Development, commissioning, and evaluation of a new intensity modulated minibeam proton therapy system

Farr, J; Moskvin, V.; Lukose, Renin; Tuomanen, S; Tsiamas, P; Yao, Weiguang

doi:10.1002/mp.13093

Cited by 23 publications

(28 citation statements)

References 29 publications

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“…For this, a model of the PBS nozzle at ICPO as well as a new, optimised nozzle design were created and investigated with respect to their focussing limits. While other groups have recently explored the use of narrow proton beams (diameter ≥3 mm) to improve conventional PBS treatment 11 and proton beam radiosurgery 12 , this work is the first one to evaluate magnetically focussed proton minibeams for pMBRT at a clinical centre.…”

Section: The Current Implementation Of Pmbrt With Mechanical Collimatmentioning

confidence: 99%

Advancing proton minibeam radiation therapy: magnetically focussed proton minibeams at a clinical centre

Schneider

Marzi

Patriarca

et al. 2020

Sci Rep

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Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that has proven to significantly increase dose tolerances and sparing of normal tissue. It uses very narrow proton beams (diameter ≤1 mm), roughly one order of magnitude smaller than state-of-the-art pencil beams. The current implementation of pMBRT with mechanical collimators is suboptimal as it is inflexible, decreases efficiency and produces additional secondary neutrons. As a potential solution, we explore in this article minibeam generation through magnetic focussing and investigate possibilities for the integration of such a technique at existing clinical centres. For this, a model of the pencil beam scanning (PBS) nozzle and beam at the Orsay Proton Therapy Centre was established and Monte Carlo simulations were performed to determine its focussing capabilities. Moreover, various modifications of the nozzle geometry were considered. It was found that the PBS nozzle in its current state is not suitable for magnetic minibeam generation. Instead, a new, optimised nozzle design has been proposed and conditions necessary for minibeam generation were benchmarked. In addition, dose simulations in a water phantom were performed which showed improved dose distributions compared to those obtained with mechanical collimators.

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Section: The Current Implementation Of Pmbrt With Mechanical Collimatmentioning

confidence: 99%

Advancing proton minibeam radiation therapy: magnetically focussed proton minibeams at a clinical centre

Schneider

Marzi

Patriarca

et al. 2020

Sci Rep

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show abstract

“…A recent report of a scanned proton minibeam delivery development stated that a commercial proton therapy system was specially modified to produce scanned minibeams without collimation. 77 The resulting spot sigma was reported to be 1.4 mm at 221 MeV at the isocenter and below 1 mm at proximal distances. Comparative treatment planning results between regular IMPT and minibeam IMPT indicated target conformity improvement for the representative small and large intracranial targets considered ( Fig.…”

Section: A2 Small Scanned Proton Beamsmentioning

confidence: 99%

Section: New Horizons: Beam Delivery Systemsmentioning

confidence: 99%

“…Planar dose difference comparisons between IMPT and IM m PT for the small (above) and large (below) targets …”

Section: New Horizons: Beam Delivery Systemsmentioning

confidence: 99%

“…Planar dose difference comparisons between IMPT and IMmPT for the small (above) and large (below) targets. 77 developed inhomogeneously irradiated ears 3-4 weeks after irradiation." The study suggests further potential for clinical benefit from microbeam techniques.…”

Section: A2 Small Scanned Proton Beamsmentioning

confidence: 99%

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New horizons in particle therapy systems

Farr¹,

Flanz

Gerbershagen

et al. 2018

Medical Physics

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Particle therapy is rapidly expanding and claiming its position as the treatment modality of choice in teletherapy. However, the rate of expansion continues to be restricted by the size and cost of the associated particle therapy systems and their operation. Additional technical limitations such as dose delivery rate, treatment process efficiency, and achievement of superior dose conformity potentially hinder the complete fulfillment of the promise of particle therapy. These topics are explored in this review considering the current state of particle therapy systems and what improvements are required to overcome the current challenges. Beam production systems (accelerators), beam transport systems including gantries and beam delivery systems are addressed explicitly in these regards.

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Automation of Monte Carlo‐based treatment plan verification for proton therapy

Kaluarachchi

Moskvin

Pirlepesov

et al. 2020

J Applied Clin Med Phys

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Independent calculations of proton therapy plans are an important quality control procedure in treatment planning. When using custom Monte Carlo (MC) models of the beamline, deploying the calculations can be laborious, time consuming, and require in-depth knowledge of the computational environment. We developed an automated framework to remove these barriers and integrate our MC model into the clinical workflow. Materials and Methods: The Eclipse Scripting Application Programming Interface was used to initiate the automation process. A series of MATLAB scripts were then used for preprocessing of input data and postprocessing of results. Additional scripts were used to monitor the calculation process and appropriately deploy calculations to an institutional high-performance computing facility. The automated framework and beamline models were validated against 160 patient specific QA measurements from an ionization chamber array and using a ±3%/3 mm gamma criteria. Results: The automation reduced the human-hours required to initiate and run a calculation to 1-2 min without leaving the treatment planning system environment. Validation comparisons had an average passing rate of 99.4% and were performed at depths ranging from 1 to 15 cm. Conclusion: An automated framework for running MC calculations was developed which enables the calculation of dose and linear energy transfer within a clinically relevant workflow and timeline. The models and framework were validated against patient specific QA measurements and exhibited excellent agreement. Before this implementation, execution was prohibitively complex for an untrained individual and its use restricted to a research environment.

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Development, commissioning, and evaluation of a new intensity modulated minibeam proton therapy system

Abstract: We developed, implemented, and tested a new IMMPT system. The initial results look promising in cases where treatments can benefit from additional dose sparing to neighboring sensitive structures.

Cited by 23 publications

References 29 publications

Advancing proton minibeam radiation therapy: magnetically focussed proton minibeams at a clinical centre

Advancing proton minibeam radiation therapy: magnetically focussed proton minibeams at a clinical centre

New horizons in particle therapy systems

Automation of Monte Carlo‐based treatment plan verification for proton therapy

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