Development of 111In DOTMP for dosimetry of bone pain palliation agents

Yousefnia, Hassan; Jalilian, Amir Reza; Zolghadri, Samaneh; Mirzaei, Alireza; Bahrami-Samani, Ali; Mirzaii, M.; Ghannadi, M.

doi:10.1007/s10967-014-3911-6

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…As an example, ((1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(methylene))tetraphosphonic acid, DOTP, compound 14 , Fig. 4 ), was assessed to complex indium [ 86 ] or terbium [ 87 ] with the aim to develop bone targeting and dosimetry. It was also employed to complex 89 Y and applied as pH sensitive NMR probe [ 88 ], or as organic precursor of crystalline manganese, nickel [ 89 ] or lanthanide-containing hybrid materials [ 90 ].…”

Section: Reviewmentioning

confidence: 99%

Phosphonic acid: preparation and applications

Sevrain¹,

Berchel²,

Couthon³

et al. 2017

Beilstein J. Org. Chem.

137

103

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The phosphonic acid functional group, which is characterized by a phosphorus atom bonded to three oxygen atoms (two hydroxy groups and one P=O double bond) and one carbon atom, is employed for many applications due to its structural analogy with the phosphate moiety or to its coordination or supramolecular properties. Phosphonic acids were used for their bioactive properties (drug, pro-drug), for bone targeting, for the design of supramolecular or hybrid materials, for the functionalization of surfaces, for analytical purposes, for medical imaging or as phosphoantigen. These applications are covering a large panel of research fields including chemistry, biology and physics thus making the synthesis of phosphonic acids a determinant question for numerous research projects. This review gives, first, an overview of the different fields of application of phosphonic acids that are illustrated with studies mainly selected over the last 20 years. Further, this review reports the different methods that can be used for the synthesis of phosphonic acids from dialkyl or diaryl phosphonate, from dichlorophosphine or dichlorophosphine oxide, from phosphonodiamide, or by oxidation of phosphinic acid. Direct methods that make use of phosphorous acid (H3PO3) and that produce a phosphonic acid functional group simultaneously to the formation of the P–C bond, are also surveyed. Among all these methods, the dealkylation of dialkyl phosphonates under either acidic conditions (HCl) or using the McKenna procedure (a two-step reaction that makes use of bromotrimethylsilane followed by methanolysis) constitute the best methods to prepare phosphonic acids.

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Section: Reviewmentioning

confidence: 99%

Phosphonic acid: preparation and applications

Sevrain¹,

Berchel²,

Couthon³

et al. 2017

Beilstein J. Org. Chem.

137

103

View full text Add to dashboard Cite

show abstract

“…In the H 8 DOTMP ligand (((1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetrakis(methylene))tetraphosphonic acid) the carboxylate oxygen donors of H 4 DOTA are replaced by phosphonate ones. This chelator has been considered for a bone-seeking agent with various radioisotopes ( 111 In, 166 Ho, 153 Sm, 177 Lu, 212 Bi). − In this study both the form with the fully deprotonated (charge 8−) and that with the half-deprotonated (charge 4−) tetraphosphonic acid were probed. The two forms facilitate a comparison of the coordination interactions in strong and moderately alkaline environments.…”

Section: Ligandsmentioning

confidence: 99%

Metal–Ligand Interactions in Scandium Complexes with Radiopharmaceutical Applications

Kovács

2023

Inorg. Chem.

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The radioisotopes of scandium (43Sc, 44Sc, and 47Sc) are potential candidates for use in imaging and therapy both separately and as elementally matched pairs for radiotheranostics. In the present study the bonding interactions of Sc3+ with 18 hepta- to decadentate ligands are compared using density functional theory (DFT) calculations. The bonding analysis is based on the natural bond orbital (NBO) model. The main contributions to the bonding were assessed using natural energy decomposition analysis (NEDA). Most of the ligands have anionic character (charges from 2– to 8−); thus the electrical term determines the major differences in the interaction energies. However, interesting features were found in the covalent contributions manifested by the ligand → Sc3+ charge transfer (CT) interactions. Significant differences could be observed in the energetic contributions of the N and O donors to the total CT.

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“…Bi) [66][67][68][69][70][71]. It has also been probed for 225 Ac and substantial radiolabelling was observed [65].…”

Section: Ligandsmentioning

confidence: 99%

Metal–ligand interactions in complexes of cyclen-based ligands with Bi and Ac

Kovács

Varga

2021

Struct Chem

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The structural and bonding properties of Bi and Ac complexes with cyclen-based chelating ligands have been studied using relativistic DFT calculations in conjunction with TZ2P all-electron basis sets. Besides the parent cyclen ligand, the study has covered its extensions with pyridine-type (Lpy), carboxylate (DOTA, DOTPA), picolinate (MeDO2PA) and phosphonate (DOTMP) pendant arms. The effect of the cyclen ring size has been probed by increasing it from [12]aneN4 to [16]aneN4. Additional extensions in the DOTA complexes included the H2O ligand at the 9th coordination site as well as the p-SCN-Bn substituent (a popular linker to the targeting vector). The study focuses on the complex stability, the nature of bonding and the differences between Ac and Bi in the complexes. The metal–ligand interactions have been analysed by the Extended Transition State method combined with Natural Orbitals of Chemical Valence theory and Quantum Theory of Atoms in Molecules models.

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Development of 111In DOTMP for dosimetry of bone pain palliation agents

Cited by 8 publications

References 8 publications

Phosphonic acid: preparation and applications

Phosphonic acid: preparation and applications

Metal–Ligand Interactions in Scandium Complexes with Radiopharmaceutical Applications

Metal–ligand interactions in complexes of cyclen-based ligands with Bi and Ac

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