Development of a Nanoparticle System for Controlled Release in Bioprinted Respiratory Scaffolds
Amanda Zimmerling,
Christina Sunil,
Yan Zhou
et al.
Abstract:The use of nanoparticle systems for the controlled release of growth factors is a promising approach to mimicking of the biochemical environment of native tissues in tissue engineering. However, sustaining growth factor release inside an appropriate therapeutic window is a challenge, particularly in bioprinted scaffolds. In this study, a chitosan-coated alginate-based nanoparticle system loaded with hepatocyte growth factor was developed and then incorporated into bioprinted scaffolds. The release kinetics wer… Show more
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