Development of a new electrochemical sensor for verapamil based on multi-walled carbon nanotube immobilized on glassy carbon electrode

Chamjangali, Mansour Arab; Goudarzi, Nasser; Bagherian, Ghadamali; Reskety, Atiye Ahmadi

doi:10.1016/j.measurement.2015.04.012

Cited by 19 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the mixture of and leukocyte suspension was placed onto the surface of electrode, the shifts of the peak potentials, along with current peaks were both lower than blank potassium ferricyanide solution. The influence of current peak was reported to be associated with the concentration of the solution rather than the types of the solute [ 50 , 51 ]. Huan et al .…”

Section: Discussionmentioning

confidence: 99%

Detection and Identification of Hematologic Malignancies and Solid Tumors by an Electrochemical Technique

Wang

Zhang

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

PurposeDevelop and evaluate an electrochemical method to identify healthy individuals, malignant hematopathic patients and solid tumor patients by detecting the leukocytes in whole-blood.MethodsA total of 114 individual blood samples obtained from our affiliated hospital in China (June 2015- August 2015) were divided into three groups: healthy individuals (n = 35), hematologic malignancies (n = 41) and solid tumors (n = 38). An electrochemical workstation system was used to measure differential pulse voltammetry due to the different electrochemical behaviors of leukocytes in blood samples. Then, one-way analysis of variance (ANOVA) was applied to analyze the scanning curves and to compare the peak potential and peak current.ResultsThe scanning curve demonstrated the specific electrochemical behaviors of the blank potassium ferricyanide solution and that mixed with blood samples in different groups. Significant differences in mean peak potentials of mixture and shifts (ΔEp (mV)) were observed of the three groups (P< = 0.001). 106.00±9.00 and 3.14±7.48 for Group healthy individuals, 120.90±11.18 and 18.10±8.81 for Group hematologic malignancies, 136.84±11.53 and 32.89±10.50 for Group solid tumors, respectively. In contrast, there were no significant differences in the peak currents and shifts.ConclusionsThe newly developed method to apply the electrochemical workstation system to identify hematologic malignancies and solid tumors with good sensitivity and specificity might be effective, suggesting a potential utility in clinical application.

show abstract

Section: Discussionmentioning

confidence: 99%

Detection and Identification of Hematologic Malignancies and Solid Tumors by an Electrochemical Technique

Wang

Zhang

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Indeed, the particular chemical, electrical, mechanical and structural properties of CNTs have led to the development of a variety of detection applications. CNTs promote charge transfer reactions and therefore improve the analytical characteristics of the sensor [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Preconcentration and Successful Selective Detection of Traces of Diclofenac in Water using a Nanostructured Modified Carbon Paste Electrode

et al. 2020

View full text Add to dashboard Cite

A highly sensitive, simple and low cost sensor for the quantification of the diclofenac has been constructed. This sensor consists of a carbon paste nano‐structured by Multi‐Walled Carbon Nanotubes (G‐MWCNT)‐CPE. Scanning electron microscopy (SEM) and voltammetry technique were used to characterize the electrode material and to determine the analytical performances of the sensor in comparison with those obtained at a G‐CPE. The electrochemical oxidation of diclofenac on both G‐CPE and (G‐MWCNT)‐CPE electrodes is mainly controlled by adsorption, presenting a maximum peak current intensity in H2SO4 0.5 mol L−1. The carbon nanotubes, as well as they provide higher conductivity of the paste, act as spacers between the flake graphite particles and avoid their stacking in order to make the surface of graphite particles more accessible to DCF adsorption. The voltammetric measurements of diclofenac on (G‐MWCNT)‐CPE provide a large quantification range from 0.02 to 1 μmol L−1, a detection limit of 0.004 μmol L−1 and quantification limit of 0.014 μmol L−1 under the optimized operating conditions (H2SO4, 0.25 M+KCl 0.25 M, scan rate of 30 mV s−1, preconcentration time 18 min. and MWNTC% (30 %)). The (G‐MWCNT)‐CPE sensor was successfully applied to natural water samples, just acidified with sulfuric acid (pH<1). These samples were doped with diclofenac in sub‐micromolar range and the developed method was validated with excellent recoveries (within a maximum of 3 % difference from 100 %) for all samples indicating no interference effects of the water matrix.

show abstract

“…Some of these reports including fluorimetery, 6 spectrophotometry, 7,8 gas chromatography, [9][10][11][12] ion-chromatography, 13 HPLC, [14][15][16][17][18] HPLC/MS-MS, 19,20 LC-ESI-MS, 21 SPME-LC-ESI-MS, 22 MIP-LC-MS, 23 and electrochemical methods. 24 In spite of higher selectivity presented by above mentioned methods, most of them require sophisticated equipment and are costly, time consuming and also suffer from some disadvantages such as intricate and tedious operational procedure, and high material consumption which is quite inconvenient for for routine clinical applications. It is necessary for future individualized patient treatment to develop a simple, rapid and highly sensitive method for the monitoring of verapamil doses in the biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Direct Monitoring of Verapamil Level in Exhaled Breath Condensate Samples

et al. 2019

View full text Add to dashboard Cite

Background: In this research, an enhanced fluorimetric assay was developed for the direct monitoring of verapamil in exhaled breath condensate (EBC). The method is based on a binding–induced rigidity inside the sodium dodecyl sulfate (SDS) micelle which eliminate collisional quenching and vibrational modes responsible for non-radiative decay. This process produces an enhancement in the emission intensity of verapamil. Methods: Fluorescence intensity measurements were made at 15 ˚C on a FP-750 spectroﬂuorometer with maximum excitation and emission wavelengths of 280 nm and 310 nm, respectively. The important parameters influencing the analytical signal in experimental steps were investigated and optimized. The method was validated with considering of the linearity, recovery and limit of detection. Results: Under the optimized experimental conditions, the calibration graph was linear in the range of 0.02 − 12.0 µg.mL−1 of verapamil with a detection limit of 0.008 µg.mL–1. Conclusion: The proposed method was found to be suitable and accurate for the determination of verapamil and the validated method was successfully used for analysis of verapamil in EBC of patients receiving verapamil with the satisfactory results.

show abstract

Development of a new electrochemical sensor for verapamil based on multi-walled carbon nanotube immobilized on glassy carbon electrode

Cited by 19 publications

References 28 publications

Detection and Identification of Hematologic Malignancies and Solid Tumors by an Electrochemical Technique

Detection and Identification of Hematologic Malignancies and Solid Tumors by an Electrochemical Technique

Preconcentration and Successful Selective Detection of Traces of Diclofenac in Water using a Nanostructured Modified Carbon Paste Electrode

Direct Monitoring of Verapamil Level in Exhaled Breath Condensate Samples

Contact Info

Product

Resources

About