Development of a new formulation for direct compression of a natural product

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

“…D-optimal designs provide a different approach to the traditional formulation procedures applied in the development of tablets, as they quantify the effect of the excipients on the final formulation, under the conditions of the study [ 59 ]. They have been previously used to formulate active substances with low flowability and poor tableting behavior [ 19 , 35 , 36 , 37 , 38 ]; however, they have still not been used to develop direct-compressed tablets based on liquid-loaded silica. The main contribution of our study is the use of this methodology to formulate an ME-loaded silica tablet.…”

“…The Artemisia absinthium extract (AAE) was provided by the Research Institute of Agricultural Sciences (ICA) (Madrid, Spain). It was obtained by vapor pressure extraction using a stainless-steel industrial distillation plant [ 38 ]. The resulting extract is composed by mono- and di-terpene components with promising nematocidal properties [ 39 ].…”

“…Response surface methodologies, such as mixture designs, have recently been used in the formulation of microemulsions (ME) [ 25 , 26 , 27 ], self-emulsifying drug delivery systems (SEDDS) [ 28 , 29 , 30 ], liposomes [ 31 , 32 ] and tablets [ 19 , 33 , 34 , 35 , 36 , 37 , 38 ]. The D-optimal design is one of the most used methodologies in this field, because it allows different composition constraints, in which the sum of all components is constant (100% w / w ).…”

Synthesis and Formulation Development of Phenytoin by Inclusion Complexation

“…Five excipients were selected based on their organic properties, particle size, density, compressibility, flow ability, mode of compression and water solubility to optimize powder compatibility, blend uniformity, tablet appearance, tablet weight, tablet hardness, tablet friability and tablet disintegration [30] . As previously reported in the literature, the excipients had no drugexcipients interactions [31][32][33] .…”

Powder Compaction: Compression Properties of Cellulose Ethers

“…MC also demonstrated good compression properties when employed in metronidazole tablets (Itiola & Pilpel, 1991). Maltais et al, (2015) found the compression process produced tablets with a smooth surface when HEC was used. Hence, on these bases, it can be stated that cellulose ethers have good compaction properties and judicious use can improve compressibility of poorly compactable powder mixtures (Shokri and Adibkia, 2013).…”