Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions

“…Among its advantages, EREFS provide uniform language that: 1) is a validated grading and classification system 28,64 ; 2) is accurate in predicting EoE diagnosis and histologic remission in both children and adults 65,66 ; 3) has been reliably used for both observational and randomized controlled clinical studies of adult patients 67,68 ; and 4) is a major determinant of gastroenterologists' assessment of disease activity. 46 Disadvantages include 1) not being commonly reported in studies of pediatric EoE patients; 2) lack of agreement among many endoscopists, until recently, on EREFS scoring; 3) difficulty of use in daily clinical practice in centers not specializing in EoE 35 ; and 4) lack of incorporation into all endoscopy reporting platforms. Simplified versions of EREFS that collapse scoring of individual features to "absent" or "present" have comparable inter-and intrarater intraclass correlation coefficients, but are likely less reflective of response to therapy.…”

“…Over the course of the last 20 years, clinical experiences and research studies have identified key features needed to begin to prospectively assess EoE clinical severity. Development of patient-reported outcomes, [25][26][27] endoscopic assessment platforms, 28 and histologic metrics of disease activity, 20,[29][30][31][32][33][34] and even a clinical outcomes set, 35 provided robust metrics to measure patients' responses to treatments and assess disease activity. However, no published guidance has combined all elements of disease activity into a single score that could be applied in a practitioner's office to follow and risk stratify patients with EoE.…”

Endoscopic approach to eosinophilic esophagitis: American Society for Gastrointestinal Endoscopy Consensus Conference

“…71,95 Although dilation treats 1 of the sequelae of EoE (ie, fibrosis/narrowing), it is not effective at treating the underlying cause of the disease (ie, eosinophilic-predominant esophageal inflammation). 65 EoE leads to subepithelial fibrous remodeling, 121 which perturbs esophageal function and leads to dysmotility, 122 esophageal rigidity, 123 and dysphagia. Even when patients may have achieved endoscopic and histologic remission of their disease, longstanding inflammation can result in irreversible structural changes within the esophagus.…”

Mast cell‐pain connection in eosinophilic esophagitis

“…1,2 Additionally, dysbiosis of oral microbiota (OM) has been implicated in the pathogenesis of allergic diseases. 3 Despite recent evidence of the associations between OM and oral mucosa immunity in peanut allergy, 4 the potential links between OM and the host oral milieu in different sensitization patterns are overlooked. Here, we report a novel and multi-omic study using saliva as a useful tool to explore a distinct OM-oral environment relationship in polysensitized atopic individuals.…”