Development of a Job-Exposure Matrix for Ultrafine Particle Exposure: The MatPUF JEM

Audignon-Durand, Sabyne; Gramond, Céline; Ducamp, Stéphane; Manangama, Guyguy; Garrigou, Alain; Delva, Fleur; Brochard, Patrick; Lacourt, Aude

doi:10.1093/annweh/wxaa126

Cited by 15 publications

(12 citation statements)

References 40 publications

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“…However, given the current state of knowledge on occupational exposure levels, which is patchy and based on heterogeneous methods, we have chosen to limit the assessment to probability [ 28 ]. The nanoparticle assessment used in this study was possible thanks to the knowledge acquired in the framework of the development of the job-exposure matrix MatPUF [ 29 ]. Such a job-exposure matrix might be useful to improve the quality and the accuracy of nanoparticle exposure assessment during a full occupational career, providing for each job chronological exposure data and main chemical families of released nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases

Forest

Pourchez

Pélissier

et al. 2021

Toxics

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The biomonitoring of nanoparticles in patients’ broncho-alveolar lavages (BAL) could allow getting insights into the role of inhaled biopersistent nanoparticles in the etiology/development of some respiratory diseases. Our objective was to investigate the relationship between the biomonitoring of nanoparticles in BAL, interstitial lung diseases and occupational exposure to these particles released unintentionally. We analyzed data from a cohort of 100 patients suffering from lung diseases (NanoPI clinical trial, ClinicalTrials.gov Identifier: NCT02549248) and observed that most of the patients showed a high probability of exposure to airborne unintentionally released nanoparticles (>50%), suggesting a potential role of inhaled nanoparticles in lung physiopathology. Depending on the respiratory disease, the amount of patients likely exposed to unintentionally released nanoparticles was variable (e.g., from 88% for idiopathic pulmonary fibrosis to 54% for sarcoidosis). These findings are consistent with the previously performed mineralogical analyses of BAL samples that suggested (i) a role of titanium nanoparticles in idiopathic pulmonary fibrosis and (ii) a contribution of silica submicron particles to sarcoidosis. Further investigations are necessary to draw firm conclusions but these first results strengthen the array of presumptions on the contribution of some inhaled particles (from nano to submicron size) to some idiopathic lung diseases.

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Section: Discussionmentioning

confidence: 99%

Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases

Forest

Pourchez

Pélissier

et al. 2021

Toxics

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show abstract

“…It does not consider their exposure on an individual level, which could lead to a differential misclassification and an underestimation of the association [ 34 ]. Third, the design of the current version of MatPUF [ 19 ] does not provide a metric for the level of intensity of exposure. Therefore, it was not possible to examine the effects associated with high- or low-intensity exposure.…”

Section: Discussionmentioning

confidence: 99%

“…To assess the occupational exposure to UFPs, we used the MatPUF job-exposure matrix (JEM), which is specific to UFPs. The methodology of its construction has been previously described by Audignon, et al [ 19 ]. Briefly, work processes that lead to an exposure to UFPs were identified thanks to a comprehensive literature review combined with the judgement of an expert panel that covered various domains (toxicology, industrial hygiene, physics, atmospheric chemistry and epidemiology).…”

Section: Methodsmentioning

confidence: 99%

Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases

Pasquiou

Pelluard

Manangama

et al. 2021

IJERPH

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Ultrafine particles (UFPs) are particles smaller than 100 nanometers that are produced unintentionally during human activities or natural phenomena. They have a higher biological reactivity than bigger particles and can reach the placenta after maternal exposure. One study has shown an association between maternal occupational exposure to UFPs and fetal growth restriction. Yet few studies have focused on the effects of UFP exposure on placental histopathological lesions. The aim of this study was to investigate the association between maternal occupational exposure to UFPs and histopathological lesions of their placenta. The analyses were based on data from the ARTEMIS Center. A job-exposure matrix was used to assess occupational exposure to UFPs. The histopathological placental exam was performed by two pathologists who were blinded to the exposure of each subject. The examination was conducted in accordance with the recommendations of the Amsterdam consensus. The study sample included 130 placentas (30 exposed, 100 unexposed). Maternal occupational exposure to UFPs during pregnancy is significantly associated with placental hypoplasia (the phenomenon affected 61% of the exposed patients and 34% of the unexposed ones, p < 0.01). Further research is needed to explain its pathophysiological mechanisms.

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“…Still, there is limited knowledge about the levels and composition of diesel exposures in modern underground mines today. This is needed, for example, to create improved job-exposure matrices in epidemiological studies to allow future risk assessments (Plato et al 2020 ; Audignon-Durand et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Underground emissions and miners’ personal exposure to diesel and renewable diesel exhaust in a Swedish iron ore mine

Gren

Krais

Assarsson

et al. 2022

Int Arch Occup Environ Health

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Purpose Underground diesel exhaust exposure is an occupational health risk. It is not known how recent intensified emission legislation and use of renewable fuels have reduced or altered occupational exposures. We characterized these effects on multipollutant personal exposure to diesel exhaust and underground ambient air concentrations in an underground iron ore mine. Methods Full-shift personal sampling (12 workers) of elemental carbon (EC), nitrogen dioxide (NO2), polycyclic aromatic hydrocarbons (PAHs), and equivalent black carbon (eBC) was performed. The study used and validated eBC as an online proxy for occupational exposure to EC. Ambient air sampling of these pollutants and particle number size distribution and concentration were performed in the vicinity of the workers. Urine samples (27 workers) were collected after 8 h exposure and analyzed for PAH metabolites and effect biomarkers (8-oxodG for DNA oxidative damage, 4-HNE-MA for lipid peroxidation, 3-HPMA for acrolein). Results The personal exposures (geometric mean; GM) of the participating miners were 7 µg EC m−3 and 153 µg NO2 m−3, which are below the EU occupational exposure limits. However, exposures up to 94 µg EC m−3 and 1200 µg NO2 m−3 were observed. There was a tendency that the operators of vehicles complying with sharpened emission legislation had lower exposure of EC. eBC and NO2 correlated with EC, R = 0.94 and R = 0.66, respectively. No correlation was found between EC and the sum of 16 priority PAHs (GM 1790 ng m−3). Ratios between personal exposures and ambient concentrations were similar and close to 1 for EC and NO2, but significantly higher for PAHs. Semi-volatile PAHs may not be effectively reduced by the aftertreatment systems, and ambient area sampling did not predict the personal airborne PAHs exposure well, neither did the slightly elevated concentration of urinary PAH metabolites correlate with airborne PAH exposure. Conclusion Miners’ exposures to EC and NO2 were lower than those in older studies indicating the effect of sharpened emission legislation and new technologies. Using modern vehicles with diesel particulate filter (DPF) may have contributed to the lower ambient underground PM concentration and exposures. The semi-volatile behavior of the PAHs might have led to inefficient removal in the engines aftertreatment systems and delayed removal by the workplace ventilation system due to partitioning to indoor surfaces. The results indicate that secondary emissions can be an important source of gaseous PAH exposure in the mine.

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Development of a Job-Exposure Matrix for Ultrafine Particle Exposure: The MatPUF JEM

Cited by 15 publications

References 40 publications

Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases

Relationship between Occupational Exposure to Airborne Nanoparticles, Nanoparticle Lung Burden and Lung Diseases

Occupational Exposure to Ultrafine Particles and Placental Histopathological Lesions: A Retrospective Study about 130 Cases

Underground emissions and miners’ personal exposure to diesel and renewable diesel exhaust in a Swedish iron ore mine

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