Development of a device for detecting target specimens from EUS-guided FNA samples

Abstract

Background and study aims: Specimens collected by fine needle are microscopic and contain blood; therefore, the presence of a target specimen within a sample is often difficult to confirm. Although rapid on-site evaluation (ROSE) during endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) is beneficial, many health care facilities are unable to apply this technique due to a lack of cytopathologists. The aim of this study was to develop and validate a device that detects the target specimen within pancreatic tumor EUS-FNA samples. Patients and methods: Fifty-eight consecutive patients with solid pancreatic masses were studied for a preliminary case series at a tertiary-care university hospital (Tottori University Hospital, Yonago, Japan). The material collected was checked with a target sample check illuminator (TSCI) and was evaluated by one cytopathologist. Results: The agreement rate between the TSCI and histopathology was 93.7 %. Further testing procedures were not needed in 91.4 % of patients, and the mean number of needle punctures was 1.2 after a single pass using TSCI. No adverse events were encountered with the procedure. Conclusions: With the introduction of the TSCI in EUS-FNA, it became possible to both collect the minimum necessary target samples by EUS-FNA and to end further procedures, even without performing ROSE.

A “Back Light System” for Identification of Sites for Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Solid Pancreatic Masses: A Prospective, Randomized Study with a Crossover Design

“…Our data indicate better results, but our findings and those reported by Nguyen et al cannot be compared because of the differences in patient backgrounds and the method by which the specimens were processed [25]. Matsumoto et al showed good agreement with a target sample check illuminator (TSCI) [26]. The TSCI can use the 605-nm wavelength, which may account for differences.…”

Efficacy and safety of pancreatic juice cytology by using synthetic secretin in the diagnosis of pancreatic ductal adenocarcinoma

“…Furthermore, there are still some areas or hospitals where patients cannot receive EUS‐FNA. Although the overall complication rate for EUS‐FNA has been reported as 2% and research to decrease the complication rate has been reported, it is not free from complications. Complications include pain, bleeding, fever, and infection.…”

Randomized Controlled Trial Comparing the Usefulness of Endoscopic Ultrasound Processor

“…Whether tissue sampling could be performed was determined visually by the endoscopist and using the Target Sample check illuminator (TSCI), which we developed and previously reported on its utility. 12 If sample collection was not successful the fi rst time, an additional puncture was performed.…”