Development of a desktop-sized thermal lens microscope

Hiki, Shinichiro; Tokeshi, Manabu; Hibara, Akihide; Kitamori, Takehiko

doi:10.2116/bunsekikagaku.52.569

Cited by 15 publications

(9 citation statements)

References 12 publications

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“…They have since been integrated and commercialized as desktop- [76] and palm-sized TLMs [46], as shown in Figure 8. In the palm-sized TLM, laser diodes are used for the excitation and probe beams, which are introduced into a microchannel via a light mixer and a single-mode optical fiber.…”

Section: Single Molecule Detection Methodsmentioning

confidence: 99%

Microflow Systems for Chemical Synthesis and Analysis: Approaches to Full Integration of Chemical Process

Mawatari¹,

Kazoe²,

Aota³

et al. 2011

J Flow Chem

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Integrated microchemical systems on microchips, which are based on continuous microflows, are expected to become important tools for analysis and chemical synthesis applications for biological sciences and technologies. For these purposes, general integration concepts have been developed, including microunit operations (MUOs) and continuousflow chemical processing (CFCP) to create fully functional systems for various chemical processing applications. The general methodology has enabled analysis, synthesis, and fabrication of chemical systems on microchips, and these microsystems have demonstrated superior performance (e.g., rapid, simple, easy operation, and highly efficient processing) compared to conventional methodologies. Microchemical technology has now entered the phase of practical application. In this review, we discuss the methods for integration of continuous flow-based chemical process on microchips, relevant technologies, and applications.

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Section: Single Molecule Detection Methodsmentioning

confidence: 99%

Microflow Systems for Chemical Synthesis and Analysis: Approaches to Full Integration of Chemical Process

Mawatari¹,

Kazoe²,

Aota³

et al. 2011

J Flow Chem

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“…However, the need for the careful alignment of laser beams, the cost of lasers, and a complicated system of optical elements still limit TLM applicability. Using diode lasers, Hiki and co‐authors showed the potential of the desktop‐sized thermal‐lens microscope (DT‐TLM) and made the detection system less expensive and more portable, which enabled novel applications, including combination with capillary and on‐chip electrophoresis. However, the existing DT‐TLM design exposed some drawbacks such as inherited adjustment complications and insufficient signal stability, which hindered the detection sensitivity.…”

Section: Laser Parameters Of Dt‐tlmsmentioning

confidence: 99%

Desktop near‐field thermal‐lens microscope for thermo‐optical detection in microfluidics

et al. 2012

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A new compact near-field desktop-sized diode laser thermal-lens microscope for analysis in microfluidics was proposed. A novel beam-alignment and detection systems provided high signal stability and, along with reduced number of optical elements rendered the instrument portable. The detection of nonfluorescent model species (Fe(II)-bathophenanthroline chelate) in water showed good linearity in the range of 5 × 10(-9) to 1 × 10(-4) M, and the limit of detection was 3.5 × 10(-9) M, which corresponded to 3.5 × 10(-7) absorbance units and provided a 20-fold enhancement in sensitivity compared with existing schematic.

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“…It has demonstrated sensitive detection on a nanogram level. 96 By combining continuous reaction and TLM, various kinds of chemical procedures have been integrated into microchips.…”

Section: Extraction and Detection Of Carbarylmentioning

confidence: 99%

Microstructured Reactors for Multiphase Reactions: State of the Art

Kashid

Kiwi‐Minsker

2009

Ind. Eng. Chem. Res.

202

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The manufacture of chemicals in microstructured reactors (MSR) has become recently a new branch of chemical reaction engineering focusing on process intensification and safety. MSR have an equivalent hydraulic diameter up to a few hundreds of micrometers and, therefore, provide high mass-and heat-transfer efficiency increasing the reactor performance drastically, compared to the conventional one. This article provides a comprehensive overview of the state of the art of the MSR applied for multiphase reactions. The reactions are classified based on the number of phases involved: fluid-fluid, fluid-solid, and three phase reactions. In the first part of the review, limitations of conventional reactors are discussed in brief. Furthermore, different types of MSR and their advantages with respect to their conventional counterparts are described. Particular attention is given to the identification of the parameters that control the flow pattern formed in microcapillaries regarding the mass-transfer efficiency. Case studies of various multiphase reactions carried out in MSR are discussed in detail.

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Development of a desktop-sized thermal lens microscope

Cited by 15 publications

References 12 publications

Microflow Systems for Chemical Synthesis and Analysis: Approaches to Full Integration of Chemical Process

Microflow Systems for Chemical Synthesis and Analysis: Approaches to Full Integration of Chemical Process

Desktop near‐field thermal‐lens microscope for thermo‐optical detection in microfluidics

Microstructured Reactors for Multiphase Reactions: State of the Art

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