Development, In Vitro and In Vivo Evaluation of pH Responsiveβ-CD-Comethacrylic Acid-Crosslinked Polymeric Microparticulate System for Solubility Enhancement of Rosuvastatin Calcium

Development andIn-VitroEvaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

“…is phenomenon was seen because of the fact that, an increase in proportion of monomer or cross linking agent resulted into more entanglement of polymer and monomer that led to higher degree of cross linking with less proportion of unreacted contents. ese ndings of our study also shown an agreement with a study performed by Sarfraz et al [18] where they prepared hydrogel micro particles of β-cyclodextrin and methacrylic acid and reported an increase in gel fraction with increasing the proportion of monomer or cross linking agent.…”

“…As the values of angle of repose ranged from 24.30 to 28.9 , (below 30) thus presented the good ow properties by all the prepared formulations. Similar results were reported in studies performed by Sarfraz [18] and Elliot et al [37]. us polymeric network remain in condensed form and less water is penetrated that lead to less swelling of nanogels.…”

“…Similar drug release was reported in studies performed by Peppas et al [22] where they reported the gastro-protective delivery of insulin by using PMAAg-EG nanogels carrier system. In another study performed by Sarfraz et al [18], similar pH dependant release of rosuvastatin calcium was reported from β-cyclodextrin based hydrogel polymeric network system gra ed with methacrylic acid.…”

“…For formulations that are in powder form or particulate systems, determination of rheological parameters is very important in product development process. Materials with poor ow properties are not good candidates for use in solid dosage form thus may lead to improper mixing and loading of drugs as reported by Sarfraz et al [18]. All the results for rheological parameters were found within pharmacopeial limits ( Table 3).…”

“…Nanogels are nano-scale hydrogels particulate systems (hydrogel nanoparticles) that possess the characteristics of hydrogels as well as of nanoparticles at the same time [15,16]. Furthermore, these systems are also a preferred tool for reducing the particle size of the drug [17,18]. is novel drug delivery approach provided the enhancement in bioavailability of drugs as well as reduction in drug related side e ects [14,19,20].…”