Development of a New Index Based on Preoperative Serum Lipocalin 2 to Predict Post-LSG Weight Reduction

Abstract

Background Bariatric surgery is the most effective therapy for obesity, but targeted weight reduction is not always achieved. Serum lipocalin-2 (LCN2) is closely associated with obesity, but its impact on weight loss after surgery is unknown. We aimed to access the reliability of LCN2 levels and other parameters as effective predictors of excellent weight loss (≥ 75% excess weight loss (EWL)) 1 year after bariatric surgery. Methods This retrospective study evaluated 450 patients (aged 18–65 years) with obesity at 3 months and 1 year after laparoscopic sleeve gastrectomy (LSG) surgery. Seventy-four patients who underwent LSG surgery and met the inclusion and exclusion criteria were included in this study. Serum LCN2, thyroid function, and metabolic and anthropometric parameters were assessed. Weight reduction was expressed as %EWL and percent total weight loss (%TWL) at 3 months and 1 year post surgery. Multivariable logistic regression analysis and receiver operating characteristic (ROC) curve analysis were used to evaluate predictors of ≥ 75%EWL. Results In our cohort, %EWL and %TWL were both strongly associated with preoperative serum LCN2 levels. The binary logistic regression analysis showed that preoperative LCN2, waist circumference, and glycated hemoglobin were independent predictors of excellent weight loss. Conclusions Based on these results, we determined a new P index with better predictive value for excellent weight reduction (≥ 75%EWL) 1 year after LSG surgery. Graphical abstract

Correlation between Preoperative Dietary Dehavior and Weight Loss after Laparoscopic Sleeve Gastrectomy

“…Although bariatric surgery has been proven to be beneficial in treating obesity, some individuals continue to have poor post-operative weight reduction results. There is still a lot of research being done on the preoperative assessment of obese people, such as preoperative blood indicators, fundic tissue biopsies, and hormone testing for stomach hunger hormones like ghrelin [4][5][6]. Obesity is characterized by an excessive buildup of body fat as a result of https://bcsdjournals.com/index.php/jsrmbs an imbalance between energy intake and energy expenditure, and poor eating habits may play a role in energy intake.…”