Development of a method for the analysis of drugs of abuse in vitreous humor by capillary electrophoresis with diode array detection (CE–DAD)

A simple and fast method for determination of benzocaine and lidocaine in pharmaceutical formulations by capillary electrophoresis with spectrophotometric detection

“…The proposed method demonstrated to be very sensitive, as indicated by the low values (below 1 mg L −1 ) of the LOQ obtained. These LOQs were lower or comparable to those reported in previous works using CE [33,36,37,43], HPLC [12][13][14][15][16][17][18][19][20][21][22], and electrochemical detection [23,[25][26][27]. The intra-day precision was assessed by analyzing in triplicate (in the same day) six different samples of pharmaceutical formulations (three samples containing LD and other three with BZ).…”

“…In addition to HPLC methods of analysis for determination of LD and BZ in pharmaceutical formulations [12][13][14][15][16][17][18][19][20][21][22], analytical methods based on electrochemical [23][24][25][26][27] and spectrophotometric [28][29][30][31] detections have also been reported in the literature. Beyond quantification of LD in pharmaceutical formulations [32][33][34][35], CE has also been applied for the determination of this anesthetic in urine [36][37][38], human plasma [39,40], human serum [41,42], vitreous humor [43], and seized cocaine [6,9]. However, to the best of our knowledge, there are no reports in the literature about the determination of BZ by CE.…”

Rapid electrophoretic monitoring of the anaesthetic ketamine and its metabolite norketamine in rat blood using a contactless conductivity detector to study the pharmacokinetics

“…Direct UV spectrometry of the underivated analyte is used for detection of ketamine in CE. The absorption of ketamine itself in the UV region is, however, low, with a poorly defined maximum at an unselective wavelength of around 200 nm . CE/UV determination of ketamine has been used in the analysis of model samples with sufficiently high concentrations of ketamine; the analysis of clinical samples requires more complicated matrix preparation entailing evaporation of the sample to dryness, which substantially complicates the actual determination .…”

Ultrafast capillary electrophoresis/mass spectrometry of controlled substances with optical isomer separation in about a minute

“…In forensic chemistry, CE has been used for toxicological drug analysis and for the analysis of seized drugs. In forensic toxicology, CE has been used for the identification of drugs and their metabolites in various body fluids . One advantage of CE is that it allows for the separation of a wide range of compounds usually by simply changing the background electrolyte .…”

“…In forensic toxicology, CE has been used for the identification of drugs and their metabolites in various body fluids. [11,12] One advantage of CE is that it allows for the separation of a wide range of compounds usually by simply changing the background electrolyte. [8] Like LC, CE does not require derivatization of analytes and the thermal stability of the compounds is not an issue.…”