Development of a model to induce transient synovitis and lameness in the hip joint of dogs

Hassan, Elham A.; Lambrechts, Nicolaas E.; Moore, George E.; Weng, Hsin‐Yi; Heng, Hock Gan; Breur, Gert J.

doi:10.2460/ajvr.76.10.869

Cited by 3 publications

(2 citation statements)

References 27 publications

(33 reference statements)

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“…In humans, most pain occurs within 24 h, and symptoms resolve within 14 days even without treatment ( 16 , 17 ). Similarly, Hassan et al reported the symptoms to be most severe at 4 h and relieved after 24 h in the dogs when a sodium urate suspension is injected intra-articularly ( 18 ). The owners of the animals in this case report also described the symptoms as intermittent or shifting lameness, similar to the time course of symptomatic episodes that can be seen in humans.…”

Section: Discussionmentioning

confidence: 97%

Case Report: Articular Gout in Four Dogs and One Cat

et al. 2022

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BackgroundThere is widespread prejudice in veterinary medicine that gout does not occur in non-human mammalians. However, we recently discovered monosodium urate crystals in the synovial fluid obtained from a few dogs and a cat. Since it is the definitive and gold standard to diagnose gout, we report these cases as newly emerging diseases in companion animals.Case PresentationFour dogs and one cat were presented at our hospital because of lameness due to an unknown cause. Even after the routine examinations, including radiographic imaging, laboratory examination, and arthrocentesis, we were unable to find a clear cause of polyarthritis. However, we later discovered monosodium urate crystals in the synovial fluid of the animals, confirmed by polarized microscopy. In one of the two dogs treated with immunosuppressants, the disease relapsed, and the other did not show any symptoms for 3 months. The other two dogs were treated with xanthine oxidase inhibitor, where one died, and the other did not show any symptoms for 3 years. The cat was treated with drainage and intra-articular dexamethasone injection, but the disease recurred after 6 months.ConclusionThis is the first report to confirm that articular gout can occur in dogs and cats. Care must be taken not to neglect needle-shaped materials in the synovial fluid. Gout should also be included in the differential diagnosis of arthritis and further research is needed in these animals.

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Section: Discussionmentioning

confidence: 97%

Case Report: Articular Gout in Four Dogs and One Cat

et al. 2022

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“…Ideally, a valuable animal model for this inflammatory-related disease should be suitable for the evaluation of immune biomarkers and kinematic parameters. At the present, several animal models of synovitis have been described including dogs [15], rats [16] and rabbits [17]. However, due to their translational applicability, other large animal models such as pigs or sheep have been considered as the more appropriate models for this kind of studies [18].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies

et al. 2017

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BackgroundSynovitis is an inflammation-related disease linked to rheumatoid arthritis, osteoarthritis, infections and trauma. This inflammation is accompanied by immune cells infiltration which initiates an inflammatory response causing pain, discomfort and affecting the normal joint function. The treatment of synovitis is based on the administration of anti-inflammatory drugs or biological agents such as platelet rich plasma and mesenchymal stem cells. However, the evaluation and validation of more effective therapies of synovitis requires the establishment of clinically relevant animal models.ResultsIn this study, Large White pigs were pre-immunized to evaluate an antigen-induced synovitis. The immune monitoring of synovial fluids in this model allowed us the identification of IL-12p40 and T cell subsets as immune biomarkers. Moreover, the evolution of synovitis was performed by arthroscopic procedures and kinetic analysis. In summary, this paper describes an animal model of antigen-induced synovitis to be used in the evaluation of anti-inflammatory therapies.ConclusionsThe novelty of this paper lies in the development of a clinically relevant model of synovitis which permits the simultaneous evaluation of synovitis from an immunological, surgical and kinetic point of view.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-1025-4) contains supplementary material, which is available to authorized users.

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Effects of denervation of the hip joint on results of clinical observations and instrumented gait analysis in dogs with sodium urate crystal–induced synovitis

Hassan¹,

Lambrechts²,

Weng³

et al. 2016

ajvr

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OBJECTIVE To evaluate the effects of selective hip joint denervation on gait abnormalities and signs of hip joint pain in dogs. ANIMALS 6 healthy adult hound-type dogs. PROCEDURES Minimally invasive denervation was performed on the right hip joint of each dog. Two weeks later, sodium urate was injected into the right hip joint to induce synovitis. Dogs were evaluated clinically and by use of instrumented gait analysis before and 2 weeks after minimally invasive denervation and 4, 8, and 24 hours after induction of synovitis. Dogs were euthanized, and necropsy and histologic examination were performed. RESULTS No kinetic or kinematic gait modifications were detected 2 weeks after minimally invasive denervation. Denervation did not eliminate signs of pain and lameness associated with sodium urate-induced synovitis. Results of histologic examination confirmed that denervation was an effective method for transecting the innervation of the craniolateral and caudolateral aspects of the hip joint capsule. CONCLUSIONS AND CLINICAL RELEVANCE In this study, minimally invasive denervation did not result in gait modifications in dogs. Denervation did not abolish the signs of pain and lameness associated with generalized induced synovitis of the hip joint. Further studies are required before conclusions can be drawn regarding the clinical usefulness of hip joint denervation for dogs with hip dysplasia.

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Development of a model to induce transient synovitis and lameness in the hip joint of dogs

Cited by 3 publications

References 27 publications

Case Report: Articular Gout in Four Dogs and One Cat

Case Report: Articular Gout in Four Dogs and One Cat

Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies

Effects of denervation of the hip joint on results of clinical observations and instrumented gait analysis in dogs with sodium urate crystal–induced synovitis

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