Development, Evaluation and in vitro Release Kinetics Study of Immediate Release Tablets of Quercetin Isolated from Bauhinia acuminata Leaves Extract

Abstract

Objective: To isolate quercetin, a flavonoid, from leaves extract of Bauhinia acuminata and to formulate and evaluate immediate release tablets of this quercetin employing direct compression method. Methods: Quercetin was isolated by column chromatography and characterized by FTIR, 1 H and 13 C NMR. Next different formulation blends were prepared using the isolated quercetin with microcrystalline cellulose, magnesium stearate and sodium starch glycolate. Pre-compression studies were performed and tablets were prepared by direct compression method. Tablets were evaluated for various post formulation parameters including disintegration and in vitro dissolution. Release kinetics and release mechanism were also studied from different kinetics plots. Finding : The pre-compression parameters were within the range of hardness (3.37 ± 0.058 to 3.78 ± 0.058 kg/cm 2 ), weight variation (251.25 ± 5.38 to 251.45 ± 5.66 mg), friability (<1%), Drug content (98.17 ± 0.86 to 98.20 ± 0.99 %), disintegration (187.17 ± 2.48 to 126.5 ± 2.26 sec) and in vitro dissolution study (85.33 ± 0.95 % and 86.47 ± 0.70 %) within 30 minutes and 96.84 % and 98.19 % ) within 1 hr respectively for F2 and F3. Novelty: Only few scientific reports are present for Bauhinia acuminata and majority of them are related to pharmacological properties of the extract from the plant only.Here in this study quercetin was isolated for the very first time from Bauhinia acuminata to the best of our knowledge and not only this, the isolated quercetin was formulated to immediate release tablet which is again being reported from this plant for the first time.