Development of 3D-printed vaginal devices containing metronidazole for alternative bacterial vaginosis treatment

Utomo, Emilia; Domínguez-Robles, Juan; Anjani, Qonita Kurnia; Picco, Camila J.; Korelidou, Anna; Magee, Erin; Donnelly, Ryan F.; Larrañeta, Eneko

doi:10.1016/j.ijpx.2022.100142

Cited by 12 publications

(8 citation statements)

References 49 publications

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“…As previously shown in Fig. 2 , CLOP particles were found in the SEM images for grafts containing 10 and 20% CLOP; thus, it can be assumed that the amount of crystalline drug is too small to be detected using DSC [ 59 ]. Accordingly, an XRD analysis was performed to further determine CLOP crystallinity.…”

Section: Resultsmentioning

confidence: 98%

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

Adhami,

Picco,

Detamornrat

et al. 2023

Drug Deliv. and Transl. Res.

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The leading cause of death worldwide and a significant factor in decreased quality of life are the cardiovascular diseases. Endovascular operations like angioplasty, stent placement, or atherectomy are often used in vascular surgery to either dilate a narrowed blood artery or remove a blockage. As an alternative, a vascular transplant may be utilised to replace or bypass a dysfunctional or blocked blood vessel. Despite the advancements in endovascular surgery and its popularisation over the past few decades, vascular bypass grafting remains prevalent and is considered the best option for patients in need of long-term revascularisation treatments. Consequently, the demand for synthetic vascular grafts composed of biocompatible materials persists. To address this need, biodegradable clopidogrel (CLOP)-loaded vascular grafts have been fabricated using the digital light processing (DLP) 3D printing technique. A mixture of polylactic acid-polyurethane acrylate (PLA-PUA), low molecular weight polycaprolactone (L-PCL), and CLOP was used to achieve the required mechanical and biological properties for vascular grafts. The 3D printing technology provides precise detail in terms of shape and size, which lead to the fabrication of customised vascular grafts. The fabricated vascular grafts were fully characterised using different techniques, and finally, the drug release was evaluated. Results suggested that the performed 3D-printed small-diameter vascular grafts containing the highest CLOP cargo (20% w/w) were able to provide a sustained drug release for up to 27 days. Furthermore, all the CLOP-loaded 3D-printed materials resulted in a substantial reduction of the platelet deposition across their surface compared to the blank materials containing no drug. Haemolysis percentage for all the 3D-printed samples was lower than 5%. Moreover, 3D-printed materials were able to provide a supportive environment for cellular attachment, viability, and growth. A substantial increase in cell growth was detected between the blank and drug-loaded grafts. Graphical Abstract

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Section: Resultsmentioning

confidence: 98%

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

Adhami,

Picco,

Detamornrat

et al. 2023

Drug Deliv. and Transl. Res.

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“…The developed medication presents a viable alternative approach to the already established treatment based on the available data. This is attributed to its ability to provide a prolonged discharging MTZ, shortening the course of therapy and eventually improving the patient's outcomes [53].…”

Section: Vaginal Systemsmentioning

confidence: 99%

A recent review of the utilization of 3D printing in the development and manufacturing of pharmaceutical dosage forms

ESER ALENEZI,

KERİMOĞLU,

UĞURLU

2024

jrp

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printing has paved the way in pharmaceutical applications. This innovative methodology presents novel and inventive remedies for patients and the pharmaceutical sector. Moreover, the benefits of this approach encompass the mitigation of adverse effects, customization of formulations for patients with rare medical conditions, and enhancement of therapeutic effectiveness. The objective of our review was to offer a comprehensive survey of the advancements observed in the drug delivery systems that were produced. A thorough inspection has assessed the diverse dosage forms developed using the three-dimensional printing technique (3DP), especially in the last five years. The pharmaceutical industry places significant emphasis on the benefits of developing dosage forms with intricate designs and geometries, incorporating multiple active ingredients, and tailored release profiles due to their versatility and related advantages. Drug delivery systems can be classified into different modalities, tablets, capsules, suppositories, transdermal delivery systems, microneedles, vaginal delivery systems, and nanoscale dosage forms. The utilization of our classification system facilitates researchers' task of evaluating publications and effectively pinpointing further opportunities for research exploration.

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“…Bacterial vaginosis is caused by a change in vaginal microbiota, most often by bacterial overgrowth of the common bacteria Gardnerella vaginalis. The most effective treatment includes oral and topical administration of antibiotics, such as metronidazole (MTZ) [1]. It belongs to the synthetic antibiotics derived from nitroimidazole, originally detected in cultures of Streptomyces [2,3].…”

Section: Introductionmentioning

confidence: 99%

Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the Composition

Bartoníková,

Špaglová,

Papadakos

et al. 2024

Sci. Pharm.

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(1) Background: The study aimed to compare the impact of various natural polymers–sodium alginate, acacia gum, carrageenan, guar gum, xanthan gum, and tragacanth on the formulation and the physical properties of mucoadhesive vaginal tablets containing metronidazole (167 mg/g). (2) Methods: The quality of the tablets prepared by direct compression was evaluated by pharmacopoeia tests (uniformity of mass, resistance to crushing, friability). Mucoadhesion of the tablets was characterized by swelling capacity and mucoadhesive strength, i.e., the force required to detach the tablet from the rabbit mucosa. In vitro drug release was performed by a modified dissolution method in paddle apparatus containing the simulated vaginal fluid (pH 4.5). Scanning electron microscopy observed morphological changes on the swollen tablets’ surface. (3) Results: Pharmacopoeia tests have shown that all prepared tablets met the requirements on quality. The highest mucoadhesive strength was noted in tablets containing guar and xanthan gum. The highest swelling capacity was possessed by tablets containing carrageenan. (4) Conclusions: Summarizing all tests’ results, sodium alginate can be considered the most suitable natural polymer in tablet formulation. The combination of polymers providing higher mucoadhesiveness and at the same time a prolonged release, e.g., xanthan or guar, together with sodium alginate, could also be of interest.

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Development of 3D-printed vaginal devices containing metronidazole for alternative bacterial vaginosis treatment

Cited by 12 publications

References 49 publications

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

A recent review of the utilization of 3D printing in the development and manufacturing of pharmaceutical dosage forms

Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the Composition

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