Development of a New Method for Determination of Sodium Saccharin and Acesulfame Potassium with the Aid of Coagulant

Abstract

An HPLC method for determination of sodium saccharin and acesulfame potassium was newly developed, employing coagulant pretreatment to remove particles dispersed in the sample extract. The method showed recovery of 96-101 for both analytes with a repeatability of less than 1 and a reproducibility of less than 2 . The limit of quantification for sodium saccharin was 0.025 g/kg and that for acesulfame potassium was 0.025 g/kg. Only about 20 min was required for preparation of the test solution, whereas the dialysis method takes much longer.