Development of a computational model for acute ischemic stroke recanalization through cyclic aspiration

Good, Bryan C.; Simon, Scott D.; Manning, Keefe B.; Costanzo, Francesco

doi:10.1007/s10237-019-01247-w

Cited by 17 publications

(44 citation statements)

References 43 publications

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“…However, none of these studies focus on the dependence of aspiration outcomes on clot-length, and do not include any modeling of the clot-artery interface, which is essential for understanding the limitations of the procedure. In this study, we numerically investigate the deformation and failure mechanisms of long clots during cyclic aspiration by modeling the clot as a viscoelastic solid clot, the artery as a hypereleastic solid, and the clot-artery interface as a nonlinear viscoelastic cohesive zone, following the framework in [14] and [34].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the data on cerebral arteries is even limited, due to a lack of pragmatic mechanical catheterization [26]. In this context, several previous numerical studies on aspiration have modeled the arterial wall as rigid [7, 14, 35, 42]. The Romero and Talayero groups have used a simplified, linear elastic model for the artery [38–41, 46, 47].…”

Section: Discussionmentioning

confidence: 99%

“…If we assume the cohesive interface to be made up of microscopic fibrils of length l , then the damage accumulation can be thought to be triggered by the failure of the fibrils (c.f. [14, 34]). When δ exceeds a critical value, δ cr , damage accumulation can be thought to be triggered.…”

Section: Numerical Frameworkmentioning

confidence: 99%

“…[8]), where the interface is modelled as a bio-film having negligible inertia. In previous studies, we used the developed computational framework to analyze the use of cyclic aspiration for the removal of clots from cerebral arteries, while treating the artery as rigid [14] and deformable [34].…”

Section: Introductionmentioning

confidence: 99%

“…Recanalization rates are highly dependent on the mechanical structure of the clot as well as the contact mechanics at the interface of the clot and inner wall of the occluded artery [53]. Hence, in order to accurately model the clot-artery interface, our group formulated a computational framework with an initial validation using benchtop experiments [14]. The framework makes use of accurate models to describe the behavior of clots and arteries and the clot-artery interface.…”

Section: Introductionmentioning

confidence: 99%

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Computational Analysis of Effects of Clot Length on Acute Ischemic Stroke Recanalization under Different Cyclic Aspiration Loading Conditions

Patki

Simon

Manning

et al. 2022

Preprint

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Acute ischemic stroke, the second leading cause of death worldwide, results from occlusion of a cerebral artery by a blood clot. Application of cyclic aspiration using an aspiration catheter is a current therapy for the removal of lodged clots. In this study, we perform finite element simulations to analyze deformation of long clots, having length to radius ratio of 2 to 10, which corresponds to clot-length of 2.85–14.25 mm, under peak-to-peak cyclic aspiration pressures of 10 to 50 mmmHg, and frequencies of 0.5, 1 and 2 Hz. Our computational system comprises of a nonlinear viscoelastic solid clot, a hyperelastic artery, and a nonlinear viscoelastic cohesive zone, the latter modeling the clot–artery interface. We observe that clots having length-to-radius ratio approximately greater than two separate from the inner arterial surface somewhere between the axial and distal ends, irrespective of the cyclic aspiration loading conditions. The stress distribution within the clot shows large tensile stresses in the clot interior, indicating the possibility of simultaneous fragmentation of the clot. Thus, this study shows us the various failure mechanisms simultaneously present in the clot during cyclic aspiration. Similarly, the stress distribution within the artery implies a possibility of endothelial damage to the arterial wall near the end where the aspiration pressure is applied. This framework provides a foundation for further investigation to clot fracture and adhesion characterization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Numerical Frameworkmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Computational Analysis of Effects of Clot Length on Acute Ischemic Stroke Recanalization under Different Cyclic Aspiration Loading Conditions

Patki

Simon

Manning

et al. 2022

Preprint

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Computational analysis of effects of clot length on Acute ischemic stroke recanalization under different cyclic aspiration loading conditions

Patki

Simon

Manning

et al. 2022

Numer Methods Biomed Eng

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Acute ischemic stroke, the second leading cause of death worldwide, results from occlusion of a cerebral artery by a blood clot. Application of cyclic aspiration using an aspiration catheter is a current therapy for the removal of lodged clots. In this study, we perform finite element simulations to analyze deformation of long clots, having length to radius ratio of 2–10, which corresponds to clot‐length of 2.85–14.25 mm, under peak‐to‐peak cyclic aspiration pressures of 10–50 mmHg, and frequencies of 0.5, 1, and 2 Hz. Our computational system comprises of a nonlinear viscoelastic solid clot, a hyperelastic artery, and a nonlinear viscoelastic cohesive zone, the latter modeling the clot–artery interface. We observe that clots having length‐to‐radius ratio approximately greater than two separate from the inner arterial surface somewhere between the axial and distal ends, irrespective of the cyclic aspiration loading conditions. The stress distribution within the clot shows large tensile stresses in the clot interior, indicating the possibility of simultaneous fragmentation of the clot. Thus, this study shows us the various failure mechanisms simultaneously present in the clot during cyclic aspiration. Similarly, the stress distribution within the artery implies a possibility of endothelial damage to the arterial wall near the end where the aspiration pressure is applied. This framework provides a foundation for further investigation to clot fracture and adhesion characterization.

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A one‐dimensional computational model for blood flow in an elastic blood vessel with a rigid catheter

Pradhan,

Mut,

Cebral

2024

Numer Methods Biomed Eng

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Strokes are one of the leading causes of death in the United States. Stroke treatment involves removal or dissolution of the obstruction (usually a clot) in the blocked artery by catheter insertion. A computer simulation to systematically plan such patient‐specific treatments needs a network of about 105 blood vessels including collaterals. The existing computational fluid dynamic (CFD) solvers are not employed for stroke treatment planning as they are incapable of providing solutions for such big arterial trees in a reasonable amount of time. This work presents a novel one‐dimensional mathematical formulation for blood flow modeling in an elastic blood vessel with a centrally placed rigid catheter. The governing equations are first‐order hyperbolic partial differential equations, and the hypergeometric function needs to be computed to obtain the characteristic system of these hyperbolic equations. We employed the Discontinuous Galerkin method to solve the hyperbolic system and validated the implementation by comparing it against a well‐established 3D CFD solver using idealized vessels and a realistic truncated arterial network. The results showed clinically insignificant differences in steady flow cases, with overall variations between 1D and 3D models remaining below 10%. Additionally, the solver accurately captured wave reflection phenomena at domain discontinuities in unsteady cases. A primary advantage of this model over 3D solvers is its ease in obtaining a discretized geometry of complex vasculatures with multiple arterial branches. Thus, the 1D computational model offers good accuracy and applicability in simulating complex vasculatures, demonstrating promising potential for investigating patient‐specific endovascular interventions in strokes.

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Development of a computational model for acute ischemic stroke recanalization through cyclic aspiration

Cited by 17 publications

References 43 publications

Computational Analysis of Effects of Clot Length on Acute Ischemic Stroke Recanalization under Different Cyclic Aspiration Loading Conditions

Computational Analysis of Effects of Clot Length on Acute Ischemic Stroke Recanalization under Different Cyclic Aspiration Loading Conditions

Computational analysis of effects of clot length on Acute ischemic stroke recanalization under different cyclic aspiration loading conditions

A one‐dimensional computational model for blood flow in an elastic blood vessel with a rigid catheter

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