Development of a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of epigallocatechin-3-gallate, silibinin, and curcumin in plasma and different tissues after oral dosing of Protandim in rats and its application in pharmacokinetic and tissue distribution studies

Song, Ying; Sun, Huijing; Xiao, Jie; Fan, Wei; Ding, Yi; Zhao, Jing; Bai, Juan; Cheng, Lianghua; Gao, Kai; Liu, Meiyou; Guo, Qiyan; Zhang, Yanmin; Gao, Wei; Jia, Yi‐Xia; Wen, Aidong

doi:10.1016/j.jpba.2019.03.024

Cited by 10 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result is a self-emulsifying non-covalent molecular complex Review: bioavailability and efficacy of 'free' curcuminoids of curcumin and fenugreek galactomannans that converts the insoluble crystalline curcumin to amorphous, water-dispersible and stable 'curcumagalactomannoside'. The microparticle with a size of less than 150 μm renders it a reversible hydrogel with high swelling index, optimum hydrophobic-hydrophilic balance and amphiphilicity that confers both protection from intestinal conjugation and an increase in the absorption of 'free' curcuminoids into bloodstream (20,21) . As a water-only-based process, FENUMAT ® formulation technology is considered the first 'green' approach in phytonutrient delivery.…”

Section: Fenumat ® Patented Technologymentioning

confidence: 99%

Review: bioavailability and efficacy of ‘free’ curcuminoids from curcumagalactomannoside (CGM) curcumin formulation

Matthewman

Krishnakumar²,

Swick

2023

Nutr. Res. Rev.

View full text Add to dashboard Cite

The golden spice turmeric with its main bioactive component curcumin is one of the most popular and extensively studied nutraceuticals. Despite numerous preclinical studies reporting positive pharmacodynamics of turmeric extracts and curcumin, the main issues in translating the pharmacological effects to clinical efficacy have been to overcome its poor pharmacokinetics and to deliver significant amounts of the biologically relevant forms of the actives to various tissues. This review is aimed at providing a first critical evaluation of the current published literature with the novel curcumagalactomannoside (CGM) formulation of curcumin using fenugreek galactomannan dietary fiber, specifically designed to address curcumin poor pharmacokinetics. We describe CGM and its technology as a food-grade formulation to deliver ‘free’ unconjugated curcuminoids with enhanced bioavailability and improved pharmacokinetic properties. The therapeutic relevance of improving bioavailability of ‘free’ curcuminoids and some of the technical challenges in the measurement of the ‘free’ form of curcuminoids in plasma and tissues are also discussed. A total of 26 manuscripts are reviewed here, including 14 preclinical and 12 clinical studies that have investigated CGM pharmacokinetics, safety, and efficacy in various animal models and human conditions. Overall current scientific evidence suggests CGM formulation has improved bioavailability and tissue distribution of the biologically relevant unconjugated forms of turmeric actives called “free” curcuminoids that may be responsible for the superior clinical outcomes reported with CGM treatments in comparison with unformulated standard curcumin across multiple studies.

show abstract

Section: Fenumat ® Patented Technologymentioning

confidence: 99%

Review: bioavailability and efficacy of ‘free’ curcuminoids from curcumagalactomannoside (CGM) curcumin formulation

Matthewman

Krishnakumar²,

Swick

2023

Nutr. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…This method involves the analysis of proteins and peptides in the samples to achieve the identification, characterization, and quantification of allergens. By bypassing immune reactions, the detection process effectively mitigates the risk of cross-allergic responses ( Song, Sun, Xiao, Wang, Ding, Zhao, et al, 2019 ). Prandi et al, (2013) employed LC-MS-MS to analyze the sensitization of LTPs and X5 gliadin in wheat.…”

Section: Introductionmentioning

confidence: 99%

Study on the reduction of Tartary buckwheat allergenicity during Pediococcus pentosaceus fermentation by HPLC-MS/MS analysis

Zhou,

Yu,

She

et al. 2023

Food Chemistry: X

View full text Add to dashboard Cite

“…There is several instrumental technique to determine of curcumin compound such as, including ultraviolet-visible spectroscopy (UV/Vis) (Emre Unsal et al, 2019), isocratic highperformance liquid chromatography (HPLC), high-performance liquid chromatography with ultraviolet detection (HPLC-UV) (Khorshidi et al, 2020) and fluorescence (HPLC-FLD) (Schiborr et al, 2010), ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS) (Sandhiutami et al, 2021), reversed-phase liquid chromatography (RPLC) (Rodriguez et al, 2021), liquid chromatography-tandem mass spectrometry (LC-MS/MS) (Song et al, 2019) ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) (Yu et al, 2019), capillary electrophoresis with amperometric detection (CE-AD) (Sun et al, 2002), electrochemical sensors (Raril et al, 2020) and supramolecular solvent-based liquid-liquid microextraction (SMS-LLME) (Caleb & Alshana, 2021).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Analysis Methods for Curcumin Determination: A Literature Review

Japar Sodik,

Dinata,

Kusriani

et al. 2023

View full text Add to dashboard Cite

Curcuminoids such as curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are the major bioactive components found in Curcuma species, including turmeric (Curcuma longa L.). Curcumin is a polyphenol that is used as an antioxidant. Various analytical methods have been developed for the detection of curcumin, each with its advantages and limitations. Selection of an appropriate analytical method is crucial for obtaining accurate results. Although critical reviews on the chemical, biological, and pharmacological properties of curcumin are widely available, reviews specifically focusing on the different analytical methods for curcumin are limited. This review article aims to provide an overview of several analytical methods for the determination of curcumin. This is expected to encourage readers to choose a suitable analytical method for their specific needs. The articles used in this review were sourced from international English-language publications obtained from Science Direct, PubMed, and Google Scholar. The search was performed using keywords such as "Instrumental analysis of curcumin" and "Analytical techniques for curcumin analysis." The results reveal that spectrophotometric methods are simple techniques used to estimate curcumin content; however, their utility is limited to cases where the concentration of each curcuminoid is not a critical quality parameter. Accurate quantification and detection of trace amounts of curcuminoids and metabolites require the use of chromatographic separation methods combined with mass spectrometry detection (LC-MS/MS) because of their high accuracy, reproducibility, and sensitivity with low limits of detection (LOD) and lower limits of quantification (LLOQ). Keywords: Analytical methods, Curcumin, Determination

show abstract

Cited by 10 publications

References 25 publications

Review: bioavailability and efficacy of ‘free’ curcuminoids from curcumagalactomannoside (CGM) curcumin formulation

Review: bioavailability and efficacy of ‘free’ curcuminoids from curcumagalactomannoside (CGM) curcumin formulation

Study on the reduction of Tartary buckwheat allergenicity during Pediococcus pentosaceus fermentation by HPLC-MS/MS analysis

Comparison of Analysis Methods for Curcumin Determination: A Literature Review

Contact Info

Product

Resources

About