Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change

Gralnek, Ian M.; DeFranchis, Roberto; Seidman, Ernest G.; Leighton, Jonathan A.; Legnani, Peter; Lewis, Blair S.

doi:10.1111/j.1365-2036.2007.03556.x

Cited by 379 publications

(295 citation statements)

References 22 publications

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“…1 and 2). When any of these inflammatory lesions were seen we used the Lewis Score (LS) to assess severity: normal mucosa or non-significant inflammation, LS < 135; mild-moderate inflammation, LS: 135-790; severe mucosal affectation, LS > 790 (10,11).…”

Section: Classification Of Ce Findingsmentioning

confidence: 99%

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Valenzuela¹,

López²,

Fernández³

et al. 2016

Rev Esp Enferm Dig

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Background and aims:Capsule endoscopy is an extended tool for the diagnosis of small bowel Crohn's disease. However, factors associated with positive findings of this technique have not been well established. Our aim is to asses which factors are associated with a better diagnostic yield of capsule endoscopy in suspected small bowel Crohn's disease.Material and methods: This was a retrospective study including patients under capsule endoscopy because of suspected small bowel Crohn's disease. Demographic data of these patients, as well as symptoms and laboratory data including hemoglobin levels, count of leucocytes and platelets, and levels of C-reactive protein, erythrocyte sedimentation rate and fecal calprotectin were collected. Capsule endoscopy studies were classified as negative (no lesions) or positive (lesions suggestive of Crohn's disease). Descriptive, univariate and multivariate analysis were done, as well as diagnostic yield tests of the different markers for predicting lesions in capsule studies.Results: One hundred and twenty-four patients were included (85 women and 39 men). The average age was 38.21 years. Levels of C-reactive protein and fecal calprotectin were the markers more frequently associated with positive findings in capsule endoscopy. Calprotectin presented the best sensitivity as isolated marker. The association of altered levels of C-reactive protein and calprotectin showed the best specificity and predictive values.Conclusions: C-reactive protein and fecal calprotectin are appropriate biomarkers for selecting patients with suspected Crohn's disease of the small bowel for capsule endoscopy studies.

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Section: Classification Of Ce Findingsmentioning

confidence: 99%

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Valenzuela¹,

López²,

Fernández³

et al. 2016

Rev Esp Enferm Dig

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“…A scoring system has been proposed to evaluate CD on the basis of CE findings of villous structure, ulceration and stenosis. Each variable is assessed by size and extent of the change [36] ; however, further studies are needed to clarify the helpfulness o f th i s s ys tem . T h e s c o r e p r ov i d e s a c o m m o n language to quantify mucosal changes associated with any inflammatory process.…”

Section: Crohn's Diseasementioning

confidence: 99%

Five years’ experience with capsule endoscopy in a single center

Kav¹,

Bayraktar²

2009

WJG

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Capsule endoscopy (CE) is a novel technology that facilitates highly effective and noninvasive imaging of the small bowel. Although its efficacy in the evaluation of obscure gastrointestinal bleeding (OGIB) has been proven in several trials, data on uses of CE in different small bowel diseases are rapidly accumulating in the literature, and it has been found to be superior to alternative diagnostic tools in a range of such diseases. Based on literature evidence, CE is recommended as a first-line investigation for OGIB after negative bidirectional endoscopy. CE has gained an important role in the diagnosis and follow-up of Crohn's disease and celiac disease and in the surveillance of small bowel tumors and polyps in selected patients. Capsule retention is the major complication, with a frequency of 1%-2%. The purpose of this review was to discuss the procedure, indications, contraindications and adverse effects associated with CE. We also review and share our five-year experience with CE in various small bowel diseases. The recently developed balloon-assisted enteroscopies have both diagnostic and therapeutic capability. At the present time, CE and balloon-assisted enteroscopies are complementary techniques in the diagnosis and management of small bowel diseases.

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“…The Rutgeerts' score is applied to the postoperative neoterminal ileum and can help predict the risk of clinical recurrence [34]. Recently developed capsule endoscopy as- Statement 2C " There are no validated diagnostic criteria for SBCE for the diagnosis of Crohn's disease sessment scores are based on the degree of villous oedema, ulceration and stenosis [35], or degree of inflammation, extent of disease and strictures [36], but need to be prospectively validated. Scores for diagnosis and for assessing the activity or severity of Crohn's disease by SBCE or DAE should correlate with clinical disease activity and influence therapeutic measures and outcome.…”

Section: Introductionmentioning

confidence: 99%

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

Bourreille¹,

Ignjatovic²,

Aabakken³

et al. 2009

Endoscopy

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Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change

Abstract: SUMMARY BackgroundCapsule endoscopy can identify small bowel mucosal inflammatory change. However, there has been no validated index for capsule endoscopy findings. This manuscript documents the development of such an index.

Cited by 379 publications

References 22 publications

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Five years’ experience with capsule endoscopy in a single center

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

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Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change

Abstract: SUMMARY BackgroundCapsule endoscopy can identify small bowel mucosal inflammatory change. However, there has been no validated index for capsule endoscopy findings. This manuscript documents the development of such an index.

Cited by 379 publications

References 22 publications

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Five years’ experience with capsule endoscopy in a single center

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

Contact Info

Product

Resources

About

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease

Fecal calprotectin and C-reactive protein are associated with positive findings in capsule endoscopy in suspected small bowel Crohns disease