“…First, 15 nm colloidal gold nanoparticles (GNPs) were prepared according to the classical synthesis method. 40 Next, 200 mL of chloroauric acid solution (0.05 mM) was heated under vigorous stirring, then 5 mL of trisodium citrate (10 mg mL À1 ) was added the instant the solution started boiling. The color of the solution turned to blue, purple, and finally wine-red.…”
Section: Preparation Of Gnp-labeled Mabsmentioning
Tacrolimus is a macrolide immunosuppressant widely used in organ transplantation. Due to the narrow treatment window, therapeutic drug monitoring of the clinical application of tacrolimus is necessary. In this study,...
“…First, 15 nm colloidal gold nanoparticles (GNPs) were prepared according to the classical synthesis method. 40 Next, 200 mL of chloroauric acid solution (0.05 mM) was heated under vigorous stirring, then 5 mL of trisodium citrate (10 mg mL À1 ) was added the instant the solution started boiling. The color of the solution turned to blue, purple, and finally wine-red.…”
Section: Preparation Of Gnp-labeled Mabsmentioning
Tacrolimus is a macrolide immunosuppressant widely used in organ transplantation. Due to the narrow treatment window, therapeutic drug monitoring of the clinical application of tacrolimus is necessary. In this study,...
“…As a result, a wide range of analytical techniques for nicotine determination has emerged. These comprise of UV-visible spectroscopy [9], gas chromatography (GC) [10], high-performance liquid chromatography (HPLC) [11], capillary electrophoresis [12], and immunochromatographic strip [13]. HPLC-based methods require large amounts of organic solvents, laborious sample pre-processing stages and costly instrument, and they are not suitable for rapid analysis [11].…”
Section: Introductionmentioning
confidence: 99%
“…In the current UVvisible-based study, the respective disadvantages include the lengthy probe preparation time of over 40 h and a laborious sample preparation process lasting about 60 min involving multiple heating-cooling steps and the use of numerous chemicals [9]. Immunochromatographic strip, which is a new generation method for nicotine determination, has some drawbacks such as requiring antibodies and the synthesis of costly gold nanoparticles, having a moderate limit of detection (LOD) (i. e. 0.123 μM), being not tested in human fluids, and subjecting it to a 2-day process to convert the nicotine into analyzable form before analysis [13]. In contrast to these methods, electrochemical sensing techniques [1,2,[4][5][6][14][15][16][17][18][19][20][21][22] (Table S1) have gained significant relevance owing to their simplicity, speed, sensitivity, portability, selectivity, robustness, and cheapness.…”
“…NIC addiction is a global public health problem and has been receiving much attention. [1][2][3] Based on a large number of smokers, the cigarette industry can generate high profits and has become the highest tax industry in China. 4 Since the 1960s, due to strict restrictions on the tar content of tobacco products in various countries, low-tar cigarettes have been developed, which has led to a decrease in the aroma components in the smoke, and means that the overall aroma characteristics of cigarettes cannot be guaranteed.…”
Herein, the electrodeposition of paracetamol oxide (PA ox) for the intelligent portable ratiometric detection of nicotine (NIC) and ethyl vanillin β-d-glucoside (EVG) is reported.
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