidal 2, 4-Diphenyl-1, 3-oxazolines

“…Thus novel acaricides with novel modes of action are important. 12,13) In this study, we synthesized a number of 2,4-diphenyl-1,3-oxazoline derivatives and their analogs having various substituents on the two benzene rings and evaluated their acaricidal activity against two-spotted spider mites ( Tetranichus urticae), secticidal activity against green rice leafhoppers (Nephotettix cincticeps), diamondback moths (Plutella xylostella), and green peach aphids (Myzus persicae). Among various derivatives and analogs, 1-[2-(2,6-difluorophenyl)-1,3-oxazolin-4-yl]-2-ethoxy-4-tent-butylbenzene was selected as an acaricide/ insecticide which was developed into a commercialized product as "etoxazole (ISO)" (Baroque(R)).…”

High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae

“…1b), as both acaricides have been widely used for more than 30 years, and are still valuable tools for mite control. Their popularity is mainly due to an excellent ecotoxicological profile, as they are safe for beneficial insects and predatory mites, and because they provide long residual control (Aveyard et al, 1986; Bretschneider and Nauen, 2008; Yamada et al, 1987). Both compounds further share a broad-spectrum activity against several plant-feeding mite species, including Tetranychus spp and Panonychus spp, and an excellent efficacy on eggs and/or larvae and nymphs (but not adults).…”

“…1c) has similar properties as clofentezine, but the introduction of fluorine atoms in the ortho position of the phenyl ring resulted in improved translocation properties (Pap et al, 1996). Hexythiazox was launched in 1985, soon after clofentezine (Yamada et al, 1987). It quickly became, and continues to be, widely used in integrated pest management programs throughout the world.…”