Development of a co-culture system for green production of caffeic acid from sugarcane bagasse hydrolysate
Xihui Wang,
Cui Zhao,
Xinyao Lu
et al.
Abstract:Caffeic acid (CA) is a phenolic acid compound widely used in pharmaceutical and food applications. However, the efficient synthesis of CA is usually limited by the resources of individual microbial platforms. Here, a cross-kingdom microbial consortium was developed to synthesize CA from sugarcane bagasse hydrolysate using Escherichia coli and Candida glycerinogenes as chassis. In the upstream E. coli module, shikimate accumulation was improved by intensifying the shikimate synthesis pathway and blocking shikim… Show more
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