Development of a buccal mucoadhesive film for fast dissolution: mathematical rationale, production and physicochemical characterization

Vila, Marta Maria Duarte Carvalho; Tardelli, Edgard Robles; Chaud, Marco V.; Tubino, Matthieu; Balcão, Victor M.

doi:10.3109/10717544.2013.851301

Cited by 22 publications

(15 citation statements)

References 21 publications

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“…The in vitro dissolution profiles of OL from the optimized film in SSF (pH ¼ 5.8) compared with OL powder are shown in Figure 5. The optimized fast dissolving film achieved almost complete dissolution within 10 min compared with only 55.34% dissolved for those containing crystalline drug (30 min) which were also compatible with fast dissolving films reported in the literature (Vila et al, 2014). These results indicated that the COAD used to prepare the films greatly enhanced the extent and rate of dissolution of OL from the prepared OFDF.…”

Section: Assessment Of In Vitro Disintegration and Dissolution Of Thesupporting

confidence: 76%

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

et al. 2016

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Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was performed using differential scanning calorimetry (DSC), Fourier transform infrared spectrometry (FTIR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). Dispersions with highest equilibrium solubility were formulated as fast dissolving oral films. Modeling and optimization of film formation were undertaken using artificial neural networks (ANNs). The results indicated co-amorphization of OL-ascorbic acid through H-bonding. The co-amorphous dispersions at 1:2 molar ratio showed more than 600-fold increase in solubility of OL. The model optimized fast dissolving film prepared from the dispersion was physically and chemically stable, demonstrated short disintegration time (8.5 s), fast dissolution (97% in 10 min) and optimum tensile strength (4.9 N/cm 2 ). The results of in vivo data indicated high bioavailability (144 ng h/mL) and maximum plasma concentration (14.2 ng/mL) compared with the marketed references. Therefore, the optimized co-amorphous OL-ascorbic acid fast dissolving film could be a valuable solution for enhancing the physicochemical and pharmacokinetic properties of OL.

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Section: Assessment Of In Vitro Disintegration and Dissolution Of Thesupporting

confidence: 76%

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

et al. 2016

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“…A buccal mucoadhesive fast dissolving film was developed using pullulan as the main component and physically evaluated for moisture content, disintegration time, and mucoadhesion. The films showed respective values 14%, 41.6 seconds and 40 kg/cm 2 for moisture content, disintegration time and mucoadhesive force, which were deemed appropriate (Vila et al, 2014). These values were not too different from that obtained in the current study.…”

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confidence: 58%

Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery

Khan

Trivedi

Mitchell

et al. 2016

European Journal of Pharmaceutical Sciences

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This study involves the development of thin oral solvent cast films for the potential delivery of the proton pump inhibitor, omeprazole (OME) via the buccal mucosa for paediatric patients. OME containing films were prepared from ethanolic gels (1% w/w) of metolose (MET) with polyethylene glycol (PEG 400) (0.5% w/w) as plasticiser, and L-arg (0.2% w/w) as a stabilizer and dried in an oven at 40°C. The blank and drug loaded films were divided into two groups, one group was subjected to supercritical carbon dioxide (scCO2) treatment and the other group untreated. The untreated and scCO2 treated films were then characterised using differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, hydration (swelling), mucoadhesion and in vitro drug dissolution studies. Treatment of the solvent cast films with scCO2 caused significant changes to the functional and physical properties of the MET films. The original drug loaded MET films showed a sustained release of OME (1 hour), whereas scCO2 treatment of the formulations resulted in fast dissolving films with more than 90% drug release within 15 minutes.

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“…In a recent work by Vila et al, a hydrogel of PVA was developed, integrating nitrofurazone, with a moisture content of approximately 18% (w/w). In another (recent) work by Vila et al., a fast dissolution film for buccal applications, made of the polymer pullulan, presented a moisture content of approximately 14% (w/w). In the present research work, the moisture contents of the hydrogels produced were lower (between 11.35%, w/w, and 12.53%, w/w), indicating that the drying process utilized was efficient to remove the water, producing dried hydrogels that can be stored for long periods of time because of their relatively low‐moisture content.…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of a Hydrogel Containing Silver Sulfadiazine for Antimicrobial Topical Applications

Jodar

Balcão

Chaud

et al. 2015

Journal of Pharmaceutical Sciences

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Development and optimization of a hydrogel with impregnated silver sulfadiazine was pursued, for antimicrobial topical applications. The selected hydrogel exhibited a homogeneous appearance, with whitish colloration and devoid of any fractures or cracks. The content in impregnated silver sulfadiazine was within established limits (1%, w/w) with a standard deviation of up to 1.28%. The hydrogel presented a good characteristic in relation to release of the active antimicrobial principle, verified through swelling tests and antimicrobial activity. The swelling tests indicated a higher increase in weight during the first 6 h of contact with a moist environment, with a maximum value of 266.00 ± 0.81, and with maintenance of the original shape of the hydrogel. The impregnated silver sulfadiazine presented antimicrobial activity, as expected, indicating a prolonged release of the drug. The infrared spectra of the hydrogel with impregnated silver sulfadiazine indicated that the drug did not engage in any bonds with the polymeric matrix, which otherwise could have reduced its antimicrobial activity. The mechanical resistance tests produced good results, indicating that the hydrogels may be utilized in different locations of the human body with skin lesions.

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Development of a buccal mucoadhesive film for fast dissolution: mathematical rationale, production and physicochemical characterization

Cited by 22 publications

References 21 publications

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery

Development and Characterization of a Hydrogel Containing Silver Sulfadiazine for Antimicrobial Topical Applications

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