Development of a colloidal gold strip assay for the detection of total homocysteine in serum samples

Abstract

Homocysteine (Hcy) is an amino acid found in the human body, which has the potential to predict cardiovascular risk where timely detection and treatment are very important. In this study,...

A prototype of ultrasensitive time-resolved fluoroimmunoassay for the quantitation of lead in plasma using a fluorescence-enhanced europium chelate label for the detection system

“…20 Most environmental immunoassays are directed toward organic compounds; 18,19 however, this technique applied to any analyte, including metals, if a suitable antibody can be generated. [20][21][22][23] Time-resolved uoroimmunoassay (TRFIA) is a type of immunoassay that has been developed in recent decades. 24 In these assays, chelates of rare-earth lanthanide elements such as Europium and samarium are used as labels because of their intrinsic high uorescence intensity, ability to overcome highbackground interferences, and delayed relaxation time.…”

“…20 Most environmental immunoassays are directed toward organic compounds; 18,19 however, this technique applied to any analyte, including metals, if a suitable antibody can be generated. 20–23…”

Profiling of Homocysteine Metabolic Pathway Related Metabolites in Plasma of Diabetic Mellitus Based on LC-QTOF-MS

“…In addition, studies have shown that certain diseases such as neonatal defects, arteriovenous thrombosis, diabetes, stroke, Alzheimer’s, and Parkinson’s disease are also associated with abnormal Hcy metabolism [ 9 , 11 , 12 ]. Since the high concentrations of Hcy can induce the risk of various diseases, a variety of methods for the detection of Hcy have been developed clinically to facilitate clinical diagnosis and prevention [ 13 , 14 , 15 ]. The biomarkers of DM have been studied by metabolomics, which also involve the metabolites on Hcy metabolism [ 16 ].…”