Development of 5-fluorouracil loaded poly(acrylamide-co-methylmethacrylate) novel core-shell microspheres: In vitro release studies

Babu, V. Ramesh; Sairam, M.; Hosamani, Kallappa M.; Aminabhavi, Tejraj M.

doi:10.1016/j.ijpharm.2006.06.020

Cited by 64 publications

(33 citation statements)

References 33 publications

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“…Figure 6 displays the release profiles of poly(VCL-co-AAm) microspheres loaded with different amounts of 5-FU at 37 • C. Notice that initially, during the first hour, release is quite fast in all the formulations. Such observations were also found in our earlier studies on the release of 5-FU from microspheres prepared from poly(acrylamide) and co-polymers of acrylamide with methyl methacrylate [22,23]. The present cumulative release data suggest that those formulations containing the highest amount of drug (i.e., 15 wt%) displayed higher release rates than those containing smaller amounts of 5-FU (i.e., 10 and 5 wt%).…”

Section: Effect Of Cross-linking Agentsupporting

confidence: 89%

“…This mixture was added to the reaction mixture drop-wise using a dropping funnel and the reaction was continued for 8 h at 70 • C to obtain optimum yields of the final product. The reaction mixture was taken out after 8 h and drop-wise added to 1% calcium chloride solution [23]. Particles were then isolated by centrifuging the product at a rotor speed of 12 000 rpm, washed with water and dried under vacuum at 40 • C for 24 h. Eight different batches of formulations were prepared by varying the amounts of monomer, drug and the cross-linking agent.…”

Section: Synthesis Of Poly(n -Vinyl Caprolactam-co-acrylamide) Microsmentioning

confidence: 99%

“…5-Fluorouracil (5-FU) is a well-known anti-cancer drug, being acidic and soluble in water [23], widely used in clinical chemotherapy for treating solid tumors. However, due to its erratic oral bioavailability, intravenous administration is currently in clinical use.…”

Section: Introductionmentioning

confidence: 99%

“…However, due to its erratic oral bioavailability, intravenous administration is currently in clinical use. Some 5-FU formulations have been developed before [22,23] using polyacrylamide and poly(methyl methacrylate). In continuation of this work, we now present a novel process for the development of 5-FU-loaded poly(vinyl caprolactam-co-acrylamide) microspheres to investigate their CR characteristics.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Method to Prepare 5-Fluorouracil, an Anti-cancer Drug, Loaded Microspheres from Poly(N-vinyl caprolactam-co-acrylamide) and Controlled Release Studies

Mundargi¹,

Rangaswamy²,

Aminabhavi

2010

Designed Monomers and Polymers

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Poly(N-vinyl caprolactam-co-acrylamide) co-polymers cross-linked with N,N -methylene bisacrylamide loaded with 5-fluorouracil (5-FU) have been investigated for controlled release of 5-FU, an anticancer drug. Microspheres of poly(N-vinyl caprolactam-co-acrylamide) co-polymers cross-linked with N,N -methylene bisacrylamide have been prepared by free radical emulsion polymerization using varying amounts of acrylamide (AAm), N-vinyl caprolactam (VCL) and N,N -methylene bisacrylamide (NNMBA). Particles were produced in the size range of 16-34 µm and 5-FU was encapsulated into these microspheres. The in situ polymerization and release kinetics of drug-loaded microspheres have been investigated in phosphate buffer solution (pH 7.4) at 25 and 37 • C. Scanning electron microscopy (SEM) was used to study the surface morphology of the microspheres. In vitro release data have been affected by varying the co-polymer composition, amount of cross-linking agent and amount of drug loading in the microspheres. Microspheres with different co-polymer compositions were obtained in yields up to 80-85% with encapsulation efficiencies ranging from 69 to 79%. SEM suggested a spherical nature of particles with somewhat rough surfaces. In vitro drug release data indicated that particle size and release kinetics have been influenced by co-polymer composition, amount of cross-linking agent and amount of 5-FU loaded in the microspheres.

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Section: Effect Of Cross-linking Agentsupporting

confidence: 89%

Section: Synthesis Of Poly(n -Vinyl Caprolactam-co-acrylamide) Microsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Novel Method to Prepare 5-Fluorouracil, an Anti-cancer Drug, Loaded Microspheres from Poly(N-vinyl caprolactam-co-acrylamide) and Controlled Release Studies

Mundargi¹,

Rangaswamy²,

Aminabhavi

2010

Designed Monomers and Polymers

Self Cite

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“…Localized delivery of anticancer drug has been developed as an effective administration method of chemotherapeutic agents formulated into biodegradable polymeric microspheres (Babu et al, 2006), injectable hydrogels (Chung et al, 2009) and polymer implants (Denkba et al, 2000). But these drug delivery systems are only capable of delivering one drug.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice

et al. 2012

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Lamotrigine‐loaded polyacrylate nanoparticles synthesized through emulsion polymerization

Shah

Pal

Rajyaguru

et al. 2007

J of Applied Polymer Sci

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A series of copolymeric nanoparticles of the partially water-soluble monomer ethyl methacrylate and the water-soluble monomer 2-hydroxyl ethyl methacrylate were synthesized from emulsions containing sodium dodecyl sulfate via free-radical polymerization. Lamotrigine, as a model drug, was loaded in nanoparticles during in situ polymerization. A stable and transparent poly(ethyl methacrylate-co-hydroxyl ethyl methacrylate) nanolatex was produced for all compositions and characterized for particle size by dynamic light scattering and transmission electron microscopy. Particles were found to be smaller than 50 nm in size. Structural characterization of copolymers was done by infrared spectrometry, gel permeation chromatography, and NMR spectroscopy. Drug encapsulation efficiency was determined by ultraviolet (UV)-visible spectrometry and was found to be 26-62% for copolymers with different compositions. UV data suggest molecularlevel dispersion of the drug in the nanoparticles. In vitro drug-release studies showed the controlled release of lamotrigine.

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Development of 5-fluorouracil loaded poly(acrylamide-co-methylmethacrylate) novel core-shell microspheres: In vitro release studies

Cited by 64 publications

References 33 publications

A Novel Method to Prepare 5-Fluorouracil, an Anti-cancer Drug, Loaded Microspheres from Poly(N-vinyl caprolactam-co-acrylamide) and Controlled Release Studies

A Novel Method to Prepare 5-Fluorouracil, an Anti-cancer Drug, Loaded Microspheres from Poly(N-vinyl caprolactam-co-acrylamide) and Controlled Release Studies

Biodegradable three-dimension micro-device delivering 5-fluorouracil in tumor bearing mice

Lamotrigine‐loaded polyacrylate nanoparticles synthesized through emulsion polymerization

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