Development of a high-strength Zn-Mn-Mg alloy for ligament reconstruction fixation

Sun, Jian; Zhang, Xin; Shi, Zhang; Gao, Xuan; Li, Huiyan; Zhao, Fengyuan; Wang, Jianquan; Wang, Luning

doi:10.1016/j.actbio.2020.10.032

Cited by 52 publications

(55 citation statements)

References 57 publications

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“…Results from assessing the risk of bias and quality of evidence Among the seven included animal studies, only one randomized controlled trial was included (Diekmann et al, 2016) but did not explain the specific random grouping and whether covert grouping was implemented. Only two studies reported the equilibrium of baseline characteristics such as age, sex, and body weight of animals (Mao et al, 2021;Sun et al, 2021).…”

Section: Basic Information Of Studiesmentioning

confidence: 99%

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The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies

Shang

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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Objective: The actual efficacy of magnesium and its alloy in anterior cruciate ligament reconstruction (ACLR) was systematically evaluated to reduce the risk of translation from animal experiments to the clinic.Methods: Databases of PubMed, Ovid-Embase, Web of Science, CNKI, Wanfang, VIP, and CBM were searched for literature in July 2021. Screening of search results, data extraction, and literature quality evaluation were undertaken independently by two reviewers.Results and discussion: Seven articles were selected for the meta-analysis. The results showed that the mechanical properties of the femoral-tendon graft–tibia complex fixed with magnesium and its alloys were comparable to those fixed with titanium and its alloys, and magnesium and its alloys were superior to titanium and its alloys in promoting new bone formation. In addition, the unique biodegradability made magnesium and its alloys an orthopedic implant with significant therapeutic potential. However, whether the degradation rate of magnesium and its alloy can match the rate of bone-tendon integration, and whether the bioconjugation of bone-tendon after degradation can meet the exercise load still needs to be explored in further detail. Simultaneously, it is necessary for future research to improve and standardize experimental design, result measurement, etc., so as to minimize the risk of transforming animal experimental results into clinical practice.

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Section: Basic Information Of Studiesmentioning

confidence: 99%

“…Only three studies reported randomized placement of animals during the experiment (Cheng et al, 2016b;Diekmann et al, 2016;Sun et al, 2021). Based on limited information provided by the included studies, all studies were unable to determine whether or not to blind animal breeders and/or researchers.…”

Section: Basic Information Of Studiesmentioning

confidence: 99%

The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies

Shang

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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“…Liu reported that the corrosion rate of Zn-Mn alloys was significantly higher than that of Zn-Mg alloys [ 12 ]. Recently, researchers found that adding magnesium (Mg) and manganese (Mn) alloy elements to pure zinc greatly improved the mechanical properties of the alloy and also increased the corrosion rate [ 13 , 14 ]. Alloying can accelerate the corrosion rate of Zn alloys, but it is still lower than the ideal corrosion rate (0.1–0.5 mm/a).…”

Section: Introductionmentioning

confidence: 99%

Surface Treatment of Zn-Mn-Mg Alloys by Micro-Arc Oxidation in Silicate-Based Solutions with Different NaF Concentrations

Sun

et al. 2021

Materials

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Newly developed Zn-Mn-Mg alloys can be invoked as biomedical materials because of their excellent mechanical properties. However, the corrosion behavior of Zn-Mn-Mg alloys was still lacking in research. It had grown to be a hot research topic to improve the corrosion behavior of Zn alloys by surface treatment to meet the application of degradable Zn alloys in biomedical applications. Micro arc oxidation (MAO) is a simple and effective method to improve the corrosion behavior of the alloy. MAO coatings were successfully prepared on the surface of Zn-Mn-Mg alloys by MAO in silicate-based solutions with different NaF concentrations. The microstructure and phase composition of MAO coatings prepared on Zn-Mn-Mg alloys with different NaF concentrations in the electrolyte was examined by a scanning electron microscope and X-ray diffraction. The results showed that the MAO coatings are porous and mainly composed of ZnO. With the increasing NaF concentration in the electrolyte, the average thickness increases. The distribution of the micro/nanopores was uniform, and the pore size ranged from the submicron scale to several micrometers after MAO treatment in the electrolyte containing different concentrations of NaF. Potential dynamic polarization curves and electrochemical impedance spectroscopy were employed to assess the corrosion behavior of MAO coatings in Hank’s solution. The highest corrosion rate can be achieved after MAO treatment, with an electrolyte concentration of 1.5 g/L NaF in Hank’s solution. These results indicated that MAO coating can accelerate the corrosion resistance of a Zn-Mn-Mg alloy.

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“…A total of 2,176 references (1,908 English and 268 Chinese publications) were searched through databases. After excluding duplicates and those not meeting the inclusion criteria, seven papers (Cheng et al, 2016b;Cheng et al, 2016c;Diekmann et al, 2016;Wang et al, 2017a;Wang et al, 2017b;Mao et al, 2021;Sun et al, 2021) about graft during ACL reconstruction with magnesium and its alloys were included in our systematic review, and all were in English literature. The flowchart of the literature screening is shown in Figure 1.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…Of the seven animal studies included, only one study (Diekmann et al, 2016) was a randomized controlled trial, and the other six studies (Cheng et al, 2016b;Cheng et al, 2016c;Wang et al, 2017a;Wang et al, 2017b;Mao et al, 2021;Sun et al, 2021) were all controlled trials. All experimental animals were New Zealand white rabbits.…”

Section: Basic Information Of Studiesmentioning

confidence: 99%

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Development of a high-strength Zn-Mn-Mg alloy for ligament reconstruction fixation

Cited by 52 publications

References 57 publications

The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies

The Role of Biodegradable Magnesium and Its Alloys in Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis Based on Animal Studies

Surface Treatment of Zn-Mn-Mg Alloys by Micro-Arc Oxidation in Silicate-Based Solutions with Different NaF Concentrations

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