Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats

Schenk, Susan; Gittings, David; Johnstone, M; Daniela, Evangeline

doi:10.1007/s00213-003-1407-0

Cited by 130 publications

(165 citation statements)

References 54 publications

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“…This finding is consistent with previous reports from studies with rats (Ratzenboeck et al 2001;Schenk et al 2003), rhesus monkeys (Beardsley et al 1986;Fantegrossi et al 2002;Fantegrossi 2006;Lile et al 2005) and baboons (Lamb and Griffiths 1987), and with the well-established abuse liability of MDMA (Strote et al 2002;Yacoubian 2003). The study by Lile et al (2005) used a PR schedule similar to the one used in the present study, but with a different progression in response requirement and a shorter TO between injections.…”

Section: Discussionsupporting

confidence: 92%

“…Considering that increased 5-HT potency relative to DA appears to reduce reinforcing strength, MDMA might be predicted to be a relatively weaker reinforcer than MA. Research has demonstrated that MDMA, like MA, can function as a positive reinforcer in monkeys (Beardsley et al 1986;Fantegrossi et al 2002;Lamb and Griffiths 1987) and rats (Ratzenboeck et al 2001;Schenk et al 2003), although concerns have recently been raised about the relevance to the human situation of MDMA selfadministration by rats (De La Garza et al 2006). Although these studies did not provide estimates of relative reinforcing strength, MDMA sometimes maintained less responding than other drugs.…”

Section: Introductionmentioning

confidence: 99%

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Estimating the relative reinforcing strength of (±)-3,4-methylenedioxymethamphetamine (MDMA) and its isomers in rhesus monkeys: comparison to (+)-methamphetamine

Wang

Woolverton

2006

Psychopharmacology

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Rationale (±)3,4-Methylenedioxymethamphetamine (MDMA) is an analog of methamphetamine (MA) and a drug of abuse. MA, MDMA, and its isomers release monoamine neurotransmitters with varying selectivities and would, therefore, be predicted to vary in their relative strength as reinforcers. Objectives This study compared self-administration of MA, MDMA, and its isomers using a progressive-ratio schedule in rhesus monkeys. Conclusions MDMA and (+)-MDMA were consistent positive reinforcers, but weaker than MA, whereas (−)-MDMA was, at best, a weak reinforcer in some monkeys. The reinforcing strength of MDMA appears to derive primarily from (+)-MDMA. Because MDMA and its isomers have been shown to have relatively higher serotonin to dopamine releasing potency, these data support the hypothesis that increasing 5-HT releasing potency relative to DA is associated with weaker reinforcing effects.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Estimating the relative reinforcing strength of (±)-3,4-methylenedioxymethamphetamine (MDMA) and its isomers in rhesus monkeys: comparison to (+)-methamphetamine

Wang

Woolverton

2006

Psychopharmacology

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“…The blocking effect of DAT caused by MDMA contributes to its addictive properties, its self-administration and human misuse, and its robust locomotor activation (Bankson and Cunningham 2001;Baumann et al 2005;Ratzenboeck et al 2001;Schenk et al 2003). It may also account for the drug's antiparkinsonian and antidyskinetic effects in animal models of extrapyramidal disorders (Iravani et al 2003;Schmidt et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Electrophysiologic Changes in Ventral Midbrain Dopaminergic Neurons Resulting from (+/−) -3,4-Methylenedioxymethamphetamine (MDMA—“Ecstasy”)

Federici

Sebastianelli

Natoli

et al. 2007

Biological Psychiatry

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“…Primates (Beardsley et al, 1986;Fantegrossi et al, 2002Fantegrossi et al, , 2004Lamb and Griffiths, 1987;Lile et al, 2005), rats (Braida and Sala, 2002;Braida et al, 2005;Cornish et al, 2003;Daniela et al, 2004;Schenk et al, 2003), and mice (Trigo et al, 2006) learn to perform an operant response to obtain an infusion of MDMA, which suggests the addictive potential of this drug.…”

Section: Introductionmentioning

confidence: 99%

Rewarding Effects and Reinstatement of MDMA-Induced CPP in Adolescent Mice

Daza-Losada

Couto

Manzanedo

et al. 2007

Neuropsychopharmacol

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Although the rewarding effects of 3,4-methylenedioxy-metamphetamine (MDMA) have been demonstrated in self-administration and conditioned place preference (CPP) procedures, its addictive potential (ie, the vulnerability to relapse, measured by its ability to induce reinstatement of an extinguished response), remains poorly understood. In this study, the effects of MDMA (5, 10, and 20 mg/kg) on the acquisition, extinction and reinstatement of CPP were evaluated in mice, using two different protocols during acquisition of CPP. In the first experiment, animals were trained using a two-session/day schedule (MDMA and saline for 4 consecutive days), whereas in the second experiment, they were trained using an alternating day schedule (MDMA and saline each 48 h). After extinction, the ability of drug priming to reinstate CPP was evaluated. In Experiment 1, MDMA did not significantly increase the time spent in the drug-paired compartment during the post-conditioning (Post-C) test, although the preference was evident a week afterwards, lasting between 2 and 21 weeks. No reinstatement was observed after MDMA priming. In Experiment 2, all doses produced CPP in Post-C, which lasted between 1 and 4 weeks. MDMA induces reinstatement at doses up to 4 times lower than those used in conditioning. The analyses of brain monoamines revealed that the daily schedule of treatment induces a non-dose-dependent decrease in dopamine and serotonin (5-HT) in the striatum, whereas the alternating schedule produces a dose-dependent decrease of 5-HT in the cortex. These results demonstrate that MDMA produces long-lasting rewarding effects and reinstatement after extinction, suggesting the susceptibility of this drug to induce addiction.

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Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats

Cited by 130 publications

References 54 publications

Estimating the relative reinforcing strength of (±)-3,4-methylenedioxymethamphetamine (MDMA) and its isomers in rhesus monkeys: comparison to (+)-methamphetamine

Estimating the relative reinforcing strength of (±)-3,4-methylenedioxymethamphetamine (MDMA) and its isomers in rhesus monkeys: comparison to (+)-methamphetamine

Electrophysiologic Changes in Ventral Midbrain Dopaminergic Neurons Resulting from (+/−) -3,4-Methylenedioxymethamphetamine (MDMA—“Ecstasy”)

Rewarding Effects and Reinstatement of MDMA-Induced CPP in Adolescent Mice

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