Development of a modified – solid dispersion in an uncommon approach of melting method facilitating properties of a swellable polymer to enhance drug dissolution

Nguyen, Tuong Ngoc-Gia; Tran, Phuong Ha-Lien; Tran, Thanh Van; Vo, Toi Van; Truong-DinhTran, Thao

doi:10.1016/j.ijpharm.2015.02.064

Cited by 19 publications

(3 citation statements)

References 24 publications

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“…The final pellets were resuspended in 200 µL of filtered PBS and stored at −20 °C for further experiments. Drug concentrations were determined by HPLC [ 33 ]. The percentage of drug loading and entrapment efficiency were calculated as follow:

…”

Section: Methodsmentioning

confidence: 99%

Development of Blueberry-Derived Extracellular Nanovesicles for Immunomodulatory Therapy

Nguyen,

Pham,

Chowdhury

et al. 2023

Pharmaceutics

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Over the past decade, there has been a significant expansion in the development of plant-derived extracellular nanovesicles (EVs) as an effective drug delivery system for precision therapy. However, the lack of effective methods for the isolation and characterization of plant EVs hampers progress in the field. To solve a challenge related to systemic separation and characterization in the plant-derived EV field, herein, we report the development of a simple 3D inner filter-based method that allows the extraction of apoplastic fluid (AF) from blueberry, facilitating EV isolation as well as effective downstream applications. Class I chitinase (PR-3) was found in blueberry-derived EVs (BENVs). As Class I chitinase is expressed in a wide range of plants, it could serve as a universal marker for plant-derived EVs. Significantly, the BENVs exhibit not only higher drug loading capacity than that reported for other EVs but also possess the ability to modulate the release of the proinflammatory cytokine IL-8 and total glutathione in response to oxidative stress. Therefore, the BENV is a promising edible multifunctional nano-bio-platform for future immunomodulatory therapies.

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…”

Section: Methodsmentioning

confidence: 99%

Development of Blueberry-Derived Extracellular Nanovesicles for Immunomodulatory Therapy

Nguyen,

Pham,

Chowdhury

et al. 2023

Pharmaceutics

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“…On scouring the literature, it is observed that PVP and PEG are most popularly used polymers for the preparation of solid dispersion 33 . Low melting point of PEG (50-60 o C) and rapid solidification offers it to be used in forming solid dispersion 25 while the PVP K-30 is high melting point (150-180 o C) and small its molecular weight render it to be a suitable carrier in achieving high dissolution 34 .…”

Section: Introductionmentioning

confidence: 99%

Development, characterisation and evaluation of pvp k-30/peg solid dispersion containing ketoprofen

Bhatia¹,

Devi²

2020

actapharm

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The present study is designed with the objective to enhance the aqueous solubility of ketoprofen. For the said purpose solid dispersion employing PVP K-30 and PEG 6000 is prepared by hot melt method. The preparation of solid dispersion (SD) was optimized using 2-factor, 3 level central composite design. The preparation of SD was characterized by FTIR, DSC, XRD and SEM studies. Further, solubility, Gibb ' s energy and in vitro release study was determined for different batches of the formulation as suggested by the design expert. The solubility of different batches of SD was found to be between 36.2 to 53.0μg/ml whereas pure drug and physical mixture possess the solubility of 14.4 and 23.8 μg/mL, respectively. The in vitro release is found to be 76.74 to 95.32% and PM shows 75.4 % release and pure drug shows 23.5 % release. Thus, the ketoprofen-loaded solid dispersion would be useful for delivering poorly water-soluble ketoprofen with enhanced dissolution, solubility and no crystalline changes.

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“…Advantages of polymers such as hydroxypropyl methycellulose and polyethylene oxide are hydrophilic and swellable properties which can be utilized in increasing dissolution rate (4)(5)(6)(7)(8)(9)(10)(11) and modulating drug release profiles (12)(13)(14)(15)(16). The application of these two polymer properties in one system could facilitate the design of a dual function drug delivery system by preparation of SD for dissolution enhancement and compression of matrix tablets for sustained release (3,17). Regarding conventional SDs, there are still some disadvantages to deal with the preparation methods.…”

Section: Introductionmentioning

confidence: 99%

Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method

Nguyen

Tran

et al. 2015

Pharm Res

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Development of a modified – solid dispersion in an uncommon approach of melting method facilitating properties of a swellable polymer to enhance drug dissolution

Cited by 19 publications

References 24 publications

Development of Blueberry-Derived Extracellular Nanovesicles for Immunomodulatory Therapy

Development of Blueberry-Derived Extracellular Nanovesicles for Immunomodulatory Therapy

Development, characterisation and evaluation of pvp k-30/peg solid dispersion containing ketoprofen

Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method

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