Development of a molecularly imprinted polymer for uric acid sensing based on a conductive azopolymer: Unusual approaches using electrochemical impedance/capacitance spectroscopy without a soluble redox probe

“…Reproduced with permission. [255] Copyright 2021, Elsevier B.V. face of the Fe 3 O 4 /multi-wall carbon nanotubes/SiO 2 support. To examine the anti-interference ability of the sensor, several foreign substances were employed, and the results confirmed the positive impact of MIPs grafting on improving detection selectivity of ECL.…”

Section: Electrochemiluminescence (Ecl) Sensingmentioning

confidence: 99%

mentioning

confidence: 99%

Bio‐Inspired Imprinting Materials for Biomedical Applications

et al. 2022

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Inspired by the recognition mechanism of biological molecules, molecular imprinting techniques (MITs) are imparted with numerous merits like excellent stability, recognition specificity, adsorption properties, and easy synthesis processes, and thus broaden the avenues for convenient fabrication protocol of bio-inspired molecularly imprinted polymers (MIPs) with desirable functions to satisfy the extensive demands of biomedical applications. Herein, the recent research progress made with respect to bio-inspired imprinting materials is discussed in this review. First, the underlying mechanism and basic components of a typical molecular imprinting procedure are briefly explored. Then, emphasis is put on the introduction of diverse MITs and novel bio-inspired imprinting materials. Following these two sections, practical applications of MIPs in the field of biomedical science are focused on. Last but not least, perspectives on the remaining challenges and future development of bio-inspired imprinting materials are presented.

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“…Recently, various Molecularly Imprinted Polymer (MIP) electron sensing substrates have been used in the development of UA sensors, applying distinct electrochemical detection methods. These materials include graphene-doped chitosan [ 15 ], MIPCPE [ 16 ], UA-imprinted-poly(hydroxyethyl-methacrylate-methacryloyl-l-cysteine-methylester)-Fe 3+ [poly(HEMA-MAC)-Fe 3+ ] NPs [ 17 ], uric-acid-imprinted polypyrrole [ 18 ], carbon-enwrapped nickel NPs [ 19 ], MIP-nano-porous Au-leaf [ 20 ], polypyrrole-based MIP [ 21 ] and conductive-azopolymer based MIP [ 22 ]. Photoluminescence spectroscopy [ 23 ], surface plasmon resonance [ 24 ] and photo-electrochemical technique [ 25 ] have also been employed to develop UA sensors.…”

Section: Introductionmentioning

confidence: 99%

An Efficient Enzyme-Less Uric Acid Sensor Development Based on PbO-Doped NiO Nanocomposites

2022

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Here, the voltammetric electrochemical approach was applied to detect uric acid (UA) in a conductive sensing medium (phosphate buffer solution-PBS) by using PbO-doped NiO nanocomposites (NCs)-decorated glassy carbon electrode (GCE) performing as working electrode. The wet-chemically prepared PbO-doped NiO NCs were subjected to characterization by the implementation of XRD, FESEM, XPS, and EDS analysis. The modified GCE was used to detect uric acid (UA) in an enzyme-free conductive buffer (PBS) of pH = 7.0. As the outcomes of this study reveal, it exhibited good sensitivity of 0.2315 µAµM−1cm−2 and 0.2233 µAµM−1cm−2, corresponding to cyclic (CV) and differential pulse (DPV) voltammetric analysis of UA, respectively. Furthermore, the proposed UA sensor showed a wider detection (0.15~1.35 mM) range in both electrochemical analysis methods (CV & DPV). In addition, the investigated UA sensor displayed appreciable limit of detection (LOD) of 41.0 ± 2.05 µM by CV and 43.0 ± 2.14 µM by DPV. Good reproducibility performance, faster response time and long-time stability in detection of UA were perceived in both electrochemical analysis methods. Finally, successful analysis of the bio-samples was performed using the recovery method, and the results were found to be quite acceptable in terms of accuracy. Thus, the findings indicate a reliable approach for the development of 5th generation biosensors using metal-oxides as sensing substrate to fulfill the requirements of portable use for in situ detection.

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Development of a molecularly imprinted polymer for uric acid sensing based on a conductive azopolymer: Unusual approaches using electrochemical impedance/capacitance spectroscopy without a soluble redox probe

Cited by 30 publications

References 51 publications

A novel electrochemical sensor for determination of uric acid in the presence of ascorbic acid and dopamine based on a carbon paste electrode modified with an electrochemically reduced para-nitrobenzoic acid/graphene oxide nanocomposite

A novel electrochemical sensor for determination of uric acid in the presence of ascorbic acid and dopamine based on a carbon paste electrode modified with an electrochemically reduced para-nitrobenzoic acid/graphene oxide nanocomposite

Bio‐Inspired Imprinting Materials for Biomedical Applications

An Efficient Enzyme-Less Uric Acid Sensor Development Based on PbO-Doped NiO Nanocomposites

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