Development of a Bioactive Polymeric Drug Eluting Coronary Stent Coating Using Electrospraying

McKittrick, Craig Martin; Cardona, Milovan Joe; Black, Richard A.; McCormick, Christopher

doi:10.1007/s10439-019-02346-6

Cited by 19 publications

(6 citation statements)

References 35 publications

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“…Such system has the potential to be applied in comfortable transdermal delivery of biological therapeutics. Another innovative way of creating systems for the gradual elution of drugs consists in the deposition of capsules on stents [186,187].…”

Section: Encapsulation Methodsmentioning

confidence: 99%

Electrospray: More than just an ionization source

et al. 2020

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is a potential-driven process of liquid atomization, which is employed in the field of analytical chemistry, particularly as an ionization technique for mass spectrometric analyses of biomolecules. In this review, we demonstrate the extraordinary versatility of the electrospray by overviewing the specifics and advanced applications of ESbased processing of low molecular mass compounds, biomolecules, polymers, nanoparticles, and cells. Thus, under suitable experimental conditions, ES can be used as a powerful tool for highly controlled deposition of homogeneous films or various patterns, which may sometimes even be organized into 3D structures. We also emphasize its capacity to produce composite materials including encapsulation systems and polymeric fibers. Further, we present several other, less common ES-based applications. This review provides an insight into the remarkable potential of ES, which can be very useful in the designing of innovative and unique strategies.

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Section: Encapsulation Methodsmentioning

confidence: 99%

Electrospray: More than just an ionization source

et al. 2020

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“…[ 10 , 11 ] Technologies such as bioactive polymeric drug release systems that control coating thickness, surface roughness, drug load, and drug elution kinetics are also making significant improvements. [ 12 ] However, there is no self‐reporting “early warning system” for stents that block and there are no intravascular stents able to detect the very earliest changes associated with vessel occlusion and the signs of thrombosis formation. The development of devices that can detect and report the dominant cell types involved and provide detection of early changes in real time from within the vessel is now becoming an increasing necessity.…”

Section: Introductionmentioning

confidence: 99%

Predicting Cardiovascular Stent Complications Using Self‐Reporting Biosensors for Noninvasive Detection of Disease

et al. 2022

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Self‐reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re‐block after deployment due to a wound response called in‐stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.

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“…The release of protein-binding drugs can be modified by the presence of proteins within release media. For characterisation of hydrophobic drug release, the media will often include agents to enhance solubility in order to better capture in vivo release, with the inclusion of ethanol ( 7 ) and Tween ( 8 ) having been reported. In common with the methods used for dissolution testing of more conventional pharmaceutical dosage forms, accelerated release studies can be performed through selection of release media with maximal drug solubility.…”

Section: Introductionmentioning

confidence: 99%

“…The standards governing the evaluation of drug release kinetics from implantable devices rely on similar testing apparatus and protocols, although are less well defined ( 14 ). For vascular implants that are exposed to blood flow, perfusion systems are often used to characterise drug release ( 15 ) although more simplified agitation systems have also been employed ( 7 ). Gentle agitation can be provided to mimic movement of extracellular fluid around other implantables, such as orthopaedic or subcutaneous devices.…”

Section: Introductionmentioning

confidence: 99%

How Does Fluid Flow Influence Drug Release from Drug Filled Implants?

2022

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Drug-filled implants (DFIs) have emerged as an innovative approach to control the delivery of drugs. These devices contain the drug within the structure of the implant itself and avoid the need to include additional drug carrier materials such as a polymers, which are often associated with inflammation and delayed healing/tissue regeneration at the implant site. One common feature of in vitro experiments to generate drug release profiles is stirring or agitation of the release medium. However, the influence of the resulting fluid flow on the rate of drug release from DFIs has yet to be quantified. In this paper we consider two DFIs, which although similar in shape and size, employ different strategies to control the release of drug: a porous pin with pores on the order of μm and a pin drilled with orifices of the order of mm. We develop a multiphysics mathematical model of drug release from these DFIs, subject to fluid flow induced through stirring and show that fluid flow greatly influences the drug release profile for the orifice pin, but that the porous pin drug release profile is relatively insensitive to flow. We demonstrate that drug release from the porous pin may adequately be described through a simplified radial 1D dissolution-diffusion model, while a 3D dissolution-advection-diffusion model is required to describe drug release from the orifice pin. A sensitivity analysis reveals that that the balance of reaction-advection-diffusion in terms of key nondimensional numbers governs the overall drug release. Our findings potentially have important implications in terms of devising the most relevant experimental protocol for quantifying drug release from DFIs.

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Development of a Bioactive Polymeric Drug Eluting Coronary Stent Coating Using Electrospraying

Abstract: Associate Editor Smadar Cohen oversaw the review of this article.

Cited by 19 publications

References 35 publications

Electrospray: More than just an ionization source

Electrospray: More than just an ionization source

Predicting Cardiovascular Stent Complications Using Self‐Reporting Biosensors for Noninvasive Detection of Disease

How Does Fluid Flow Influence Drug Release from Drug Filled Implants?

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