Development of a new genotype–phenotype linked antibody screening system
Takashi Watanabe,
Hikaru Hata,
Yoshiki Mochizuki
et al.
Abstract:Antibodies are powerful tools for the therapy and diagnosis of various diseases. In addition to conventional hybridoma-based screening, recombinant antibody-based screening has become a common choice; however, its application is hampered by two factors: 1) screening starts only after Ig gene cloning and recombinant antibody production, and 2) the antibody is composed of paired chains, heavy and light, commonly expressed from two independent expression vectors. Here, we introduce a method for the rapid screenin… Show more
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