Development of a Kinetic Spectrophotometry Method for the Determination of Ciclopirox Olamine in Pharmaceutical Sample

Abstract

SA simple and sensitive kinetic spectrophotometric method was developed for the determination of ciclopirox olamine in pharmaceutical formulations (cream). The method is based on the oxidation of ciclopirox olamine with KMnO 4 in alkaline medium to form K 2 MnO 4 , a bluish green color compound, at ionic strength controlled and room temperature. The reaction is monitored measuring the rate of change of absorbance at 610 nm. The absorbance-concentration plot corresponding to synthetic pharmaceutical samples (cream) was rectilinear, over the range of 0.32 -10.0 µg mL -1 , with detection and quantification limits of 0.095 µg mL -1 and 0.32 µg mL -1 , respectively. Different experimental parameters affecting the development and stability of the reaction product were carefully studied via factorial screening and optimized by univariate method. The determination of ciclopirox olamine by the fixed time method is feasible and more advantageous with the calibration equation obtained at 30 min. The proposed method was validated for the application of the determination of the drug in pharmaceutical sample (cream).

Sensitive Kinetic Spectrophotometric Method for the Determination of Diphenhydramine in Real Samples

“…Some of the reported methods have limitations such as time-consuming procedures, interference from substances and/or relatively high cost of instrumentation. Kinetic spectrophotometry methods have comparable levels of accuracy and sensitivity to the methods above mentioned and have been used in the quantification of different pharmaceutical analytes in different matrices [39][40][41][42][43]. In these methods, the absorbance variation in the time is measured under nonequilibrium conditions.…”

Development and Validation of Visible Spectrophotometric Method for Estimation of Eltrombopag Olamine in Bulk and Tablet Dosage Form

“…The development of a basic, precise, reliable, and repetitive Visible Spectrophoto-metric method for the quantification of Eltrombopag Olamine in bulk and in tablet dosage form is described in the current work. According to ICH Guidelines, the developed approach was validated [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”