Development of a New Herbicide, Fluazifop-butyl

Quantitative Structure-Activity Relationships of Fluazinam and Related Fungicidal <i>N</i>-Phenylpyridinamines

“…Substituent Parameters and QSAR Method Hammett's electronic parameters (crm, 0p), molecular refractivity (MR) and hydrophobic parameter (7r) were taken from literatures. 8, 9) Unreported molecular refractivities were estimated assuming additivity rule defined by MR(OPh-X) = MR(OPh) +MR(X) -MR(H) (1) As for haloalkoxy groups, the it values were estimated by Crippen's method. lo-12) Other unreported hydrophobicities were also estimated assuming the additivity.…”

“…However this compound was found to have high fungicidal activity against rice blast and sheath blight. 4 In this study, structure-activity relationships of this series of compounds were investigated; (1) to understand the role of the substituents on both of the pyridine and the benzene rings of fluazinam and (2) to obtain suggestion about the mode of action of this compound by the techniques of quantitative structure-activity relationships (QSAR) and quantum chemical calculation. Although a QSAR study of fluazinam and its derivatives was published, the study employed uncoupling activity against mitochondria of rat liver.…”

Structure and Fungicidal Activities of 2-Methoxyimino-<i>N</i>-methyl-2-[2-(substituted pyridyloxymethyl)phenyl]acetamide Derivatives

“…The benzene ring of some biologically active compounds can be replaced with heterocyclic structures such as a pyridine or pyrimidine ring without influencing the configuration or the bulkiness of the molecule, and as a consequence of the changes of the physico-chemical characteristics or electronic influences on the molecule, improvement of the biological performance can be obtained. [19][20][21] Therefore, the phenoxymethyl side chain of the 2-methoxyimino-N-methyl-2-[2-(substituted phenoxymethyl)phenyl] acetamide derivatives was replaced with a pyridyloxymethyl group in an attempt to further improve the activity and fungicidal spectrum. This paper deals with the structures and fungicidal activities of the 2-methoxyimino-N-methyl-2-[2-(substituted pyridyloxymethyl)phenyl] acetamide derivatives, with special reference to the effects of the substituents on the pyridine ring.…”

Synthesis and Herbicidal Activity of Pyridinyloxyphenoxypropionamides

“…4 ) We are interested in developing new amide derivatives with strong herbicidal activity, especially by introducing an unnatural amino acid structure into amides. Unnatural amino acid moieties are widely found in the chemical structure of biologically active compounds.…”