Development of 64Cu-loaded Perfluoropentane Nanodroplet: A Potential Tumor Theragnostic Nano-carrier and Dual-Modality PET-Ultrasound Imaging Agents

Shin, Unchol; Kim, Jungyoung; Lee, Jiwoong; Park, Donghee; Lee, Chang-Moon; Jung, Hyon Chel; Park, Jiae; Lee, Kyochul; Lee, Min Woo; Kim, Suhng Wook; Seo, Jongbum

doi:10.1016/j.ultrasmedbio.2020.05.019

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…To overcome the disadvantages of ultrasound contrast agents, PFP and 64 Cucoloaded phospholipid-shelled nanodroplets were developed as potential contrast agents, contributing to tumor diagnosis by fusing nuclear medicine and ultrasound. 177 Recently, Wang and colleagues structured a caspase-3-activatable [ 18 F]-IR780-1 as the PA/PET bimodal probe through in situ self-assembly and macrocyclization of small molecules to reflex the apoptosis in tumors (Figure 37a). 199 Higher PET and PA signal intensities were found in apoptotic cell suspensions compared to viable or apoptosis-suppressed cells (Figure 37b, c).…”

Section: Multi-modality Imagingmentioning

confidence: 99%

“…As for PET, 64 Cu, and 18 F have been reported for dual-modality imaging with ultrasound. To overcome the disadvantages of ultrasound contrast agents, PFP and 64 Cu-coloaded phospholipid-shelled nanodroplets were developed as potential contrast agents, contributing to tumor diagnosis by fusing nuclear medicine and ultrasound . Recently, Wang and colleagues structured a caspase-3-activatable [ 18 F]-IR780-1 as the PA/PET bimodal probe through in situ self-assembly and macrocyclization of small molecules to reflex the apoptosis in tumors (Figure a) .…”

Section: Ultrasound-based Micro-/nanosystems For Biomedical Imagingmentioning

confidence: 99%

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Huang,

Zheng,

Chang

et al. 2024

Chem. Rev.

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Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed as a physical tool for versatile biomedical applications. Especially, the prosperity of nanotechnology and nanomedicine invigorates the landscape of ultrasound-based medicine. The unprecedented surge in research enthusiasm and dedicated efforts have led to a mass of multifunctional micro-/nanosystems being applied in ultrasound biomedicine, facilitating precise diagnosis, effective treatment, and personalized theranostics. The effective deployment of versatile ultrasound-based micro-/nanosystems in biomedical applications is rooted in a profound understanding of the relationship among composition, structure, property, bioactivity, application, and performance. In this comprehensive review, we elaborate on the general principles regarding the design, synthesis, functionalization, and optimization of ultrasound-based micro-/nanosystems for abundant biomedical applications. In particular, recent advancements in ultrasound-based micro-/nanosystems for diagnostic imaging are meticulously summarized. Furthermore, we systematically elucidate state-of-the-art studies concerning recent progress in ultrasound-based micro-/nanosystems for therapeutic applications targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular diseases, and metabolic diseases. Finally, we conclude and provide an outlook on this research field with an in-depth discussion of the challenges faced and future developments for further extensive clinical translation and application.

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Section: Multi-modality Imagingmentioning

confidence: 99%

Section: Ultrasound-based Micro-/nanosystems For Biomedical Imagingmentioning

confidence: 99%

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Huang,

Zheng,

Chang

et al. 2024

Chem. Rev.

View full text Add to dashboard Cite

show abstract

“…Another phospholipid-shelled nanodroplets encapsulating perfluoropentane (PFP) with copper-64 ( 64 Cu) labeled were evaluated for PET/CT and ultrasound imaging. 81 These nanomaterials contribute to the diagnosis by fusing the science and technology of different imaging modalities. Shi et al designed the mesoporous silica gadolinium-loaded gap-enhanced Raman tags for both preoperative and intraoperative imaging.…”

Section: Nanoparticles Designed For the Imaging Of Gastric Cancermentioning

confidence: 99%