Development of a Drug Delivery System Based on Chitosan Nanoparticles for Oral Administration of Interferon-α

Cánepa, Camila; Imperiale, Julieta Celeste; Berini, Carolina Andrea; Lewicki, Marianela; Sosnik, Alejandro; Biglione, Mirna

doi:10.1021/acs.biomac.7b00959

Cited by 65 publications

(44 citation statements)

References 31 publications

(47 reference statements)

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“…This could lead to a reduced stability and to the loss of other important properties, e.g. the antimicrobial character …”

Section: Stability Of Ig‐obtained Nanoparticles/microparticlesmentioning

confidence: 99%

“…Other encapsulation techniques, such as electrospraying, are known to obtain a narrow particle size distribution; this is not always the case with IG. Polydispersion indices (PDI) are usually higher than 0.1, reaching values up to 0.5 . This indicates a heterogeneity in particle size that not only could affect the quantity of the drug loaded but could also limit the interaction of the formulation with biological structures.…”

Section: Disadvantagesmentioning

confidence: 99%

“…More precise methods to estimate the quantity of proteins under these circumstances are enzyme linked immunosorbent assay and HPLC. Both techniques are also useful to measure free quantities of other types (not protein) of active principal and have been used to calculate the encapsulation efficiency of nanoparticulate/microparticulate systems obtained by IG . In terms of EE, better or worse values will finally depend on the biological effect of the formulation and its behavior in comparison to the unencapsulated drug.…”

Section: Characterizing the Nanoparticles/microparticlesmentioning

confidence: 99%

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Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Pedroso‐Santana

Fleitas‐Salazar

2020

Polymer International

150

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The encapsulation of drugs inside polymeric nanoparticles/microparticles is a strategy currently employed in the search for new and more effective therapies. The use of biocompatible and biodegradable polymers gives several advantages to these formulations. Protection of the active principals against the action of environmental and physiological agents, the reduced number of doses and a subsequent decrease in drug-related adverse effects, and increased bioavailability are some of these advantages. Several methods and materials are now used to synthesize nanoparticles/microparticles for biomedical applications, from carbon-derived structures to metallic and lipid particles. However, among the methods using polymers, ionotropic gelation is one of the more affordable and easier procedures to perform in daily laboratory work. In this mini-review, we address relevant characteristics of ionotropic gelation, beginning with basic aspects of the technique, which reagents and conditions are commonly used, the factors affecting the stability of the formulation, the advantages and disadvantages of the method and some principal characterization techniques for the nanoparticulate/microparticulate formulation. Finally, we conclude with a few important considerations.

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“…This could lead to a reduced stability and to the loss of other important properties, e.g. the antimicrobial character …”

Section: Stability Of Ig‐obtained Nanoparticles/microparticlesmentioning

confidence: 99%

Section: Disadvantagesmentioning

confidence: 99%

Section: Characterizing the Nanoparticles/microparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Pedroso‐Santana

Fleitas‐Salazar

2020

Polymer International

150

View full text Add to dashboard Cite

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“…The study was aimed to assess the possible application of this system for bone tissue engineering. Similarly, Biglione et.al., described the design and full characterization of a novel CS based nano carrier for the oral delivery of IFNα‐2b protein that is used to treat different types of cancer and viral infections, aiming to replace its parenteral administration.…”

Section: Chitosan and Its Nanoparticlesmentioning

confidence: 99%

Polysaccharide Based Nanoparticles

Khan

Abtew

Modani

et al. 2018

Israel Journal of Chemistry

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Nanoparticles made of biodegradable polymers have outstanding merits as a drug delivery system. Polysaccharide-based nanoparticles have been well explored because of their safety, stability, biocompatibility, biodegradability and hydrophilicity. The present review emphasizes the efforts articulated to improve polysaccharide-based nano-particles as drug delivery tool for effective therapy and sitespecific targeting of mainly anticancer agents. This review updates reports of recent research on polysaccharides-based systems particularly chitosan, alginate, cyclodextrins, hyaluronic acid, pullulan, dextran and their combinations with potential applications.

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“…Oral administration is the best therapeutic way for intestinal diseases because it is regarded as the simplest and fastest method for drugs to reach the intestine and contact with the target site directly. [ 8 ] To meet the demand for oral administration, the oral drugs for intestinal protection should hold the following characteristics: i) Good stability and protective ability remain unchanged in the gastric juice environment. ii) Long residence time for drugs in the intestine is required for its high utilization.…”

Section: Introductionmentioning

confidence: 99%

Clinically Approved Carbon Nanoparticles with Oral Administration for Intestinal Radioprotection via Protecting the Small Intestinal Crypt Stem Cells and Maintaining the Balance of Intestinal Flora

Wang

Xie

Dong

et al. 2020

Small

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The exploration of an old drug for new biomedical applications has an absolute predominance in shortening the clinical conversion time of drugs for clinical application. In this work, carbon nanoparticles suspension injection (CNSI), the first clinically approved carbon nanoparticles in China, is explored as a new nano‐radioprotective agent for potent intestinal radioprotection. CNSI shows powerful radioprotective performance in the intestine under oral administration, including efficient free radical scavenging ability, good biosafety, high chemical stability, and relatively long retention time. For example, CNSI shows high reactive oxygen species (ROS) scavenging activities, which effectively alleviates the mitochondrial dysfunction and DNA double‐strand breaks to protect the cells against radiation‐induced damage. Most importantly, this efficient ROS scavenging ability greatly helps restrain the apoptosis of the small intestinal epithelial and crypt stem cells, which decreases the damage of the mechanical barrier and thus relieves radiation enteritis. Moreover, CNSI helps remove the free radicals in the intestinal microenvironment and thus maintain the balance of intestinal flora so as to mitigate the radiation enteritis. The finding suggests a new application of clinically approved carbon nanoparticles, which not only promotes the development of new intestinal radioprotector, but also has a great potential for clinical transformation.

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Development of a Drug Delivery System Based on Chitosan Nanoparticles for Oral Administration of Interferon-α

Cited by 65 publications

References 31 publications

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Polysaccharide Based Nanoparticles

Clinically Approved Carbon Nanoparticles with Oral Administration for Intestinal Radioprotection via Protecting the Small Intestinal Crypt Stem Cells and Maintaining the Balance of Intestinal Flora

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