Development of 3-D detector system for positron CT

Shimizu, Katsuji; Ohmura, T.; Watanabe, M.; Uchida, Hiroshi; Yamashita, T.

doi:10.1109/23.12818

Cited by 52 publications

(18 citation statements)

References 13 publications

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“…Studies reported in the literature about PET designs [8,[10][11][12][13] where the DoI information is obtained reading out both crystal ends [14], refer to conventional PET geometries with shorter scintillator bars (2-3 cm) and a surface finish different (raw) from ours, thus favouring diffuse reflection of scintillation light from the crystal lateral surfaces, rather than specular one.…”

Section: Article In Pressmentioning

confidence: 98%

Optimization of the effective light attenuation length of YAP:Ce and LYSO:Ce crystals for a novel geometrical PET concept

Vilardi

Braem

Chesi

et al. 2006

Nuclear Instruments and Methods in Physics Research Section A:

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Section: Article In Pressmentioning

confidence: 98%

Optimization of the effective light attenuation length of YAP:Ce and LYSO:Ce crystals for a novel geometrical PET concept

Vilardi

Braem

Chesi

et al. 2006

Nuclear Instruments and Methods in Physics Research Section A:

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“…This approach, which was first proposed by Hamamatsu researchers [45], utilized two position-sensitive PMTs (Hamamatsu R2487) coupled to both ends of a 4 × 8 BGO (3.75 × 7 × 100 mm 3 ) crystal array. The DOI resolution was obtained to be approximately 9.5 mm FWHM for each irradiation positions at 10 mm intervals (100 mm length).…”

Section: Continuous Doi Measurement By Dual-ended Readout Detectorsmentioning

confidence: 99%

Positron emission tomography (PET) detectors with depth-of- interaction (DOI) capability

2011

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Because positron emission tomography (PET) provides biochemical information in vivo with the sensitivity at the sub-pico-molar level, pre-clinical research using PET plays an important role in biological and pharmaceutical sciences. However, small animal imaging by PET has been challenging with respect to spatial resolution and sensitivity due to the small volume of the imaging objects. A DOI-encoding technique allows for pre-clinical PET to simultaneously achieve high spatial resolution and high sensitivity. Thus many DOI-encoding methods have been proposed. In this paper we describe why DOI measurements are important, what is required in DOI-encoding designs, and how to extract DOI information in scintillator-based DOI detectors. Recently, there has been a growing interest in DOI measurements for TOF PET detectors to correct time walk as a function of DOI position. Thus, the DOI-encoding method with a high time performance suitable for TOF detectors is now required. The requirements to improve the time resolution in DOI detectors are discussed as well.Keywords Positron emission tomography (PET), Depth of interaction (DOI), Multi-layer detector, Dual-ended readout, Single-ended readout THE IMPORTANCE OF DOI MEASUREMENT Simultaneous improvement in spatial resolution and sensitivityThe PET is an important pre-clinical imaging technique because PET provides biochemical information down to the sub-pico-molar level in vivo [1]. Thus, the development of pre-clinical PET scanners has been actively promoted. The major focus of the development is to obtain a similar quality in small animal images as human images, while the size of the imaging subject decreases and the amount of radiopharmaceutical injected into the small animals is limitedTo obtain a similar level of detail and SNR in mouse images as human images, spatial resolution and sensitivity should be increased. That is why many PET instrument researchers have been attempting for the pre-clinical PET to simultaneously achieve high spatial resolution and high sensitivity. The pre-clinical PET systems therefore have been designed by using very long and narrow crystals with small diameter ring geometry. However, such system structures cause the parallax error to become lager when providing no depth-of-interaction (DOI) information within crystals (general PETs can measure no DOI information), and bring the degradation of the radial resolution in the peripheral field of view (FOV). That is because the reconstruction algorithm, when drawing a line of response (LOR) without DOI information, usually assigns the interaction positions over all depths within a crystal to a single position (i.e. the center position on the front of the interacted crystals).

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“…Studies reported in literature on PET designs [5][6][7][8] where the DoI information is obtained reading out both the crystal ends [9], refer to shorter scintillator bars (2-3 cm) with their lateral surfaces finished differently (raw) from our concept, favouring more the diffuse reflection of scintillation light on the crystal lateral surfaces, rather than the specular reflection.…”

Section: Introductionmentioning

confidence: 99%