Development of 5-(3-alkenyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine derivatives as selective muscarinic agonists for the treatment of Alzheimer's disease

Convenient One-Pot Synthesis of Multisubstituted Tetrahydropyrimidines via Catalyst-Free Multicomponent Reactions

“…Pyrimidines and their analogues represent an important class of nitrogen heterocycles, which is found in both various biologically active natural compounds and designed medicinal agents . Specifically, tetrahydropyrimidines containing an amino acid unit have attracted much attention due to their interesting and unique properties such as muscarinic agonist activity, protein−nucleic acids interaction, antiviral activity, and inflammatory activity . Structure−activity relationship (SAR) studies of the tetrahydropyrimidine derivatives showed that the substituent groups on the rings are all critical for the activity .…”