Development of a continuous dense gas process for the production of liposomes

Lesoin, L.; Crampon, Christelle; Boutin, Olivier; Badens, Elisabeth

doi:10.1016/j.supflu.2011.04.018

Cited by 46 publications

(31 citation statements)

References 44 publications

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“…In this procedure, a phospholipid solution is sprayed through supercritical carbon dioxide, causing the rapid evaporation of the solvent [47]. This leads to phospholipid precipitation as empty vesicles that can then be rehydrated using a range of aqueous solutions.…”

Section: Preparation Of Liposomesmentioning

confidence: 99%

Design of liposomal formulations for cell targeting

Nogueira

Gomes

Preto

et al. 2015

Colloids and Surfaces B: Biointerfaces

138

103

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Liposomes have gained extensive attention as carriers for a wide range of drugs due to being both nontoxic and biodegradable as they are composed of substances naturally occurring in biological membranes. Active targeting for cells has explored specific modification of the liposome surface by functionalizing it with specific targeting ligands in order to increase accumulation and intracellular uptake into target cells. None of the Food and Drug Administration-licensed liposomes or lipid nanoparticles are coated with ligands or target moieties to delivery for homing drugs to target tissues, cells or subcellular organelles. Targeted therapies (with or without controlled drug release) are an emerging and relevant research area. Despite of the numerous liposomes reviews published in the last decades, this area is in constant development. Updates urgently needed to integrate new advances in targeted liposomes research. This review highlights the evolution of liposomes from passive to active targeting and challenges in the development of targeted liposomes for specific therapies.

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Section: Preparation Of Liposomesmentioning

confidence: 99%

Design of liposomal formulations for cell targeting

Nogueira

Gomes

Preto

et al. 2015

Colloids and Surfaces B: Biointerfaces

138

103

View full text Add to dashboard Cite

show abstract

“…Recently, some techniques based on the use of supercritical CO 2 (scCO 2 ) have been proposed also for liposome preparation [18][19][20][21][22][23]; they try to take the advantage of the enhanced mass transfer of supercritical fluids [24] and can be divided in two categories: two steps processes in which the dried lipid particles need to be rehydrated [11,22,[25][26][27][28], and one step processes in which a liposome-water suspension is directly obtained at the end of the process [29][30][31]. These processes have still some limitations related to the control of liposome dimension and distribution and also show very low encapsulation efficiencies, especially for liposomes containing hydrophilic drugs.…”

Section: Introductionmentioning

confidence: 99%

Efficient encapsulation of proteins in submicro liposomes using a supercritical fluid assisted continuous process

Campardelli

Santo

Albuquerque

et al. 2016

The Journal of Supercritical Fluids

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“…For example, very recently, a technique based on the use of supercritical carbon dioxide has been developed [115].…”

Section: Methods Of Liposome Preparationmentioning

confidence: 99%

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

et al. 2016

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Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient. To this scope, due to their unique features, nanostructured materials have emerged as attractive elements for the development of multifunctional tools for diagnosis and therapy. Hence, in this review, the most recent and relevant advances achieved by applying multifunctional nanostructures in multimodal theranosis of different diseases will be discussed. In more detail, the preparation and application of single multifunctional nano-radiotracers based on iron oxides and enabling PET/MRI dual imaging will be firstly detailed. After that, especially considering their highly promising clinical potential, the preparation and application of multifunctional liposomes useful for multimodal imaging and therapy will be reviewed. In both cases, a special focus will be set on the application of such a multifunctional nanocarriers in cancer as well as cardiovascular diseases.

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Development of a continuous dense gas process for the production of liposomes

Cited by 46 publications

References 44 publications

Design of liposomal formulations for cell targeting

Design of liposomal formulations for cell targeting

Efficient encapsulation of proteins in submicro liposomes using a supercritical fluid assisted continuous process

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

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