Development of a Carotid Vulnerable Plaque Phantom Model Evaluated by Pixel Distribution Analysis

Yau, Olivia; Hétu, Marie-France; Herr, Julia E.; Adams, Michael; Johri, Amer M.

doi:10.1016/j.ultrasmedbio.2018.07.005

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…To verify the advantages of AgNR@SiO 2 heterostructures for enhancing OCT imaging in the NIR‐II window, a second type of phantom mimicking tissue with vessels was constructed. [ 38 ] Specifically, a PVA solution was injected into a mold embedded with small wires, forming a phantom with small channels following solidification. DI water and aqueous solutions of AgNR@mSiO 2 with a concentration of 150 × 10 −12 m were injected into the channels for OCT imaging.…”

Section: Figurementioning

confidence: 99%

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

Zhou

Zhuang

et al. 2020

Advanced Optical Materials

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Optical coherence tomography (OCT) is a noninvasive bio‐imaging modality that is widely used in both fundamental research and clinical practice. Contrast agents with strong light‐scattering properties are a prerequisite for OCT imaging. Bio‐imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has recently attracted significant attention based on reduced light absorption, suppressed photon scattering, and negligible autofluorescence. OCT contrast agents with both strong light‐scattering cross‐sections in the NIR‐II window and excellent biocompatibility are highly desirable. In this article, Ag‐based rod‐shaped plasmonic nanostructures are presented as NIR‐II OCT contrast agents. As a high‐aspect‐ratio heterostructure, the Ag nanorods coated with mesoporous silica shells (AgNR@mSiO2) are developed to achieve plasmon resonance at 1330 nm and excellent biocompatibility. By taking advantage of their huge light‐scattering cross‐sections, which provide the strongest scattering reported to date among various nanoscale OCT contrast agents, the heterostructures are used to perform efficient in vivo OCT imaging of crucian carp eyes and chicken blood vessels in the NIR‐II window. The captured images exhibit enhanced contrast with large imaging depth. These results demonstrate that the developed AgNR@mSiO2 heterostructures are promising OCT contrast agents, that can provide guidance and reference for the development of highly efficient NIR‐II imaging probes.

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Section: Figurementioning

confidence: 99%

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

Zhou

Zhuang

et al. 2020

Advanced Optical Materials

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Atherosclerotic carotid bifurcation phantoms with a stenotic soft inclusion for flow-structure ultrasound imaging analysis

Chayer

Hoven

Cardinal

et al. 2019

2019 IEEE International Ultrasonics Symposium (IUS)

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Optimizing the Ultrasound Image Quality of Carotid Artery Stenosis Patients via Taguchi’s Dynamic Analysis and an Indigenous Water Phantom

Hsiao

Lin

et al. 2022

Applied Sciences

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This study optimized the ultrasound image of carotid artery stenosis using Taguchi dynamic analysis and an indigenous water phantom. Eighteen combinations of seven essential factors of the ultrasound scan facility were organized according to Taguchi’s L18 orthogonal array. The seven factors were assigned as follows: (1) angle of probe; (2) signal gain; (3) resolution vs. speed; (4) dynamic range; (5) XRES; (6) zoom; (7) time gain compensation. An indigenous water phantom was customized to satisfy the quantified need in Taguchi’s analysis. Unlike the conventional dynamic Taguchi analysis, an innovative quantified index, the figure of merit (FOM), was proposed to integrate four specific quality characteristics, namely (i) average difference between the practical scan and theoretically preset area (78.5, 50.2 and 12.6 mm2) of stenosis, (ii) standard deviation of the average, (iii) practical scan’s sensitivity β to various stenosis diameters (10, 8, and 4 mm), and (iv) correlation coefficient r2 of the linear regressed sensitivity curve. The highest value (FOM = 0.413) was furnished by the optimal combination of factors on 18 groups under study, yielding high r2 and low β or standard deviation values and the best quality of ultrasound images for the further clinical diagnosis. The comparison between FOM and the conventional signal-to-noise (S/N) ratio in Taguchi’s analysis revealed that FOM compiled more quality characteristics that were superior by nature to fulfill the practical need in clinical diagnosis. The alternative choice in ultrasound scan optimization can be based on stenosis diameter variation from a different perspective to be explored in the follow-up study.

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Development of a Carotid Vulnerable Plaque Phantom Model Evaluated by Pixel Distribution Analysis

Cited by 3 publications

References 32 publications

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

High‐Aspect‐Ratio Plasmonic Heterostructures for In Vivo Enhanced Optical Coherence Tomography Imaging in the Second Near‐Infrared Biological Window

Atherosclerotic carotid bifurcation phantoms with a stenotic soft inclusion for flow-structure ultrasound imaging analysis

Optimizing the Ultrasound Image Quality of Carotid Artery Stenosis Patients via Taguchi’s Dynamic Analysis and an Indigenous Water Phantom

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