Development of a generic assay for the determination of total trihydroxybenzoate derivatives based on gold-luminol chemiluminescence

Giokas, Dimosthenis L.; Christodouleas, Dionysios C.; Vlachou, Ioanna; Vlessidis, Athanasios G.; Calokerinos, Antony C.

doi:10.1016/j.aca.2012.12.025

Cited by 22 publications

(14 citation statements)

References 51 publications

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“…A selective and specific assay was developed by Giokas et al [88] for the determination of an important class of phenolic compounds named trihydroxybenzoates, based on the fact that they enhance CL between gold ions and luminol. Recently, Hong et al [89] described a chemiluminescent cholesterol sensor with good selectivity and enhanced sensitivity based on the peroxidase-like activity of cupric oxide nanoparticles.…”

Section: Biosensorsmentioning

confidence: 99%

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Khan

Idrees

Moxley

et al. 2014

Appl Biochem Biotechnol

232

181

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Chemiluminescence (CL) is an important method for quantification and analysis of various macromolecules. A wide range of CL agents such as luminol, hydrogen peroxide, fluorescein, dioxetanes and derivatives of oxalate, and acridinium dyes are used according to their biological specificity and utility. This review describes the application of luminol chemiluminescence (LCL) in forensic, biomedical, and clinical sciences. LCL is a very useful detection method due to its selectivity, simplicity, low cost, and high sensitivity. LCL has a dynamic range of applications, including quantification and detection of macro and micromolecules such as proteins, carbohydrates, DNA, and RNA. Luminol-based methods are used in environmental monitoring as biosensors, in the pharmaceutical industry for cellular localization and as biological tracers, and in reporter gene-based assays and several other immunoassays. Here, we also provide information about different compounds that may enhance or inhibit the LCL along with the effect of pH and concentration on LCL. This review covers most of the significant information related to the applications of luminol in different fields.

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Section: Biosensorsmentioning

confidence: 99%

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Khan

Idrees

Moxley

et al. 2014

Appl Biochem Biotechnol

232

181

View full text Add to dashboard Cite

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“…[18][19][20] Despite originating from the same molecule, as light difference in the emissions pectra is observed upon operating in either aprotic or protic solvents. [18] Ab lueshift of the maximum chemiluminescence wavelength is observed in protic environments with respect to aprotics olutions, from l = 485 [18] /502 [19,20] /510 [21] nm in DMSO to 424 [6,18,21] / 431 [19,20] nm in water.S uch ad ifferenceh as been postulated experimentally to be related to the presence of two distinct excited-state emitters in DMSO and water,with and without in-tramolecular hydrogen transfer from the amino group to the nearbyo xygen atom, respectively. [18] In general, the chemiluminescenceo fLH 2 is not ap rocess with high probability;i ts quantum yield is in the order of 10 À2 .…”

Section: Introductionmentioning

confidence: 98%

“…[1] One of the most important and popularc hemiluminescent systemsi st he luminol molecule (5-amino-2,3-dihydrophthalazine-1,4-dione, LH 2 ), whichi s widely used in forensic science to detect traces of blood, since it is catalyzed by iron of the hemoglobin protein. [1,2] First discoveredi n1 928 by Albrecht, [3] the chemiluminescence of LH 2 has since been the topic of many fundamentals tudies and the development of commercial analytical assay kits [4][5][6][7][8][9] and challenging therapeutic procedures to treat cancers in deep tissues. [10][11][12][13][14] It is worth mentioning in this last context, for example, investment from hospitals and research groups to find noninvasive methodst ot reat inaccessible tumors, for example, the glioblastoma multiformeb rain tumor,b ym eans of mitochondria-targeting LH 2 systems.…”

Section: Introductionmentioning

confidence: 99%

Molecular Basis of the Chemiluminescence Mechanism of Luminol

Giussani

Farahani

Martínez‐Muñoz

et al. 2019

Chemistry A European J

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Light emission from luminol is probably one of the most popular chemiluminescence reactions due to its use in forensic science, and has recently displayed promising applications for the treatment of cancer in deep tissues. The mechanism is, however, very complex and distinct possibilities have been proposed. By efficiently combining DFT and CASPT2 methodologies, the chemiluminescence mechanism has been studied in three steps: 1) luminol oxygenation to generate the chemiluminophore, 2) a chemiexcitation step, and 3) generation of the light emitter. The findings demonstrate that the luminol double‐deprotonated dianion activates molecular oxygen, diazaquinone is not formed, and the chemiluminophore is formed through the concerted addition of oxygen and concerted elimination of nitrogen. The peroxide bond, in comparison to other isoelectronic chemical functionalities (−NH−NH−, −N−−N−−, and −S−S−), is found to have the best chemiexcitation efficiency, which allows the oxygenation requirement to be rationalized and establishes general design principles for the chemiluminescence efficiency. Electron transfer from the aniline ring to the OO bond promotes the excitation process to create an excited state that is not the chemiluminescent species. To produce the light emitter, proton transfer between the amino and carbonyl groups must occur; this requires highly localized vibrational energy during chemiexcitation.

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“…The use of these analytical procedures has been described for the direct determination of polyphenol content in food samples (Mannino et al 1998;Kanwal et al 2009;Nalewajko-Sieliwoniuk et al 2010;Araujo et al 2011;Giokas et al 2013;Andrade et al 2014). These procedures employed mainly chemiluminescence for the analyte determination (Kanwal et al 2009;Nalewajko-Sieliwoniuk et al 2010;Araujo et al 2011;Giokas et al 2013;Andrade et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Determination of Polyphenol Content by Formation of Unstable Compound Using a Mini-Pump Multicommutation System

Assis

Andrade

Montenegro³

et al. 2016

Food Anal. Methods

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This article describes a multicommuted flow procedure for photometric determination of the polyphenol content in wines and teas, exploiting the formation of unstable intermediate products, by the reaction of sodium hypochloride with gallic acid. Because the lifetime of the formed compound is very short, a special flow cell was designed in order to enable mixing of sample and reagent solution within the flow cell, thus allowing signal monitoring, while compound formation proceeded. The flow system manifold comprised three solenoid mini-pumps to propel sample, reagent solution, and carrier fluid. The photometer consisted of a photodiode and a light emitting diode (LED) with maximum emission at 490 nm. Under the selected operational conditions, useful features including a linear response ranging from 62 to 1000 mg L −1 gallic acid solution (R = 0.9987), a detection limit of 21 mg L −1 gallic acid, a sampling rate of 120 determinations per hour, a relative standard deviation of 1.9 % (n = 20) for a typical solution containing 400 mg L −1 gallic acid, and a waste generation of 1.0 mL per determination were also achieved. Medium recovery values of 96.2 ± 10.4 and 101.9 ± 7.3 % for wines and teas, respectively, were achieved.

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Development of a generic assay for the determination of total trihydroxybenzoate derivatives based on gold-luminol chemiluminescence

Cited by 22 publications

References 51 publications

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

Molecular Basis of the Chemiluminescence Mechanism of Luminol

Determination of Polyphenol Content by Formation of Unstable Compound Using a Mini-Pump Multicommutation System

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