Development of a candidate reference sample for the characterization of tip-enhanced Raman spectroscopy spatial resolution

Sacco, Alessio; Imbraguglio, Dario; Giovannozzi, Andrea Mario; Portesi, C.

doi:10.1039/c8ra03762k

Cited by 8 publications

(12 citation statements)

References 33 publications

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“…Third, the tip approach curve is fitted . As a reference sample, Sacco et al use thiol nanopatterns (suitable for STM and AFM) . Aligning the laser to the tip apex requires time and training.…”

Section: Discussionmentioning

confidence: 99%

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Challenges and Opportunities of Tip-Enhanced Raman Spectroscopy in Liquids

2021

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Tip-enhanced Raman spectroscopy (TERS) is an emerging technique with a large number of potential applications in different fields such as chemistry, physics, biology, life sciences, and materials science. TERS in liquids offers nondestructive and label-free topographical and chemical imaging of molecules and chemical reactions under native conditions at a nanometer scale. It combines Raman spectroscopy with scanning probe microscopy, providing a unique combination of chemical information and high spatial resolution. The versatility of TERS increases even further if it is modified for simultaneous electrochemical measurements. This paper reviews the recent progress of TERS in liquid, with a focus on molecular structures, interfaces, and chemical reactions studied to date. For example, TERS studies revealed nanoscale chemical images of various molecules containing a benzene ring such as thiophenol or carbon nanotubes. Additionally, heterogeneous catalytic reactions at the solid−liquid interface were investigated in a new way to gain a deeper insight into electrochemical processes. Furthermore, TERS measurements expanded our knowledge of several redox compounds and enabled new insights into various chemical transformations. Despite substantial progress, TERS in liquids is not yet a routine measurement method, and there are still several challenges to solve before TERS can unleash its full potential.

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Section: Discussionmentioning

confidence: 99%

“…For STM measurements, most tips are produced by the electrochemical etching of a metal wire. ,,,,− This feedback mode is limited by the conductive samples or very thin layers (monolayer), and measurements on biological samples are not possible …”

Section: Experimental Setupsmentioning

confidence: 99%

Challenges and Opportunities of Tip-Enhanced Raman Spectroscopy in Liquids

2021

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“…In this work, the graphene edge method was applied to several experimental configurations on two different dispersive confocal Raman microscopes: an unmodified commercial DXR™xi Raman Imaging system, from Thermo Fisher Scientific™, and a custom setup assembled with a DXR™ Raman spectroscope (by Thermo Fisher Scientific™) with an optical path modified to pass through a Ntegra™ scanning probe microscope (SPM), by NT-MDT ® ; the latter is in fact a tip-enhanced Raman spectroscopy (TERS) apparatus, [45,46] although for these measurements the Raman-enhancing probe was not mounted in order to employ it as a simple confocal Raman microscope. The DXRxi features a magnetic sample stage with a step size of (0.1 Â 0.1 Â 0.2) μm along the three Cartesian axes (x Â y Â z), where z is the direction of the optical axis.…”

Section: Methodsmentioning

confidence: 99%

Graphene edge method for three‐dimensional probing of Raman microscopes focal volumes

Sacco

Portesi

Giovannozzi

et al. 2021

J Raman Spectroscopy

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In this work, a layer of graphene was used as a standard material for the measurement of the dimensions of Raman microscopes focal volumes of different confocal Raman spectrometers equipped with different objectives and excitation laser wavelengths. This method consists in probing the volume near the focal point of the system by using a flat graphene monolayer sheet with a straight edge. Graphene was selected because of its high Raman cross section and mechanically and chemically stability, allowing fast measurements and easy manipulation. In this paper, a method to employ graphene to accurately and precisely measure the three dimensions of the focal volume of a Raman microscope is presented; scanning along the axial and lateral directions, it is possible to reconstruct the three dimensions of the focal volume. Furthermore, these operations can be combined in a single procedure which allows the measurement of projections of the volume on planes parallel to the optical axis. Knowledge of these parameters enable absolute quantification of Raman-active molecules and support high-resolution Raman imaging.

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“…It is also indicated as a suitable matrix for the analysis of small molecular compounds [ 40 ]. The other described incorporation of this highly valuable scaffold is as a reporter molecule [ 41 ], reporters for thiol interactions at the nanoparticle surface [ 42 ], fluorescent probe [ 43 , 44 , 45 ], sugar acceptor [ 46 ], Raman reporter [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ], an excellent substrate for fluorescence spectroscopy [ 57 ], photodimerizable and healable reactant [ 58 ], fluorescent dye [ 59 , 60 ], and probe molecule on gold-coated silicon nanowires [ 61 ].…”

Section: 7-mercapto-coumarinmentioning

confidence: 99%

Insight on Mercapto-Coumarins: Synthesis and Reactivity

El‐Sawy

Abdelwahab²,

Kirsch

2022

Molecules

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Mercapto (or sulfanyl)-coumarins are heterocycles of great interest in the development of valuable active structures in material and biological domains. They represent a highly exploitable class of compounds that open many possibilities for further chemical transformations. The present review aims to draw focus toward the synthetic applicability of various forms of mercapto-coumarins and their representations in pharmaceuticals and industries. This work covers the literature issued from 1970 to 2021.

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Development of a candidate reference sample for the characterization of tip-enhanced Raman spectroscopy spatial resolution

Abstract: Tip-Enhanced Raman Spectroscopy (TERS) imaging of self-assembled thiol monolayers' nanometric patterns.

Cited by 8 publications

References 33 publications

Challenges and Opportunities of Tip-Enhanced Raman Spectroscopy in Liquids

Challenges and Opportunities of Tip-Enhanced Raman Spectroscopy in Liquids

Graphene edge method for three‐dimensional probing of Raman microscopes focal volumes

Insight on Mercapto-Coumarins: Synthesis and Reactivity

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