Development of a Larvicidal Nanoemulsion with Pterodon emarginatus Vogel Oil

Oliveira, Anna Eliza Maciel de Faria Mota; Duarte, Jonatas Lobato; Amado, Jesús Rafael Rodríguez; Cruz, Rodrigo Alves Soares; Rocha, Clarice Flexa da; Souto, Raimundo Nonato Picanço; Ferreira, Ricardo M. A.; Santos, Karen Cristine Gonçalves Dos; Conceição, Edemilson Cardoso da; Oliveira, Leandra A. R. de; Kelecom, Alphonse; Fernandes, Caio P.; Carvalho, José Carlos Tavares

doi:10.1371/journal.pone.0145835

Cited by 62 publications

(39 citation statements)

References 60 publications

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“…These results are similar to those found for other plant oils such as Copaíba oil of the genus Copaifera [50] and the oil extracted from fruit of the species Litsea cubeba [51]. Similar results were observed in Swiss mice treated with a nanoemulsion made from the oil of the Sucupira tree Pterodon emarginatus Vogel [52].…”

Section: Journal Of Nanomaterialssupporting

confidence: 88%

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Milhomem-Paixão

Fascineli

Muehlmann

et al. 2017

Journal of Nanomaterials

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Andiroba oil (AO) is obtained from an Amazonian plant and is used in traditional medicine. We carried out a comparative study to test the cytotoxicity, genotoxicity, and hematotoxicity of the oil and its nanoemulsion (AN) in vitro (fibroblasts, lineage NIH/3T3) and in vivo (Swiss mice). The AN was characterized by DLS/Zeta, and its stability was investigated for 120 days. The biological activity of AN was assessed in vitro by MTT test and cell morphology analyses and in vivo by micronucleus, comet, and hematotoxicity tests. The AN presented a hydrodynamic diameter (Hd) of 142.5 ± 3.0 and PDI of 0.272 ± 0.007 and good stability at room temperature. The MTT test evidenced the cytotoxicity of AO and of AN only at their highest concentrations, but AN showed lower cytotoxicity than AO. A lower cytotoxicity of AN, when compared to AO, is in fact an interesting data suggesting that during therapeutic application there will be a lower impact in the cell viability of healthy cells. Cytotoxicity, genotoxicity, and hematotoxicity were not observed in vivo. These tests on the biological and toxicological effects of andiroba oil and nanostructured oil are still initial ones but will give a direction to future application in cosmetics and/or the development of new phytotherapics.

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Section: Journal Of Nanomaterialssupporting

confidence: 88%

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Milhomem-Paixão

Fascineli

Muehlmann

et al. 2017

Journal of Nanomaterials

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“…The Sucupira oil has also been studied as their larvicidal activity by Oliveira et al (2016). Pterodon emarginatus Vogel is a Brazilian species that belongs to the family Fabaceae, popularly known as Sucupira or Sucupira branca.…”

Section: Pitmentioning

confidence: 99%

“…The repellant effect of the NE (4.7 hours) could be attributed to a major difference in oil droplet size. Therefore, the small droplet size of NE prepared with HPH would play an important role on their efficacy.The Sucupira oil has also been studied as their larvicidal activity by Oliveira et al (2016). Pterodon emarginatus Vogel is a Brazilian species that belongs to the family Fabaceae, popularly known as Sucupira or Sucupira branca.…”

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confidence: 99%

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation in nanoemulsions is considered a promising strategy to facilitate the applicability of these natural compounds and to potentiate the actions. These formulations offer several advantages for topical and systemic delivery of cosmetic and pharmaceutical agents including controlled droplet size, protection of the vegetable oil to photo, thermal and volatilization instability and ability to dissolve and stabilize lipophilic drugs. For these reasons, the aim of this review is to report on some characteristics, preparation methods, applications and especially analyze recent research available in the literature concerning the use of vegetable oils with therapeutic characteristics as lipid core in nanoemulsions, specially from Brazilian flora, such as babassu (Orbignya oleifera), aroeira (Schinus molle L.), andiroba (Carapa guaianiensis), casca-de-anta (Drimys brasiliensis Miers), sucupira (Pterodon emarginatus Vogel) and carqueja doce (Stenachaenium megapotamicum) oils.Uniterms: Plant oils/nanoemulsions/preparation. Plant oils/biological applications. INTRODUCTIONThe use of submicrometric colloidal nanocarriers such as nanoparticles (NP) lipid and polymeric, nanoemulsions (NE), microemulsions (ME), liposomes, and polymeric micelles is considered a promising system in the pharmaceutical field, because they have numerous advantages over traditional formulations such as: sustained release of the active element; solubilization of lipophilic molecules; use for different routes of administration; protection from chemical and enzymatic degradation of labile molecules; reduction of vegetable oils (VO) volatilization, side effects and dose (Mäder, Mehnert, 2005;Mehnert, Mäder, 2001;Gref, Couvreour, 2006;Couvreur, Vauthier, 2006; Panyam, Labhasetwar, 2003;Soppimath et al., 2001;Ai et al., 2011; Contri et al., 2012;Contri et al., 2014;Dimer et al., 2014;Severino et al., 2015;Frank et al., 2015;Asbahani et al., 2015). However, all systems differ thermodynamic stability, structure, chemical composition, efficiency encapsulation and types of application (Mäder, Mehnert, 2005;Ai et al., 2011).The development of suitable nanocarriers for pharmaceutical or cosmetic application requires the adequate selection of their adjuvants such as polymers for nanocapsules (NC), surfactants, and oils (Schaffazick et al., 2003;Alvarez-Román et al., 2001;Bouchemal et al., 2004;Friedrich et al., 2008). Recently, special attention has been given to the type of oily phase used as the core in the preparation of NE. VO has been preferred not only due to the concept that it is safe and biocompatible, but mainly because of the diversity of benefits, and the complex composition of fatty acids can exercise under the skin, protecting it against dehydration, solar radiation, inflammation, insect attack, microorganisms, and viruses (Tadros, Kessell, 2004;Bloise, 2003;Oyedeji, Okeke, 2010;Bakkali et. al., 2008;Harris, 2002; Contri et al, ...

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“…Na medicina, o óleo essencial de P. emarginatus é fortemente aromático sendo usado no combate ao reumatismo, diabetes e doenças respiratórias (bronquite e amigdalite) (LEONHARDT et al, 2010;HOSCHEID;CARDOSO, 2015). Além dessas várias atividades biológicas, o óleo de sucupira-branca apresenta propriedade larvicida contra o mosquito da dengue (Aedes aegypti) (OLIVEIRA et al, 2016). A sucupira-branca é planta amplamente incorporada à etnobotânica brasileira, sendo geralmente preservada pela agricultura e pecuária familiar, podendo ser encontrada como elemento de sombreamento em pastos e em roças artesanais.…”

Section: Introductionunclassified

Propagação in vitro de sucupira branca (Pterodon emarginatus Vogel): uma espécie florestal nativa

Canatto¹,

Albino²,

Cordeiro³

2016

ANAP

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Development of a Larvicidal Nanoemulsion with Pterodon emarginatus Vogel Oil

Cited by 62 publications

References 60 publications

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Propagação in vitro de sucupira branca (Pterodon emarginatus Vogel): uma espécie florestal nativa

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