Development of a high resolution PET

Yamashita, T.; Uchida, Hiroshi; Okada, Hiroyuki; Kurono, Takehiro; Takemori, Tamiki; Watanabe, M.; Shimizu, Katsuji; Yoshikawa, Etsuji; Ohmura, T.; Satoh, N.; Tanaka, Eiichi; Nohara, Norimasa; Tomitani, Takehiro; Yamamoto, Mikio; Murayama, Hideo; Endo, Masahiro

doi:10.1109/23.106683

Cited by 37 publications

(14 citation statements)

References 21 publications

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“…Following a bolus intravenous injection of a 450-MBq dose of [ 11 C]WIN 35,428, a sequence of 38 PET (SHR2400 PET scanner [21], Hamamatsu Photonics K.K., Hamamatsu, Japan) scans was obtained over 90 minutes. Arterial blood samples were drawn at intervals of 10 seconds to 15 minutes after the tracer injection.…”

Section: Pet Studymentioning

confidence: 99%

Methamphetamine-Related Psychiatric Symptoms and Reduced Brain Dopamine Transporters Studied With PET

Sekine

Iyo²,

Ouchi³

et al. 2001

AJP

367

255

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These findings suggest that longer use of methamphetamine may cause more severe psychiatric symptoms and greater reduction of dopamine transporter density in the brain. They also show that the dopamine transporter reduction may be long-lasting, even if methamphetamine use ceases. Further, persistent psychiatric symptoms in methamphetamine users, including psychotic symptoms, may be attributable to the reduction of dopamine transporter density.

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Section: Pet Studymentioning

confidence: 99%

Methamphetamine-Related Psychiatric Symptoms and Reduced Brain Dopamine Transporters Studied With PET

Sekine

Iyo²,

Ouchi³

et al. 2001

AJP

367

255

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“…These GSO cells were arranged into 4 × 3 matrix and formed a two-dimensional array of the GSO block and were optically coupled to a one-dimensionally arranged quad-PMT (R3309, Hamamatsu Photonics, Hamamatsu, Japan). The PMT was originally developed and used for positron emission tomography (PET) systems [10] and has four channels in which the single size is 5 mm × 10 mm. The PMT was optically coupled to the GSO block from the side.…”

Section: Principle Of Operationmentioning

confidence: 99%

Development of a tweezers-type coincidence imaging detector

et al. 2008

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“…(1). Illustration of the significant improvement in clinical 18 F-FDG brain PET image quality and spatial resolution resulting from the improvement in scanner performance for each generation during the last three decades (Reproduced from CTI Molecular Imaging web site). designed for clinical whole-body applications to others designed specifically for very high-resolution brain research applications.…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, most of the first human PET prototypes were developed specifically for functional brain imaging including the PET III developed by Phelps and colleagues [5,6]; PC-II [7], Positome II [8], as well as PETTV [9] and PETTVI [10] tomographs built in the late 70s using sodium iodide (NaI(Tl)) and Cesium Fluoride (CsF) crystals, respectively. Many other designs have also been developed in the early 80s including the Positologica [11], HEADTOME [12], *Address correspondence to this author at Geneva University Hospital, Division of Nuclear Medicine, CH-1211 Geneva, Switzerland; Tel: +41 22 372 7258; Fax: +41 22 372 7169; E-mail: habib.zaidi@hcuge.ch Neuro-PET [13], Scanditronix PC384-7b [14] and PC2048-15B [15], NeuroECAT [16,17], the Hamamatsu SHR 1200/2400 tomographs [18] and the CTI/Siemens ECAT 953B [19], considered as state of the art technology in the early 1990s.…”

Section: Introductionmentioning

confidence: 99%

The New Challenges of Brain PET Imaging Technology

Zaidi¹,

Montandon

2006

CMIR

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During the last two decades, functional brain imaging using positron emission tomography (PET) has advanced elegantly, and steadily gained importance in the clinical and research arenas. Significant progress has been made by different scanner manufacturers and research groups in the design of dedicated high-resolution three-dimensional (3-D) PET units; however, emerging clinical and research applications of functional brain imaging promise even greater levels of accuracy and precision and therefore, impose more constraints with respect to the intrinsic performance of the PET tomograph. Continuous efforts to integrate recent research findings for the design of different geometries and various detector/readout technologies of PET scanners have become the goal of both the academic community and nuclear medicine industry. As PET has become integrated into clinical practice, several design trends have developed; with systems now available with a spectrum of features, from those designed for "low cost" clinical applications to others designed specifically for very high-resolution research applications. There is also a continual upward revision and refinement in both hardware and software components for all of these systems.Software-and hardware-based correlation between anatomical (x-ray CT, MRI) and physiological (PET) information is a promising research field and now offers unique capabilities for the medical imaging community and biomedical researchers. One of the main advantages of dual-modality PET/CT imaging is that PET data are intrinsically aligned to anatomical information from the x-ray CT without the use of external markers or internal landmarks, thus providing a reliable estimate of the attenuation map to be used for attenuation and scatter correction purposes. On the other hand, combining PET with MRI technology is scientifically more challenging owing to the strong magnetic fields. Nevertheless, significant progress has been made resulting in the design of a prototype small animal PET scanner coupled to three multichannel photomultipliers via optical fibers, so that the PET detector can be operated within a conventional MR system. Thus, many different design paths have been and continue to be pursued in both academic and corporate settings, that offer different trade-offs in terms of their performance. It still is uncertain which designs will be incorporated into future clinical and research systems, but it is certain that technological advances will continue and will enable new quantitative capabilities in brain PET imaging. This paper briefly summarizes state of the art developments in dedicated brain PET instrumentation. Future prospects will also be discussed.

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Development of a high resolution PET

Cited by 37 publications

References 21 publications

Methamphetamine-Related Psychiatric Symptoms and Reduced Brain Dopamine Transporters Studied With PET

Methamphetamine-Related Psychiatric Symptoms and Reduced Brain Dopamine Transporters Studied With PET

Development of a tweezers-type coincidence imaging detector

The New Challenges of Brain PET Imaging Technology

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