Development of a Magnetic Nanostructure for Co-delivery of Metformin and Silibinin on Growth of Lung Cancer Cells: Possible Action Through Leptin Gene and its Receptor Regulation

Javan, Elnaz Salmani; Lotfi, Fatemeh; Jafari-Gharabaghlou, Davoud; Mousazadeh, Hanieh; Dadashpour, Mehdi; Zarghami, Nosratollah

doi:10.31557/apjcp.2022.23.2.519

Cited by 35 publications

(16 citation statements)

References 47 publications

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“…Despite this, as such compounds constitute roughly 70 percent of all anticancer drugs. Curcumin and chrysin are two of plant compounds that are under focus these days in many anticancer researches (Mohammadinejad et al, 2015b;Bhatia et al, 2021;Alagheband et al, 2022;Salmani Javan et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Development of PEGylated PLGA Nanoparticles Co-Loaded with Bioactive Compounds: Potential Anticancer Effect on Breast Cancer Cell Lines

Mohammadinejad

Jafari-Gharabaghlou

Zarghami

2022

Asian Pac J Cancer Prev

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Objective:The incidence of breast cancer continues to rise despite decades of laboratory, epidemiological and clinical research. Breast cancer is still the leading cause of cancer death in women. Cyclin D1 is one of the most important oncoproteins associated with cancer cell proliferation and is overexpressed in more than 50% of cases. Curcumin and chrysin are plant-derived components that are believed to assist in inhibiting the viability of breast cancer cells. These agents are involved in cancer cells' growth and reducing cyclin D1 expression. In this study, the hypothesis of combining curcumin and chrysin is applied to analyze the potential synergistic effect in inhibiting cancer cell proliferation and down-regulation of cyclin D1. Furthermore, applying PLGA-PEG NPs could improve the bioavailability of free curcumin and chrysin components and at the same time increases the anti-cancer potential of this compound. Methods: PLGA-PEG NPs were synthesized via the ring-opening polymerization technique and characterized with FT-IR and FE-SEM for chemical structure and morphological characteristics, respectively. Next, curcumin and chrysin were loaded in PLGA-PEG NPs and MTT assay was performed to assess the cytotoxic effect of these agents. T-47D cells were treated with appropriate concentrations of these agents and cyclin D1 expression level was evaluated by real-time PCR. Results: The obtained results from FT-IR and FE-SEM techniques illustrated that curcumin and chrysin were efficiently encapsulated into PLGA-PEG NPs. Curcumin, chrysin, and curcumin-chrysin in free and nano-encapsulated forms exhibited an anti-cancer effect on T-47D cells in a time-and dose-dependent manner, especially in a combination of free and encapsulated forms demonstrated synergistic anti-cancer effects. Compared to free form, Nano-curcumin, Nano-chrysin, and Nano-combination remarkably down-regulated cyclin D1 gene expression. (p-value < 0.05). Conclusion: Our results revealed that the curcumin-chrysin combination has a synergistic effect and the encapsulated form of this nano-component has more inhibition on cyclin D1 expression.

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Section: Introductionmentioning

confidence: 99%

Development of PEGylated PLGA Nanoparticles Co-Loaded with Bioactive Compounds: Potential Anticancer Effect on Breast Cancer Cell Lines

Mohammadinejad

Jafari-Gharabaghlou

Zarghami

2022

Asian Pac J Cancer Prev

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“…Studies on the effect of LEPR on the progression of lung cancer have been widely reported [31,32] , especially in NSCLC [33] . Previous studies have focused on activating leptin receptor pathway, which can improve blood glucose and anxiety behavior in diabetes mice [34] .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of Major depression Related gene Signature for predicting prognosis in lung adenocarcinoma

Xue

Chen

Huang

et al. 2023

Preprint

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Background Lung adenocarcinoma (LUAD) is one of the most common types of cancer in the world, which has attracted much attention due to its high heterogeneity, invasiveness and metastasis. In recent years, depression has been proved to be related to the occurrence and development of various tumors. However, the regulatory pathway of depression related genes on tumor immune microenvironment and how the underlying mechanisms affect the prognosis of LUAD patients remain unclear. Methods In this study, we obtained common differentially expressed genes of LUAD patients and MDD patients through R software package "Limma". The relationship between Co-dysregulated genes and metabolism was investigated by KEGG enrichment analysis. According to survival analysis, we screened and constructed Diffgene | Neuropeptides related to prognosis. Finally, the prediction model is constructed using the LASSO algorithm and Cox regression, and its prediction ability is verified. Results This study constructed a risk assessment model for LUAD patients based on the 9 neuropeptide genes most related to the prognosis of lung adenocarcinoma, and showed significant predictive effect. The enrichment analysis results of MDD and LUAD Co-dysregulated genes obtained show that the up-regulated genes are enriched in Axon guidance, Ras signaling path, MAPK signaling path, and the down-regulated genes are significantly enriched in Jak-STAT signaling path, Fc epsilon RI signaling path. The results of single cell sequencing data analysis showed that in the high-risk population, it was significantly enriched with ethoxylates, dicarboxylic acid metabolism and pentose phosphate pathway. The low-risk group was more inclined to glycosaminoglycan synthesis, heparin sulfate metabolism and vitamin B6 metabolism. Conclusions In general, our study proves for the first time that MDD related gene play an important role in the prognosis of LUAD. The personalized evaluation based on Diffgene | neuropeptide scoring model can accurately predict the prognosis of LUAD patients.

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“…Magnetic nanoparticles (MNPs) are different from the other nanocarriers owing to the magnetic features that make them unique for drug delivery [ 71 ]. Drug molecules could be conjugated to the MNPs shell to be introduced into the body and be concentrated in a local region due to the impact of an external magnetic field.…”

Section: Applications Of Nano-based Materials For Ocular Drug Deliverymentioning

confidence: 99%

Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

2022

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Ocular drug delivery is one of the most challenging endeavors among the various available drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic disease, we have not yet succeeded in achieving a proper drug delivery approach with the least adverse effects. Nanotechnology offers great opportunities to overwhelm the restrictions of common ocular delivery systems, including low therapeutic effects and adverse effects because of invasive surgery or systemic exposure. The present review is dedicated to highlighting and updating the recent achievements of nano-based technologies for ocular disease diagnosis and treatment. While further effort remains, the progress illustrated here might pave the way to new and very useful ocular nanomedicines.

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Development of a Magnetic Nanostructure for Co-delivery of Metformin and Silibinin on Growth of Lung Cancer Cells: Possible Action Through Leptin Gene and its Receptor Regulation

Cited by 35 publications

References 47 publications

Development of PEGylated PLGA Nanoparticles Co-Loaded with Bioactive Compounds: Potential Anticancer Effect on Breast Cancer Cell Lines

Development of PEGylated PLGA Nanoparticles Co-Loaded with Bioactive Compounds: Potential Anticancer Effect on Breast Cancer Cell Lines

Comprehensive analysis of Major depression Related gene Signature for predicting prognosis in lung adenocarcinoma

Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

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