Development of a method to screen and isolate xanthine oxidase inhibitors from black bean in a single step: Hyphenation of semipreparative liquid chromatography and stepwise flow rate countercurrent chromatography

Niu, Huazhou; Liu, Chunming; Hou, Wanchao; Li, Sainan; Zhang, Yuchi; Liu, Zhen; Yun, Haocheng

doi:10.1002/jssc.202100663

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…It also relieved the swelling of the ankle joints and decreased inflammatory cell infiltration around the ankle joints. These studies indicate that this plant has the potential to reduce hyperuricemia (Zhang et al 2022).…”

Section: Moroccon Medicinal Plantsmentioning

confidence: 89%

“…The aqueous extract of Dendrobium candidum leaves (DLE) could decrease the level of uric acid in rats was found through a study. The therapeutic efficacy of the Dendrobium candidum leaf extract on hyperuricemia was investigated (Zhang et al 2022). The results indicated that biochemical parameters of kidney and liver function, specifically uric acid levels in serum, were ameliorated with DLE, which may be related to a reduction of XO and adenosine deaminase (ADA) in the liver.…”

Section: Dendrobium Candidummentioning

confidence: 99%

“…In medicinal plants presence of phenolic and flavonoid compounds is reported to possess antigout activity. A study was designed to optimize the extraction conditions of flavonoid and phenolic compounds and unravel the anti-gout potential (XO inhibitory activity) of Euphorbia hirta through in-vitro studies using response surface methodology (RSM) (Niu et al 2022). The optimum values for total flavonoid, total phenolic, and XO inhibitory activity were 67.56 mg RE/g, 155.21 mg GAE/g, and 91.42%, respectively.…”

Section: Euphorbia Hirta L (Ara Tanah)mentioning

confidence: 99%

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Search for the Natural Remedies for the Treatment of Gout

Bibi,

Shahid,

Ain

2022

Phytopharmacological Com.

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Gout is a well-known form of inflammatory arthritis, a condition that develops due to excessive synthesis and reduced excretion of uric acid. Extensively upregulated uric acid levels in the body culminate in the build-up of uric acid crystals in joints, tissues, and body fluids. Pain in the joints, heart, skin redness, and swelling, particularly at the base of the big toe, are the cardinal features. Permanent joint damage may occur if gout is left untreated. Even though many drugs are established for gout therapy, these drugs cannot impede or reverse disease progression. Moreover, chronic use of these anti-gout agents is associated with several undesirable effects. A safe alternative to these synthetic drugs can be natural remedies. These natural remedies are found to subside symptoms of gout efficiently with the additional benefit of minimum or no side effects even after prolonged use. Traditional Chinese medicines have demonstrated better effects against gout than conventional therapies. The medicinal property of Malaysian and Morocco medicinal plants, Apium graveolens, Dendrobium candidum, Aristolochia baetica, Aristolochia paucinervis, Prunus avium, Prunus cerasus, Paullinia pinnata, Euphorbia hirta and Coffea arabica against gout are summarized in this article. This article aims to highlight the importance of these medicinal plants as a safe alternative to current conventional therapies against gout.

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Section: Moroccon Medicinal Plantsmentioning

confidence: 89%

Section: Dendrobium Candidummentioning

confidence: 99%

Section: Euphorbia Hirta L (Ara Tanah)mentioning

confidence: 99%

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Search for the Natural Remedies for the Treatment of Gout

Bibi,

Shahid,

Ain

2022

Phytopharmacological Com.

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“…It accounted for 15.81% of the constituents in an extract of Puerariae flos and was the component of the extract with the greatest ability to inhibit XO (the other components are tectoridin, ononin, and biochanin A) (Liu et al., 2017). Genistein and daidzein are the main active substances in soybean okara, black bean and P. lobata roots, and potential functional ingredients that may act as natural therapeutic agents for conditions involving XO (Nile et al., 2020; Niu et al., 2022; Tang et al., 2020).…”

Section: Mechanism Of Xo Activity and Hua Inhibition By Flavonoidsmentioning

confidence: 99%

Mechanism of flavonoids inhibiting xanthine oxidase and alleviating hyperuricemia from structure–activity relationship and animal experiments: A review

Xue

Gong

et al. 2023

Food Frontiers

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Hyperuricemia (HUA) is a metabolic disease caused by excessive uric acid in patients. Flavonoids have attracted extensive attention due to their safety, effectiveness, and little side effects in the treatment of HUA and inhibition of xanthine oxidase (XO) activity. In this paper, the studies on the treatment of HUA and the inhibition of XO activity by flavonoids (including flavones, flavonols, flavanones, flavanols, isoflavonoids, anthocyanins, and chalcones) were comprehensively reviewed from the aspects of structure–activity relationship and animal experiments. Results showed that hydrogen bonds and hydrophobic interactions were the two most important forces involved in the interaction between flavonoids and XO. Flavonoids could combine with the hydrophobic cavity of XO to cause changes in XO structure and influence the action of enzyme and substrate, thereby decreasing the catalytic activity of XO. Moreover, flavonoids undergo a series of metabolic reactions in the organism, which plays a role in alleviating HUA by affecting the expression of related genes and proteins (e.g., glucose transporter 9, urate transporter 1, and organic anion transporter 1) in the kidneys, liver, and intestinal tract of the organism and changing the internal environment in organs. In addition, this paper provides new perspectives on the shortcomings of the current research, to promote the in‐depth development and application of flavonoids.

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Magnetic surface molecularly imprinted polymers for efficient selective recognition and targeted separation of daidzein

Wang,

Kuang,

et al. 2023

Adv Compos Hybrid Mater

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Development of a method to screen and isolate xanthine oxidase inhibitors from black bean in a single step: Hyphenation of semipreparative liquid chromatography and stepwise flow rate countercurrent chromatography

Abstract: Development of a method to screen and isolate xanthine oxidase inhibitors from black bean in a single step: hyphenation of semipreparative liquid chromatography and stepwise flow rate countercurrent chromatography.

Cited by 5 publications

References 25 publications

Search for the Natural Remedies for the Treatment of Gout

Search for the Natural Remedies for the Treatment of Gout

Mechanism of flavonoids inhibiting xanthine oxidase and alleviating hyperuricemia from structure–activity relationship and animal experiments: A review

Magnetic surface molecularly imprinted polymers for efficient selective recognition and targeted separation of daidzein

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