Development of 99mTc(CO)3-dendrimer-FITC for cancer imaging

Tassano, Marcos; Audicio, Paola; Gambini, Juan; Fernández, Marcelo; Damian, Juan P.; Moreno, Marı́a; Chabalgoity, José A.; Alonso, Ómar; Benech, Juan Claudio; Cabral, Pablo

doi:10.1016/j.bmcl.2011.06.079

Cited by 20 publications

(16 citation statements)

References 36 publications

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“…Recently, another direct labeling procedure has been developed and applied to dendrimers via the tricarbonyl precursor [ 99m Tc(H 2 O) 3 (CO) 3 ] + by Tassano et al . . A freshly prepared precursor was mixed with the dendrimers and left at RT for 15min.…”

Section: Mtc‐radiolabeling Of Npsmentioning

confidence: 99%

Radiolabeling approaches of nanoparticles with ^99mTc

Psimadas

Bouziotis

Georgoulias

et al. 2013

Contrast Media & Molecular

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Nanomedicine applications have recently gathered great attention in terms of their revolutionary properties and multivalency. Nanoparticles (NPs) have proven useful owing to their size, surface and kinetics advantages, as well as their ability to be functionalized with targeting, imaging and therapeutic moieties. Nuclear medicine is actively involved in nano-research innovative breakthrough efforts in multiple applications, through the radiolabeling of NP structures. There are several ways that NP-radiolabeling can be approached depending on the radionuclide that is used and the NP type. The radiolabeling of NPs with the most widely and easily available radiometal, which is (99m) Tc, is the focus of this review.

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Section: Mtc‐radiolabeling Of Npsmentioning

confidence: 99%

Radiolabeling approaches of nanoparticles with ^99mTc

Psimadas

Bouziotis

Georgoulias

et al. 2013

Contrast Media & Molecular

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“…It has been shown that colon cancers can be imaged using two labelled mucins, one binding to cancerous cells, other to healthy cells 27 . The use of FITC-labelled dendrimers bound to cancerous cells in imaging has also been successfully validated 28 29 .…”

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confidence: 99%

Wireless fluorescence capsule for endoscopy using single photon-based detection

Al-Rawhani

Beeley

Cumming

2015

Sci Rep

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Fluorescence Imaging (FI) is a powerful technique in biological science and clinical medicine. Current FI devices that are used either for in-vivo or in-vitro studies are expensive, bulky and consume substantial power, confining the technique to laboratories and hospital examination rooms. Here we present a miniaturised wireless fluorescence endoscope capsule with low power consumption that will pave the way for future FI systems and applications. With enhanced sensitivity compared to existing technology we have demonstrated that the capsule can be successfully used to image tissue autofluorescence and targeted fluorescence via fluorophore labelling of tissues. The capsule incorporates a state-of-the-art complementary metal oxide semiconductor single photon avalanche detector imaging array, miniaturised optical isolation, wireless technology and low power design. When in use the capsule consumes only 30.9 mW, and deploys very low-level 468 nm illumination. The device has the potential to replace highly power-hungry intrusive optical fibre based endoscopes and to extend the range of clinical examination below the duodenum. To demonstrate the performance of our capsule, we imaged fluorescence phantoms incorporating principal tissue fluorophores (flavins) and absorbers (haemoglobin). We also demonstrated the utility of marker identification by imaging a 20 μM fluorescein isothiocyanate (FITC) labelling solution on mammalian tissue.

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“…In vivo Biodistribution of 99m Tc(CO) 3 -dendrimer-FITC was carried out with C57BL/6 mice and melanoma-bearing mice. 231 For both cases, accumulation was observed in hepatic, renal and bladder. Scintigraphic imaging showed high uptake in liver and kidney for melanoma-bearing mice.…”

Section: Metal-containing Polymeric Drugs and Biocidesmentioning

confidence: 91%

Metal-containing and related polymers for biomedical applications

et al. 2016

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A survey of the most recent progress in the biomedical applications of metal-containing polymers is given. Due to the unique optical, electrochemical, and magnetic properties, at least 30 different metal elements, most of them transition metals, are introduced into polymeric frameworks for interactions with biology-relevant substrates via various means. Inspired by the advance of metal-containing small molecular drugs and promoted by the great progess in polymer chemistry, metal-containing polymers have gained momentum during recent decades. According to their different applications, this review summarizes the following biomedical applications: 1) metal-containing polymers as drug delivery vehicles; 2) metal-containing polymeric drugs and biocides, including antimicrobial and antiviral agents, anticancer drugs, photodynamic therapy agents, radiotherapy and biocide; 3) metal-containing polymers as biosensors, and 4) metal-containing polymers in bioimaging.

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Development of 99mTc(CO)3-dendrimer-FITC for cancer imaging

Cited by 20 publications

References 36 publications

Radiolabeling approaches of nanoparticles with ^99mTc

Radiolabeling approaches of nanoparticles with ^99mTc

Wireless fluorescence capsule for endoscopy using single photon-based detection

Metal-containing and related polymers for biomedical applications

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Development of 99mTc(CO)3-dendrimer-FITC for cancer imaging

Cited by 20 publications

References 36 publications

Radiolabeling approaches of nanoparticles with 99mTc

Radiolabeling approaches of nanoparticles with 99mTc

Wireless fluorescence capsule for endoscopy using single photon-based detection

Metal-containing and related polymers for biomedical applications

Contact Info

Product

Resources

About

Radiolabeling approaches of nanoparticles with ^99mTc

Radiolabeling approaches of nanoparticles with ^99mTc