Development of a microbicide-releasing diaphragm as an HIV prevention strategy

Major, Ian; Lowry, Deborah; Malcolm, Karl; Woolfson, David; Cohen, Jessica; LaBarre, Paul; Kilbourne-Brook, Maggie; Saxon, Gene; Friend, David R.

doi:10.1109/iembs.2010.5627333

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…Nevertheless, they do still provide a control to demonstrate that the sperm were motile and capable of traversing a membrane with 3 μm diameter pores. Relying upon a porous mesh to block sperm penetration differs from current barrier approaches, which rely on nonporous materials to block sperm entry into the cervix [52]–[54]. Our results showed that a porous, tortuous mesh fabricated by electrospinning could efficiently block sperm entry.…”

Section: Discussionmentioning

confidence: 77%

Drug-Eluting Fibers for HIV-1 Inhibition and Contraception

et al. 2012

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Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually transmitted infections (STIs) and unintended pregnancy are a global health priority. Combining chemical and physical barriers offers the greatest potential to design effective MPTs, but integrating both functional modalities into a single device has been challenging. Here we show that drug-eluting fiber meshes designed for topical drug delivery can function as a combination chemical and physical barrier MPT. Using FDA-approved polymers, we fabricated nanofiber meshes with tunable fiber size and controlled degradation kinetics that facilitate simultaneous release of multiple agents against HIV-1, HSV-2, and sperm. We observed that drug-loaded meshes inhibited HIV-1 infection in vitro and physically obstructed sperm penetration. Furthermore, we report on a previously unknown activity of glycerol monolaurate (GML) to potently inhibit sperm motility and viability. The application of drug-eluting nanofibers for HIV-1 prevention and sperm inhibition may serve as an innovative platform technology for drug delivery to the lower female reproductive tract.

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Section: Discussionmentioning

confidence: 77%

Drug-Eluting Fibers for HIV-1 Inhibition and Contraception

et al. 2012

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“…Additional female controlled methods are also in development (e.g., microbicide-releasing diaphragm or vaginal ring). The diaphragm would offer a means of contraception and HIV prevention controlled by the woman, and a vaginal ring would offer long-term protection for women; however, both are dependent on a proven effective microbicide (Major et al, 2010).…”

Section: Microbicidesmentioning

confidence: 99%

Sexuality and HIV/AIDS prevention.

Bauermeister¹,

Elkington²,

Huebner³

2014

APA Handbook of Sexuality and Psychology, Vol. 1: Person-Based Approaches.

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“…The drug loaded core can be viewed as a vaginal ring that allows permeation of drugs from the thermoplastic core through the silicone sheath layer while the diaphragm itself acts a barrier contraceptive. Queen's University Belfast (QUB) has developed prototypes of this multi-prevention device using UC781 (Major et al 2010) dispersed in polyoxymethylene (POM) copolymer. Additionally, QUB initiated development of dapivirine-loaded POM spring cores of the SILCS contraceptive diaphragm (Major et al 2012).…”

Section: Silcs Diaphragmmentioning

confidence: 99%

Microbicide Dosage Forms

Rohan

Devlin

Yang

2013

Current Topics in Microbiology and Immunology

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Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become important to have longer acting products to minimize the burden of user compliance and thus vaginal rings have been developed providing sustained delivery of antiretroviral drugs. This chapter discusses the history of microbicides along with a detailed description of coitally dependent products, gels, films, tablets diaphragms, as well as coitally independent dosage forms such as vaginal rings and the introduction of a new technology, electrospun fibers.

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Development of a microbicide-releasing diaphragm as an HIV prevention strategy

Cited by 6 publications

References 16 publications

Drug-Eluting Fibers for HIV-1 Inhibition and Contraception

Drug-Eluting Fibers for HIV-1 Inhibition and Contraception

Sexuality and HIV/AIDS prevention.

Microbicide Dosage Forms

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