Development of 3-Acetylcoumarin derived organosilane as potent antioxidant: Selective and sensitive colorimetric and fluorescent sensor for Al3+ ions

Singh, Gurjaspreet; Suman, .; Diksha, .; Mohit, .; Gupta, Sofia; Thakur, Yamini; Gonzalez-SilveraEspinosa-RuizAngelesEsteban,

doi:10.1016/j.ica.2022.120921

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…AMDET is an open-source repository that is continually refreshed with comprehensive data obtained from the latest literature publications. [44] These calculated values are parallel to the values reported in literature [44][45][46] and suggest that all the synthesized compounds have the potential to act as potential drug molecules. The values derived from ADMET predictors, as delineated in Table 4, affirm the viability of all the compounds as promising candidates for further scrutiny.…”

Section: In-silico Admet Predictionsupporting

confidence: 82%

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Singh,

Thakur,

Priyanka

et al. 2024

ChemistrySelect

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Chromium is known to play an important role in various metabolic pathways; however, its excessive use can result in negative impact on mankind, this necessitates the development of sensors for Cr(III) ion. The current study has incorporated the synthesis of ether derived Schiff base allied silanes 4 a–4 d, which have been characterized using 1H NMR, 13C NMR and mass spectrometry. The spectroscopic technique of UV‐visible has been utilized to study the sensing behaviour of probe 4 a, resulting in a good sensing ability towards Cr(III) ion, yielding a detection limit of 4.2×10−7 M and an association constant value of 2.25×106 M−1. In order to study the stoichiometric binding between probe and metal ion, Job's plot method has been employed which shows 1 : 1 binding ratio. The mechanism of binding has been studied via 1H NMR, UV‐visible, FT‐IR spectroscopy and mass spectrometry. The binding has been further supported by DFT. The real sample analysis has been performed to validate the utility of the synthesized sensor in practical applications. The theoretical tool of molecular docking has been considered to study the protein‐ligand interaction between S. aureus bacterial protein and ligand 4 a, yielding a value of −7.63 kcal/mol for binding energy.

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Section: In-silico Admet Predictionsupporting

confidence: 82%

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Singh,

Thakur,

Priyanka

et al. 2024

ChemistrySelect

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“…[22][23][24] However, an increased level of Al(III) in the brain can result in conditions like Parkinson's disease, osmotic encephalopathy and Alzheimer's disease. [25][26][27] According to WHO standards, the daily consumption of Al(III) ions should be less than 3-10 mg, and the maximum Al(III) concentration in drinking water should not exceed 7.41 mM. 28 On the other hand, 4-nitrophenol (4-NP), a nitroaromatic, is commonly used in the production of dyes, pesticides, paper, petroleum, explosives, hair pigment, drugs and other natural pollutants that endanger public safety and health.…”

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confidence: 99%

Organosilane based magnetic silica nanoparticles for the detection of Al(iii) ions and construction of a molecular logic gate

et al. 2023

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Designing of click-derived 1,2,3-triazoles as potential anti-bacterial agents and sensor towards Al(III) ion in aqueous medium

Singh,

Thakur,

Shilpy

et al. 2023

Inorganic Chemistry Communications

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Development of 3-Acetylcoumarin derived organosilane as potent antioxidant: Selective and sensitive colorimetric and fluorescent sensor for Al3+ ions

Cited by 3 publications

References 27 publications

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Organosilane based magnetic silica nanoparticles for the detection of Al(iii) ions and construction of a molecular logic gate

Designing of click-derived 1,2,3-triazoles as potential anti-bacterial agents and sensor towards Al(III) ion in aqueous medium

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